ZFIN ID: ZDB-LAB-170220-4
Zhigang Zhou Lab
PI/Director: Zhou, Zhigang
Co-PI / Senior
He, Suxu
Ran, Chao
Yang, Yalin
Contact Person: Zhou, Zhigang
Email: zhouzhigang@caas.cn
Address: Sino-Norway Joint Lab on Fish Gut Microbiota Rm 205, Suppl. Bldg 3, No. 12 ZhongGuanCun South Street, Haidian, Beijing 100081, China
Country: China
Phone: 86-10-82106073
Fax: 86-10-82106054
Line Designation: None assigned


1. The interaction between gut microbiota and fish host ;
2. Microbial products for sustainable aquaculture.

Zhang, Hongling Post-Doc Ding, Qianwen Graduate Student Hu, Jun Graduate Student
Li, Jie Graduate Student Li, Youshen Graduate Student Li, Yu Graduate Student
Liu, Yu Graduate Student Lu, Chengyao Graduate Student Niu, Wenjing Graduate Student
Qin, Chubin Graduate Student Xie, Yadong Graduate Student Zhang, Fengli Graduate Student
Zhang, Jinxiong Graduate Student Zhang, Zhen Graduate Student Gao, Chenchen Research Staff
Hou, Junxiu Research Staff Li, Dong Research Staff Tang, Shichuan Research Staff

Liang, H., Li, Y., Li, M., Zhou, W., Chen, J., Zhang, Z., Yang, Y., Ran, C., Zhou, Z. (2024) Corrigendum: The effect and underlying mechanism of yeast β-glucan on antiviral resistance of zebrafish against spring viremia of carp virus infection. Frontiers in immunology. 15:13573921357392
Li, S., Yang, H., Jin, Y., Hao, Q., Liu, S., Ding, Q., Yao, Y., Yang, Y., Ran, C., Wu, C., Li, S., Cheng, K., Hu, J., Liu, H., Zhang, Z., Zhou, Z. (2023) Dietary cultured supernatant mixture of Cetobacterium somerae and Lactococcus lactis improved liver and gut health, and gut microbiota homeostasis of zebrafish fed with high-fat diet. Fish & shellfish immunology. 142:109139
Liang, H., Xie, Y., Li, M., Chen, J., Zhou, W., Xia, R., Ding, Q., Yao, Y., Zhang, Z., Yang, Y., Ran, C., Zhou, Z. (2023) The effect of stabilized culture of Lactobacillus rhamnosus GCC-3 on gut and liver health, and anti-viral immunity of zebrafish. Fish & shellfish immunology. 141:109074
Xia, R., Zhang, Q., Xia, D., Hao, Q., Ding, Q., Ran, C., Yang, Y., Cao, A., Zhang, Z., Zhou, Z. (2023) The direct and gut microbiota-mediated effects of dietary bile acids on the improvement of gut barriers in largemouth bass (Micropterus salmoides). Animal nutrition (Zhongguo xu mu shou yi xue hui). 14:324232-42
Yu, Z., Hao, Q., Liu, S.B., Zhang, Q.S., Chen, X.Y., Li, S.H., Ran, C., Yang, Y.L., Teame, T., Zhang, Z., Zhou, Z.G. (2023) The positive effects of postbiotic (SWF concentration®) supplemented diet on skin mucus, liver, gut health, the structure and function of gut microbiota of common carp (Cyprinus carpio) fed with high-fat diet. Fish & shellfish immunology. 135:108681
Zhang, S., Wu, L., Zhang, J., Wang, X., Yang, X., Xin, Y., Chen, L., Li, J., Niu, P. (2023) Multi-omics analysis reveals Mn exposure affects ferroptosis pathway in zebrafish brain. Ecotoxicology and environmental safety. 253:114616114616
Fan, H., Sun, M., Li, J., Zhang, S., Tu, G., Liu, K., Xia, Q., Jiang, Y., Liu, B. (2023) Structure characterization and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix. International journal of biological macromolecules. 233:123502
