FIGURE

Fig. S4

ID

ZDB-FIG-070620-29

Publication

Hinits et al., 2007 - Mef2s are required for thick filament formation in nascent muscle fibres

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Fig. S4

Mef2 knockdown reduces myhz1 but not tnnc mRNA in fast muscle. In situ mRNA hybridisation for myhz1 (A,B) and tnnc (C) (lateral view, anterior to left, dorsal to top). (A) Expression of myhz1 at 24 hpf in wild-type embryos injected with the indicated MOs. (B) myhz1 mRNA in wild type (top row) or embryos from a hoo heterozygote cross (bottom row) injected with mef2d MO. In wild type, mef2d MO had no effect, whereas <25% of the hoo lay appeared wild type, <50% mildly affected and <25% severely affected. (C) No change in level of tnnc in 24-hpf embryos injected with the indicated MO combinations.

Expression Data

Genes:	myhz1.1 tnnc2.2
Fish:	WT WT + MO1-mef2ca WT + MO1-mef2d mef2ca^tn213/tn213 + MO1-mef2d WT + MO1-mef2ca + MO1-mef2d WT + MO2-mef2ca,mef2d WT + MO3-mef2d,mef2ca
Knockdown Reagents:	MO1-mef2ca MO1-mef2d MO2-mef2ca,mef2d MO3-mef2d,mef2ca
Anatomical Term:	fast muscle cell
Stage Range:	20-25 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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