ZFIN ID: ZDB-GENE-980526-268
Gene Name: GATA binding protein 1a
Gene Symbol: gata1a    Nomenclature History

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Previous Names: gata1, gta1 (1), zg1, etID309774.11 (1), sb:eu551, vlad tepes, vlt

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including hemopoiesis; regulation of gene expression; and regulation of myeloid cell differentiation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in Down syndrome; beta thalassemia; myelodysplastic syndrome; myelofibrosis; and transient myeloproliferative syndrome. Is expressed in several structures, including ball; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Orthologous to human GATA1 (GATA binding protein 1).
Genome Resources: Alliance (1),  Gene:30481 (1),  Ensembl(GRCz11):ENSDARG00000013477 (1)
GENE EXPRESSION
All Expression Data: 412 figures from 292 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2005 [eu551]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cig8Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
hg2 Point Mutation Unknown Missense ENU
hg3 Point Mutation Unknown Missense ENU
m651 Point Mutation Unknown Premature Stop ENU
  • China Zebrafish Resource Center (CZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1048 Point Mutation Unknown Splice Site ENU
    sa18633 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gata1a
    1
    CRISPR2-gata1a
    2
    CRISPR3-gata1a 1
    MO1-gata1a N/A 37
    MO2-gata1a N/A 8
    MO3-gata1a N/A 1
    MO4-gata1a N/A 1
    DISEASE ASSOCIATED WITH gata1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Down syndrome Alliance Leukemia, megakaryoblastic, with or without Down syndrome, somatic 190685
    thrombocytopenia Alliance Thrombocytopenia, X-linked, with or without dyserythropoietic anemia 300367
    X-linked thrombocytopenia with beta-thalassemia Alliance Thrombocytopenia with beta-thalassemia, X-linked 314050
    Anemia, X-linked, with/without neutropenia and/or platelet abnormalities 300835
    DISEASE ASSOCIATED WITH gata1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process myeloid cell differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 26)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000679 Zinc finger, GATA-type
    Family IPR016374 Transcription factor, GATA-2/3
    Family IPR039355 Transcription factor GATA
    Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gata1a-201 (1)    Ensembl 1657
    ncRNA gata1a-002 (1)    Ensembl 730
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gata1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-8.1gata1:gata1-EGFP) gata1a EGFP Danio rerio 1 10
    Tg(-8.1gata1a:mRFP) gata1a mRFP Danio rerio 1 8
    Tg(gata1a:deltaBR-GFP) gata1a GFP Danio rerio 1 3
    Tg(gata1a:DsRed) gata1a DsRed Danio rerio 1 306
    Tg(gata1a:EGFP) gata1a EGFP Danio rerio 5 11
    Tg(gata1a:EGFP-2xPT) gata1a EGFP Danio rerio 9 3
    Tg(gata1a:EGFP-UTR-klfd) gata1a EGFPklf1UTR Danio rerio 10 2
    Tg(gata1a:GFP) gata1a GFP Danio rerio 2 57
    Tg(gata1a:mir30e-2-shRNAEGFP-actb1-DsRed) gata1a actb1DsRedEGFPmir30e-2 Danio rerio 6 2
    Tg(gata1a:RFP) gata1a RFP Danio rerio 1 1
    Tg(gata1a:urod-GFP) gata1a GFPurod Danio rerio 1 3
    Tg(myl7:GFP,U6:CRISPR1-urod,gata1a:zCas9) gata1amyl7 CRISPR1-urodGFPzCas9 Danio rerio 1 1
    Tg(myl7:GFP,U6:GFP,gata1a:zCas9) gata1amyl7 GFPzCas9 Danio rerio 1 1
    Tg2(gata1a:DsRed) gata1a DsRed Danio rerio 1 2
    Tg2(gata1a:GFP) gata1a GFP Danio rerio 1 2
    tg3(gata1a:dsred) gata1a DsRed Danio rerio 1 1
    MARKER RELATIONSHIPS
    gata1a Contained in: [BAC] DKEYP-97E7 (1)
    gata1a Encodes: [EST] eu551 (1)
    [cDNA] MGC:153883 (1), MGC:191963 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131234 (1) 1694 nt
    Genomic GenBank:CR932000 (1) 77992 nt
    Select Tool
    Polypeptide UniProtKB:Q05AJ3 (1) 418 aa
    Sequence Information (all 18)
    ORTHOLOGY for gata1a ( Chr: 11 )
    CITATIONS (559)