Gene
ikzf1
- ID
- ZDB-GENE-980526-304
- Name
- IKAROS family zinc finger 1 (Ikaros)
- Symbol
- ikzf1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within B cell differentiation and T cell differentiation in thymus. Is expressed in several structures, including hematopoietic cell; hematopoietic system; immune system; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; colorectal cancer; and common variable immunodeficiency 13. Orthologous to human IKZF1 (IKAROS family zinc finger 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 84 figures from 62 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu522 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| common variable immunodeficiency 13 | Alliance | Immunodeficiency, common variable, 13 | 616873 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|
|
UniProtKB:A0A8M2B3C7
|
641 | ||
|
UniProtKB:A0A8M2B3I1
|
496 | ||
|
UniProtKB:O93581
|
537 | ||
|
UniProtKB:A0A8M3AZ03
|
599 | ||
|
UniProtKB:A0A8M2B2R4
|
588 | ||
|
UniProtKB:A0A8M2B2X4
|
538 | ||
|
UniProtKB:A0A8M2B2N6
|
630 |
Interactions and Pathways
No data available
Plasmids