FIGURE

Fig. 1

ID

ZDB-FIG-060403-1

Publication

Hogan et al., 2006 - Specification of the Primitive Myeloid Precursor Pool Requires Signaling through Alk8 in Zebrafish

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Fig. 1

Alk8 Is Specifically Required for Myelopoiesis in the Anterior Lateral Plate Mesoderm

(A–D) Gene expression marking cells of the anterior myeloid precursor pool was vastly reduced in lost-a-fin/alk8 (laf) mutant embryos. Expression of pu.1 (A) (n = 16), runx1 (B) (n = 13), c-myb (C) (n = 9), and ikaros (D) (n = 11) is shown.

(E–I) scl expression, endothelial precursor, and myocardial precursor cell types derived from the ALPM develop normally in laf mutant embryos. Expression of scl (E, F) (n = 40 at 10 s and n = 46 at 14 s), gata1 (G) (n = 41), fli1 (H) (n = 9), and nkx2.5 (I) (n = 15) is shown.

All images are dorsal views of the anterior of flat-mounted embryos, with the somitic age shown in the bottom right corner of each panel. The genotype was determined by examining the patterning phenotype of the embryos.

Expression Data

Genes:	fli1 gata1a ikzf1 myb nkx2.5 runx1 spi1b tal1
Fish:	WT acvr1l^gl2/gl2
Anatomical Terms:	anterior lateral plate mesoderm heart primordium ventral mesoderm
Stage Range:	10-13 somites to 14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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