ZFIN ID: ZDB-GENE-030131-8290
Gene Name: SRY-box transcription factor 4a
Gene Symbol: sox4a    Nomenclature History

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Previous Names: sox4, wu:fb82f08 (1), wu:fq41g10 (1), zgc:65850, zgc:77392 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in closure of optic fissure and negative regulation of smoothened signaling pathway. Predicted to localize to nucleus and transcription regulator complex. Is expressed in several structures, including anterior neural rod; digestive system; nervous system; neural tube; and periderm. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome and urinary bladder cancer. Orthologous to human SOX4 (SRY-box transcription factor 4).
Genome Resources: Alliance (1),  Gene:336346 (1), 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-sox4a
1
CRISPR2-sox4a
1
MO1-sox4a N/A 1
MO2-sox4a N/A 1
MO3-sox4a N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH sox4a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Coffin-Siris syndrome 10 618506
DISEASE ASSOCIATED WITH sox4a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process closure of optic fissure (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA sox4a-201 (1)    Ensembl 3261
sox4a-203 (1)    Ensembl 597
Browsers: NCBI
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM sox4a No data available
MARKER RELATIONSHIPS
sox4a Contained in: [BAC] DKEY-150K17 (1) (order this)
sox4a Encodes: [EST] fb82f08, fq41g10 (order this)
[cDNA] MGC:65850 (1), MGC:77392 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_213122 (1) 3350 nt
Genomic GenBank:BX957317 (1) 222684 nt Blast at MegaBLAST
Polypeptide UniProtKB:Q6P0Z4 (1) 363 aa
Sequence Information (all 22)
ORTHOLOGY for sox4a ( Chr: 19 )
CITATIONS (38)