Gene
gata1a
- ID
- ZDB-GENE-980526-268
- Name
- GATA binding protein 1a
- Symbol
- gata1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of primitive erythrocyte differentiation. Predicted to be active in nucleus. Is expressed in several structures, including ball; cardiovascular system; hematopoietic cell; hematopoietic system; and mesoderm. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); bone marrow cancer (multiple); colon adenocarcinoma; depressive disorder; and myeloid leukemia associated with Down Syndrome. Orthologous to human GATA1 (GATA binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 497 figures from 349 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu551 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 27 figures from 20 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cig8Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| hg2 | Allele with one point mutation | Unknown | Missense | ENU | |
| hg3 | Allele with one point mutation | Unknown | Missense | ENU | |
| ihb509 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| ihb532 | Allele with one delins | Unknown | Unknown | CRISPR | |
| m651 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa1048 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18633 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 8 of 8
Show
1 - 10 of 10
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonspherocytic hemolytic anemia 9 | Alliance | Anemia, congenital, nonspherocytic hemolytic, 9 | 301083 |
| thrombocytopenia | Alliance | Thrombocytopenia, X-linked, with or without dyserythropoietic anemia | 300367 |
| transient myeloproliferative syndrome | Alliance | Leukemia, megakaryoblastic, with or without Down syndrome, somatic | 159595 |
| X-linked dyserythropoietic anemia | Alliance | Anemia, X-linked, with/without neutropenia and/or platelet abnormalities | 300835 |
| X-linked thrombocytopenia with beta-thalassemia | Alliance | Thrombocytopenia with beta-thalassemia, X-linked | 314050 |
1 - 5 of 5
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Transcription factor GATA | Transcription factor, GATA-2/3 | Zinc finger, GATA-type | Zinc finger, NHR/GATA-type |
|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QT05 | InterPro | 418 | ||||
| UniProtKB:Q90410 | InterPro | 418 | ||||
| UniProtKB:A0AB32TWQ1 | InterPro | 400 |
1 - 3 of 3
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gata1a-201
(1)
|
Ensembl | 1,657 nt | ||
| ncRNA |
gata1a-002
(1)
|
Ensembl | 730 nt |
1 - 2 of 2
Interactions and Pathways
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-8.1gata1:gata1-EGFP) |
|
| 1 | (12) | |
| Tg(gata1a:DsRed) |
|
| 1 | (453) | |
| Tg(gata1a:GFP) |
|
| 2 | (63) | |
| Tg2(gata1a:DsRed) |
|
| 1 | (2) | |
| Tg2(gata1a:EGFP) |
|
| 1 | Yang et al., 2019 | |
| Tg2(gata1a:GFP) |
|
| 1 | (3) | |
| Tg3(gata1a:DsRed) |
|
| 1 | (2) | |
| Tg(-8.1gata1a:mRFP) |
|
| 1 | (14) | |
| Tg(gata1a:deltaBR-GFP) |
|
| 1 | (5) | |
| Tg(gata1a:EGFP) |
|
| 5 | (16) |
1 - 10 of 17
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-97E7 | ZFIN Curated Data | |
| Encodes | EST | eu551 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:153883 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191963 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131234 (1) | 2623 nt | ||
| Genomic | GenBank:AL844847 (1) | 235174 nt | ||
| Polypeptide | UniProtKB:A0A2R8QT05 (1) | 418 aa |
- Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Liu, X., Li, S., Su, B., Dong, Y., Huang, S. (2025) Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell Death & Disease. 16:8484
- Ter Horst, S., Siekierska, A., De Meulemeester, A.S., Cuvry, A., Cools, L., Neyts, J., de Witte, P., Rocha-Pereira, J. (2025) The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent. Viruses. 17:
- Gimenez, G., Kalev-Zylinska, M.L., Morison, I., Bohlander, S.K., Horsfield, J.A., Antony, J. (2024) Cohesin rad21 mutation dysregulates erythropoiesis and granulopoiesis output within the whole kidney marrow of adult zebrafish. American journal of physiology. Cell physiology. 328(1):C9-C19
- Han, X., He, W., Liang, D., Liu, X., Zhou, J., de Thé, H., Zhu, J., Yuan, H. (2024) Creg1 Regulates Erythroid Development via TGF-β/Smad2-Klf1 Axis in Zebrafish. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 11(33):e2402804
- Han, Y., Sun, K., Yu, S., Qin, Y., Zhang, Z., Luo, J., Hu, H., Dai, L., Cui, M., Jiang, C., Liu, F., Huang, Y., Gao, P., Chen, X., Xin, T., Ren, X., Wu, X., Song, J., Wang, Q., Tang, Z., Chen, J., Zhang, H., Zhang, X., Liu, M., Luo, D. (2024) A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO journal. 43(10):1990-2014
- Ketharnathan, S., Pokharel, S., Prykhozhij, S.V., Cordeiro-Santanach, A., Ban, K., Dogan, S., Hoang, H.D., Liebman, M.F., Leung, E., Alain, T., Alecu, I., Bennett, S.A.L., Čuperlović-Culf, M., Dror, Y., Berman, J.N. (2024) Loss of Dnajc21 leads to cytopenia and altered nucleotide metabolism in zebrafish. Leukemia. 38(10):2115-2126
- Lawir, D.F., Soza-Ried, C., Iwanami, N., Siamishi, I., Bylund, G.O., O Meara, C., Sikora, K., Kanzler, B., Johansson, E., Schorpp, M., Cauchy, P., Boehm, T. (2024) Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Communications biology. 7:3131
- Ling, Y., Wu, J., Liu, Y., Meng, P., Sun, Y., Zhao, D., Lin, Q. (2024) Establishment of a Diamond-Blackfan anemia like model in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(10):906-921
- Lints, R., Walker, C.A., Delfi, O., Prouse, M., De Silva, M.P., Bohlander, S.K., Wood, A.C. (2024) Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic NRAS in zebrafish myeloid leukaemia. Biology Open. 13(9):
- Lv, Y., Li, J., Yu, S., Zhang, Y., Hu, H., Sun, K., Jia, D., Han, Y., Tu, J., Huang, Y., Liu, X., Zhang, X., Gao, P., Chen, X., Shaw Williams, M.T., Tang, Z., Shu, X., Liu, M., Ren, X. (2024) The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis. The Journal of biological chemistry. 300(3):105772
1 - 10 of 677
Show