Huang, Y., Gao, B.Q., Meng, Q., Yang, L.Z., Ma, X.K., Wu, H., Pan, Y.H., Yang, L., Li, D., Chen, L.L. (2023) CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos. Genome biology. 24:1515
Zhao, Y., Hao, Q., Zhang, Q., Yang, Y., Ran, C., Xu, Q., Wu, C., Liu, W., Li, S., Zhang, Z., Zhou, Z. (2022) Nuclease treatment enhanced the ameliorative effect of yeast culture on epidermal mucus, hepatic lipid metabolism, inflammation response and gut microbiota in high-fat diet-fed zebrafish. Fish & shellfish immunology. 131:1182-1191
Li, H., Li, W., Li, J., Li, S., Kuang, L., Pang, F., Jiang, H., Jin, H., Bian, X. (2022) Honokiol Microemulsion Causes Stage-Dependent Toxicity Via Dual Roles in Oxidation-Reduction and Apoptosis through FoxO Signaling Pathway. Cells. 11(22):
Liang, H., Li, Y., Li, M., Zhou, W., Chen, J., Zhang, Z., Yang, Y., Ran, C., Zhou, Z. (2022) The effect and underlying mechanism of yeast β-glucan on antiviral resistance of zebrafish against spring viremia of carp virus infection. Frontiers in immunology. 13:1031962
Jiang, H.Y., Gao, H.Y., Li, J., Zhou, T.Y., Wang, S.T., Yang, J.B., Hao, R.R., Pang, F., Wei, F., Liu, Z.G., Kuang, L., Ma, S.C., He, J.M., Jin, H.T. (2022) Integrated spatially resolved metabolomics and network toxicology to investigate the hepatotoxicity mechanisms of component D of Polygonum multiflorum Thunb. Journal of ethnopharmacology. 298:115630
Yao, Y.Y., Xia, R., Yang, Y.L., Hao, Q., Ran, C., Zhang, Z., Zhou, Z.G. (2022) Study about the combination strategy of Bacillus subtilis wt55 with AiiO-AIO6 to improve the resistance of zebrafish to Aeromonas veronii infection. Fish & shellfish immunology. 128:447-454
Xie, M., Li, Y., Olsen, R.E., Ringø, E., Yang, Y., Zhang, Z., Ran, C., Zhou, Z. (2022) Dietary supplementation of exopolysaccharides from Lactobacillus rhamnosus GCC-3 improved the resistance of zebrafish against spring viremia of carp virus infection. Frontiers in immunology. 13:968348
Xie, M., Hao, Q., Xia, R., Olsen, R.E., Ringø, E., Yang, Y., Zhang, Z., Ran, C., Zhou, Z. (2022) Nuclease-Treated Stabilized Fermentation Product of Cetobacterium somerae Improves Growth, Non-specific Immunity, and Liver Health of Zebrafish (Danio rerio). Frontiers in nutrition. 9:918327
Ding, Q., Lu, C., Hao, Q., Zhang, Q., Yang, Y., Olsen, R.E., Ringo, E., Ran, C., Zhang, Z., Zhou, Z. (2022) Dietary Succinate Impacts the Nutritional Metabolism, Protein Succinylation and Gut Microbiota of Zebrafish. Frontiers in nutrition. 9:894278
Hao, Q., Xia, R., Zhang, Q., Xie, Y., Ran, C., Yang, Y., Zhou, W., Chu, F., Zhang, X., Wang, Y., Zhang, Z., Zhou, Z. (2022) Partially replacing dietary fish meal by Saccharomyces cerevisiae culture improve growth performance, immunity, disease resistance, composition and function of intestinal microbiota in channel catfish (Ictalurus punctatus). Fish & shellfish immunology. 125:220-229
Ding, Q., Hao, Q., Zhang, Q., Yang, Y., Olsen, R.E., Ringø, E., Ran, C., Zhang, Z., Zhou, Z. (2022) Excess DHA Induces Liver Injury via Lipid Peroxidation and Gut Microbiota-Derived Lipopolysaccharide in Zebrafish. Frontiers in nutrition. 9:870343
Wang, S., Bao, J., Li, J., Li, W., Tian, M., Qiu, C., Pang, F., Li, X., Yang, J., Hu, Y., Wang, S., Jin, H. (2022) Fraxinellone Induces Hepatotoxicity in Zebrafish through Oxidative Stress and the Transporters Pathway. Molecules. 27(9):
Ding, Q., Hao, Q., Zhang, Q., Yang, Y., Olsen, R.E., Ringø, E., Ran, C., Zhang, Z., Zhou, Z. (2022) DHA Suppresses Hepatic Lipid Accumulation via Cyclin D1 in Zebrafish. Frontiers in nutrition. 8:797510
Bian, Y., He, M.Y., Ling, Y., Wang, X.J., Zhang, F., Feng, X.S., Zhang, Y., Xing, S.G., Li, J., Qiu, X., Li, Y.R. (2021) Tissue distribution study of perfluorooctanoic acid in exposed zebrafish using MALDI mass spectrometry imaging. Environmental pollution (Barking, Essex : 1987). 293:118505
Xie, M., Xie, Y., Li, Y., Zhou, W., Zhang, Z., Yang, Y., Olsen, R.E., Ringø, E., Ran, C., Zhou, Z. (2021) Stabilized fermentation product of Cetobacterium somerae improves gut and liver health and antiviral immunity of zebrafish. Fish & shellfish immunology. 120:56-66
Zhang, F.L., Yang, Y.L., Zhang, Z., Yao, Y.Y., Xia, R., Gao, C.C., Du, D.D., Hu, J., Ran, C., Liu, Z., Zhou, Z.G. (2021) Surface-Displayed Amuc_1100 From Akkermansia muciniphila on Lactococcus lactis ZHY1 Improves Hepatic Steatosis and Intestinal Health in High-Fat-Fed Zebrafish. Frontiers in nutrition. 8:726108
Chen, X., Li, X., Li, Y. (2021) Toxicity inhibition strategy of microplastics to aquatic organisms through molecular docking, molecular dynamics simulation and molecular modification. Ecotoxicology and environmental safety. 226:112870
Ran, C., Xie, M., Li, J., Xie, Y., Ding, Q., Li, Y., Zhou, W., Yang, Y., Zhang, Z., Olsen, R.E., Zhou, Z. (2021) Dietary Nucleotides Alleviate Hepatic Lipid Deposition via Exogenous AMP-Mediated AMPK Activation in Zebrafish. The Journal of nutrition. 151(10):2986-2996
Gong, B., Guo, Y., Ding, S., Liu, X., Meng, A., Li, D., Jia, S. (2021) A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission. Nature cell biology. 23:782-795
Ding, Q., Zhang, Z., Li, Y., Liu, H., Hao, Q., Yang, Y., Ringø, E., Olsen, R.E., Clarke, J.L., Ran, C., Zhou, Z. (2021) Propionate induces intestinal oxidative stress via Sod2 propionylation in zebrafish. iScience. 24:102515
Wang, X., Ma, X., Wei, G., Ma, W., Zhang, Z., Chen, X., Gao, L., Liu, Z., Yuan, Y., Yi, L., Wang, J., Tokumoto, T., Huang, J., Chen, D., Zhang, J., Liu, J. (2021) The Role of DNA Methylation Reprogramming during Sex Determination and Transition in Zebrafish. Genomics, proteomics & bioinformatics. 19(1):48-63
Wang, A., Zhang, Z., Ding, Q., Yang, Y., Bindelle, J., Ran, C., Zhou, Z. (2021) Intestinal Cetobacterium and acetate modify glucose homeostasis via parasympathetic activation in zebrafish. Gut microbes. 13:1-15
Wu, X., Teame, T., Hao, Q., Ding, Q., Liu, H., Ran, C., Yang, Y., Zhang, Y., Zhou, Z., Duan, M., Zhang, Z. (2020) Use of a paraprobiotic and postbiotic feed supplement (HWF™) improves the growth performance, composition and function of gut microbiota in hybrid sturgeon (Acipenser baerii x Acipenser schrenckii). Fish & shellfish immunology. 104:36-45
Yuan, C., Zhang, C., Qi, Y., Li, D., Hu, Y., Huang, D. (2019) 2,4-Dichlorophenol induced feminization of zebrafish by down-regulating male-related genes through DNA methylation. Ecotoxicology and environmental safety. 189:110042
Zhang, C., Li, D., Ge, T., Han, J., Qi, Y., Huang, D. (2019) 2,4-Dichlorophenol induces feminization of zebrafish (Danio rerio) via DNA methylation. The Science of the total environment. 708:135084
Zhang, Z., Ran, C., Ding, Q.W., Liu, H.L., Xie, M.X., Yang, Y.L., Xie, Y.D., Gao, C.C., Zhang, H.L., Zhou, Z.G. (2019) Ability of prebiotic polysaccharides to activate a HIF1α-antimicrobial peptide axis determines liver injury risk in zebrafish. Communications biology. 2:274
Wu, Y., Huang, J., Deng, M., Jin, Y., Yang, H., Liu, Y., Cao, Q., Mennigen, J.A., Tu, W. (2019) Acute exposure to environmentally relevant concentrations of Chinese PFOS alternative F-53B induces oxidative stress in early developing zebrafish. Chemosphere. 235:945-951
Li, D., March, M.E., Gutierrez-Uzquiza, A., Kao, C., Seiler, C., Pinto, E., Matsuoka, L.S., Battig, M.R., Bhoj, E.J., Wenger, T.L., Tian, L., Robinson, N., Wang, T., Liu, Y., Weinstein, B.M., Swift, M., Jung, H.M., Kaminski, C.N., Chiavacci, R., Perkins, J.A., Levine, M.A., Sleiman, P.M.A., Hicks, P.J., Strausbaugh, J.T., Belasco, J.B., Dori, Y., Hakonarson, H. (2019) ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor. Nature medicine. 25(7):1116-1122
Teame, T., Zhang, Z., Ran, C., Zhang, H., Yang, Y., Ding, Q., Xie, M., Gao, C., Ye, Y., Duan, M., Zhou, Z. (2019) The use of zebrafish (Danio rerio) as biomedical models. Animal frontiers : the review magazine of animal agriculture. 9:68-77
Wang, B., Zhang, H., An, J., Zhang, Y., Sun, L., Jin, Y., Shi, J., Li, M., Zhang, H., Zhang, Z. (2019) Sequential Intercellular Delivery Nanosystem for Enhancing ROS-Induced Antitumor Therapy. Nano Letters. 19:3505-3518
Guo, X., Li, J., Ran, C., Wang, A., Xie, M., Xie, Y., Ding, Q., Zhang, Z., Yang, Y., Zhou, Z. (2018) Dietary nucleotides can directly stimulate the immunity of zebrafish independent of the intestinal microbiota. Fish & shellfish immunology. 86:1064-1071
Qin, C., Xie, Y., Wang, Y., Li, S., Ran, C., He, S., Zhou, Z. (2018) Impact of Lactobacillus casei BL23 on the Host Transcriptome, Growth and Disease Resistance in Larval Zebrafish.. Frontiers in Physiology. 9:1245
Ran, C., Qin, C., Xie, M., Zhang, J., Li, J., Xie, Y., Wang, Y., Li, S., Liu, L., Fu, X., Lin, Q., Li, N., Liles, M.R., Zhou, Z. (2018) Aeromonas veronii and aerolysin are important for the pathogenesis of motile aeromonad septicemia in cyprinid fish. Environmental microbiology. 20(9):3442-3456
Ding, Q., Zhang, Z., Ran, C., He, S., Yang, Y., Du, Z., Zhang, J., Zhou, Z. (2018) The Hepatotoxicity of Palmitic Acid in Zebrafish Involves the Intestinal Microbiota. The Journal of nutrition. 148(8):1217-1228
Qin, C., Zhang, Z., Wang, Y., Li, S., Ran, C., Hu, J., Xie, Y., Li, W., Zhou, Z. (2017) EPSP of L. casei BL23 Protected against the Infection Caused by Aeromonas veronii via Enhancement of Immune Response in Zebrafish.. Frontiers in microbiology. 8:2406
He, S., Ran, C., Qin, C., Li, S., Zhang, H., de Vos, W.M., Ringø, E., Zhou, Z. (2017) Anti-Infective Effect of Adhesive Probiotic Lactobacillus in Fish is Correlated With Their Spatial Distribution in the Intestinal Tissue. Scientific Reports. 7:13195
