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ZIRC
ZFIN ID: ZDB-GENE-980526-321
Gene Name: NK2 homeobox 5
Gene Symbol: nkx2.5
Sequence Ontology ID : SO:0001217

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Previous Names: nk2.5, nkx2-5, sb:eu581, tinman homeobox homolog, zgc:111912

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(Including Attributions)
Location: Chr: 14 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in several processes, including circulatory system  ...
GENE EXPRESSION
All Expression Data: 211 figures from 149 publications
Directly Submitted Expression Data: 6 figures (16 images) from Thisse et al., 2004 [MGC:111912]
  6 figures (12 images) from Thisse et al., 2005 [eu581]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
vu179 Point Mutation Unknown Premature Stop ENU
Targeting reagents:
DISEASE ASSOCIATED WITH nkx2.5 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
atrial heart septal defect 7 Atrial septal defect 7, with or without AV conduction defects 108900
congenital nongoitrous hypothyroidism 5 Hypothyroidism, congenital nongoitrous, 5 225250
double outlet right ventricle Conotruncal heart malformations, variable 217095
hypoplastic left heart syndrome Hypoplastic left heart syndrome 2 614435
tetralogy of Fallot Tetralogy of Fallot 187500
ventricular septal defect Ventricular septal defect 3 614432
DISEASE ASSOCIATED WITH nkx2.5 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process artery development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 24)
TRANSCRIPTS
Type Name Length (bp) Analysis
mRNA nkx2.5-201 (1) 1657
GENE PRODUCT DESCRIPTION
INTERACTIONS AND PATHWAYS
ANTIBODIES
PLASMIDS No data available
MARKER RELATIONSHIPS
nkx2.5 Contained in: [BAC] CH73-269A20 (1) (order this)
nkx2.5 Encodes: [EST] eu581 (1)
[cDNA] MGC:111912 (1) (order this), MGC:191511 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131421 (1) 1658 bp
Genomic GenBank:CU019640 (1) 45505 bp
Select Tool
Polypeptide UniProtKB:A0A2R8RJR5 (1) 314 aa
Sequence Clusters UniGene:271 (1)
Sequence Information (all 23)
ORTHOLOGY for nkx2.5 ( Chr: 14 )
CITATIONS (298)