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ZIRC
ZFIN ID: ZDB-GENE-980526-304
Gene Name: IKAROS family zinc finger 1 (Ikaros)
Gene Symbol: ikzf1    Nomenclature History

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Previous Names: ikaros (1), znfn1a1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and transcription regulatory region DNA binding activity. Involved in B cell differentiation and T cell differentiation in thymus. Predicted to localize to the nucleoplasm. Human ortholog(s) of this gene implicated in common variable immunodeficiency and precursor B lymphoblastic lymphoma/leukemia. Is expressed in several structures, including hematopoietic cell; hematopoietic system; immune system; mesoderm; and nervous system. Orthologous to human IKZF1 (IKAROS family zinc finger 1).
Genome Resources: Alliance (1),  Gene:30177 (1),  Ensembl(GRCz11):ENSDARG00000013539 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11269 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22255 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22256 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31915 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t24980 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • t25880 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ikzf1 N/A 1
    MO2-ikzf1 N/A 1
    TALEN1-ikzf1
    1
    DISEASE ASSOCIATED WITH ikzf1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Immunodeficiency, common variable, 13 616873
    DISEASE ASSOCIATED WITH ikzf1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process B cell differentiation (more)
    Cellular Component nucleoplasm (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR013087 (1)
  • InterPro:IPR036236 (1)
  • PROSITE:PS00028 (1)
  • PROSITE:PS50157 (1)
  • Pfam:PF00096 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ikzf1-201 (1)    Ensembl 2301
    ikzf1-202 (1)    Ensembl 1219
    ikzf1-203 (1)    Ensembl 1513
    ikzf1-204 (1)    Ensembl 1639
    ikzf1-205 (1)    Ensembl 1915
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS
    Addgene:Ikaros
    CONSTRUCTS WITH SEQUENCES FROM ikzf1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(ikzf1:EGFP) ikzf1 EGFP Danio rerio 1 17
    TgBAC(ikzf1:tdEos) ikzf1 EostdEos Danio rerio 1 3
    MARKER RELATIONSHIPS
    ikzf1 Contained in: [BAC] CH211-57F7 (1) (order this)
    ikzf1 Encodes: [EST] eu522 (1)
    [cDNA] MGC:193861 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130986 (1) 2309 bp
    Genomic GenBank:BX890571 (1) 167315 bp
    Select Tool
    Polypeptide UniProtKB:B8A603 (1) 537 aa
    Sequence Clusters UniGene:8122 (1)
    Sequence Information (all 45)
    ORTHOLOGY for ikzf1 ( Chr: 13 )
    CITATIONS (117)