Luo, K., Li, Y., Ai, K., Xia, L., Zhang, J., Hu, W., Gao, W., Guo, L., Qi, Z., Yuan, H., Qiaoqing, X. (2017) Bioinformatics and expression analysis of finTRIM genes in grass carp, Ctenopharyngodon idella. Fish & shellfish immunology. 66:217-223
Luo, K., Li, Y., Xia, L., Hu, W., Gao, W., Guo, L., Tian, G., Qi, Z., Yuan, H., Qiaoqing, X. (2017) Analysis of the expression patterns of the novel large multigene TRIM gene family (finTRIM) in zebrafish. Fish & shellfish immunology. 66:224-230
He, S., Wang, Q., Li, S., Ran, C., Guo, X., Zhang, Z., Zhou, Z. (2017) Antibiotic growth promoter olaquindox increases pathogen susceptibility in fish by inducing gut microbiota dysbiosis. Science China. Life sciences. 60(11):1260-1270
Hai, T., Cao, C., Shang, H., Guo, W., Mu, Y., Yang, S., Zhang, Y., Zheng, Q., Zhang, T., Wang, X., Liu, Y., Kong, Q., Li, K., Wang, D., Qi, M., Hong, Q., Zhang, R., Wang, X., Jia, Q., Wang, X., Qin, G., Li, Y., Luo, A., Jin, W., Yao, J., Huang, J., Zhang, H., Li, M., Xie, X., Zheng, X., Guo, K., Wang, Q., Zhang, S., Li, L., Xie, F., Zhang, Y., Weng, X., Yin, Z., Hu, K., Cong, Y., Zheng, P., Zou, H., Xin, L., Xia, J., Ruan, J., Li, H., Zhao, W., Yuan, J., Liu, Z., Gu, W., Li, M., Wang, Y., Wang, H., Yang, S., Liu, Z., Wei, H., Zhao, J., Zhou, Q., Meng, A. (2017) A pilot study of large-scale production of mutant pigs by ENU mutagenesis. eLIFE. 6
Guo, X., Ran, C., Zhang, Z., He, S., Jin, M., Zhou, Z. (2017) The Growth-Promoting Effect of Dietary Nucleotides in Fish Is Associated with an Intestinal Microbiota-Mediated Reduction in Energy Expenditure. The Journal of nutrition. 147(5):781-788
Cobbina, S.J., Mao, G., Zhao, T., Xu, H., Zhang, Z., Liu, H., Zou, Y., Wu, X., Yang, L. (2017) Modulation of N-Methyl-D-Aspartate Receptors (NMDAR), Bcl-2 and C-Fos Gene Expressions on Exposure to Individual and Mixtures of Low Concentration Metals in Zebrafish (Danio rerio). Archives of environmental contamination and toxicology. 72(3):418-427
Luo, N., Li, H., Xiang, B., Qiao, L., He, J., Ji, Y., Liu, Y., Li, S., Lu, R., Li, Y., Meng, W., Wu, Y., Xu, H., Mo, X. (2016) Syndecan-4 modulates the proliferation of neural cells and the formation of CaP axons during zebrafish embryonic neurogenesis. Scientific Reports. 6:25300
Zhang, S., Li, J., Song, S., Li, J., Tong, R., Zang, Z., Jiang, Q., Cai, L. (2015) Integrated in silico and experimental methods revealed that Arctigenin inhibited angiogenesis and HCT116 cell migration and invasion through regulating the H1F4A and Wnt/β-catenin pathway. Molecular Biosystems. 11:2878-84
Mancias, J.D., Pontano Vaites, L., Nissim, S., Biancur, D.E., Kim, A.J., Wang, X., Liu, Y., Goessling, W., Kimmelman, A.C., Harper, J.W. (2015) Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. eLIFE. 4
Zhao, M., Wan, X., Li, Y., Zhou, W., Peng, L. (2015) Multiplexed 3D FRET imaging in deep tissue of live embryos. Scientific Reports. 5:13991
Qin, Y., Ke, J., Gu, X., Fang, J., Wang, W., Cong, Q., Li, J., Tan, J., Brunzelle, J.S., Zhang, C., Jiang, Y., Melcher, K., Li, J.P., Xu, H.E., Ding, K. (2015) Structural and functional study of D-glucuronyl C5-epimerase. The Journal of biological chemistry. 290:4620-30