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Gene

myhz1.1

ID
ZDB-GENE-000322-5
Name
myosin, heavy polypeptide 1.1, skeletal muscle
Symbol
myhz1.1 Nomenclature History
Previous Names
  • cb20 (1)
  • fmyhc1.1 (1)
  • myhz1
  • myo2hc1 (1)
  • etID37302.5 (1)
  • fast MyHC (1)
  • fb37e12
  • sb:cb20 (1)
  • si:ch211-158m24.7
  • wu:fb26a08 (1)
  • wu:fb26f12 (1)
  • wu:fb37e12 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable ATP binding activity; actin filament binding activity; and cytoskeletal motor activity. Acts upstream of or within somite specification. Predicted to be part of myosin complex. Is expressed in several structures, including adaxial cell; brain; eye; musculature system; and somite. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; disease of cellular proliferation; and distal arthrogryposis (multiple). Orthologous to several human genes including MYH1 (myosin heavy chain 1) and MYH8 (myosin heavy chain 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
39 figures from 16 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myhz1.1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
proximal myopathy and ophthalmoplegia Alliance Proximal myopathy and ophthalmoplegia 605637
Associated With myhz1.1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR002928 Myosin tail
Domain IPR004009 Myosin, N-terminal, SH3-like
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin head, motor domain Myosin IQ motif-containing domain superfamily Myosin, N-terminal, SH3-like Myosin S1 fragment, N-terminal Myosin tail P-loop containing nucleoside triphosphate hydrolase
UniProtKB:B3DJM6 1937
UniProtKB:A9JT78 941
UniProtKB:E7FAD0 1631
UniProtKB:B8A568 1937
UniProtKB:Q7T1B7 356
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations