ZFIN

ZFIN ID: ZDB-GENE-990415-36

ZFIN ID: ZDB-GENE-990415-36

CITATIONS (78 total)

Gene Name:	complement C3a, tandem duplicate 2
Gene Symbol:	c3a.2

Gaillard, A.L., Mohamad, T., Quan, F.B., de Cian, A., Mosimann, C., Tostivint, H., Pézeron, G. (2023) Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Developmental Biology. 496:36-51

Novichkova, E., Nayak, S., Boussiba, S., Gopas, J., Zilberg, D., Khozin-Goldberg, I. (2023) Dietary Application of the Microalga Lobosphaera incisa P127 Reduces Severity of Intestinal Inflammation, Modulates Gut-Associated Gene Expression and Microbiome in the Zebrafish Model of IBD. Molecular Nutrition & Food Research. 67(6):e2200253

Swaminathan, A., Gliksberg, M., Anbalagan, S., Wigoda, N., Levkowitz, G. (2023) Stress resilience is established during development and is regulated by complement factors. Cell Reports. 42:111973111973

Charlie-Silva, I., Feitosa, N.M., Pontes, L.G., Fernandes, B.H., Nóbrega, R.H., Gomes, J.M.M., Prata, M.N.L., Ferraris, F.K., Melo, D.C., Conde, G., Rodrigues, L.F., Aracati, M.F., Corrêa-Junior, J.D., Manrique, W.G., Superio, J., Garcez, A.S., Conceição, K., Yoshimura, T.M., Núñez, S.C., Eto, S.F., Fernandes, D.C., Freitas, A.Z., Ribeiro, M.S., Nedoluzhko, A., Lopes-Ferreira, M., Borra, R.C., Barcellos, L.J.G., Perez, A.C., Malafaia, G., Cunha, T.M., Belo, M.A.A., Galindo-Villegas, J. (2022) Plasma proteome responses in zebrafish following λ-carrageenan-Induced inflammation are mediated by PMN leukocytes and correlate highly with their human counterparts. Frontiers in immunology. 13:1019201

Chen, Q., Wei, T., Yang, B., Li, S., Ge, L., Zhou, A., Xie, S. (2022) The Impact of Deleting the mitfa gene in Zebrafish on the Intestinal Microbiota Community. Gene. 846:146870

Fierro-Castro, C., Rotllant, J., Cerdá-Reverter, J.M., Tort, L. (2022) Loss-of-function mutations in melanocortin-1 receptor modulate immune response in teleost fishes. Fish & shellfish immunology. 131:838-846

Sehring, I.M., Mohammadi, H.F., Haffner-Luntzer, M., Ignatius, A., Huber-Lang, M., Weidinger, G. (2022) Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses. eLIFE. 11:

Luo, T., Wang, X., Jin, Y. (2021) Low concentrations of imidacloprid exposure induced gut toxicity in adult zebrafish (Danio rerio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 241:108972

Niksirat, H., Siino, V., Steinbach, C., Levander, F. (2021) High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Journal of Proteome Research. 20(8):4075-4088

Pacheco, I., Díaz-Sánchez, S., Contreras, M., Villar, M., Cabezas-Cruz, A., Gortázar, C., de la Fuente, J. (2021) Probiotic Bacteria with High Alpha-Gal Content Protect Zebrafish against Mycobacteriosis. Pharmaceuticals (Basel, Switzerland). 14(7):

Chen, R.Y., Lin, C.J., Liang, S.T., Villalobos, O., Villaflores, O.B., Lou, B., Lai, Y.H., Hsiao, C.D. (2020) UVB Irradiation Induced Cell Damage and Early Onset of Junbb Expression in Zebrafish. Animals : an open access journal from MDPI. 10(6):

Contreras, M., Pacheco, I., Alberdi, P., Díaz-Sánchez, S., Artigas-Jerónimo, S., Mateos-Hernández, L., Villar, M., Cabezas-Cruz, A., de la Fuente, J. (2020) Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model. Frontiers in cellular and infection microbiology. 10:78

Cornet, V., Douxfils, J., Mandiki, S.N.M., Kestemont, P. (2020) Early-life infection with a bacterial pathogen increases expression levels of innate immunity related genes during adulthood in zebrafish. Developmental and comparative immunology. 108:103672

Houseright, R.A., Rosowski, E.E., Lam, P.Y., Tauzin, S.J.M., Mulvaney, O., Dewey, C.N., Huttenlocher, A. (2020) Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage. Scientific Reports. 10:15716

Ji, S., Gong, Q., Zhang, W., Zheng, J., Peng, B., Yang, M. (2020) Recombinant Vibrio parahaemolyticus ghosts protect zebrafish against infection by Vibrio species. Fish & shellfish immunology. 107(Pt A):64-72

Nayak, S., Al Ashhab, A., Zilberg, D., Khozin-Goldberg, I. (2020) Dietary Supplementation with Omega-6 LC-PUFA-Rich Microalgae Regulates Mucosal Immune Response and Promotes Microbial Diversity in the Zebrafish Gut. Biology. 9(6):

Pacheco, I., Contreras, M., Villar, M., Risalde, M.A., Alberdi, P., Cabezas-Cruz, A., Gortázar, C., de la Fuente, J. (2020) Vaccination with Alpha-Gal Protects Against Mycobacterial Infection in the Zebrafish Model of Tuberculosis. Vaccines. 8(2):

Siriyappagouder, P., Galindo-Villegas, J., Dhanasiri, A.K.S., Zhang, Q., Mulero, V., Kiron, V., Fernandes, J.M.O. (2020) Pseudozyma Priming Influences Expression of Genes Involved in Metabolic Pathways and Immunity in Zebrafish Larvae. Frontiers in immunology. 11:978

Siriyappagouder, P., Galindo-Villegas, J., Dhanasiri, A.K.S., Zhang, Q., Mulero, V., Kiron,V., Fernandes, J.M.O. (2020) Pseudozyma Priming Influences Expression of Genes Involved in Metabolic Pathways and Immunity in Zebrafish Larvae. Frontiers in immunology. 11:978

Yang, M.J., Xu, D., Yang, D.X., Li, L., Peng, X.X., Chen, Z.G., Li, H. (2020) Malate enhances survival of zebrafish against Vibrio alginolyticus infection in the same manner as taurine. Virulence. 11:349-364

Lazado, C.C., Nayak, S., Khozin-Goldberg, I., Zilberg, D. (2019) The gut mucosal barrier of zebrafish (Danio rerio) responds to the time-restricted delivery of Lobosphaera incisa-enriched diets. Fish & shellfish immunology. 89:368-377

Li, L., Song, M., Peng, B., Peng, X.X., Li, H. (2019) Identification and innate immunity mechanism of protective immunogens from extracellular proteins of Edwardsiella tarda. Fish & shellfish immunology. 97:41-45

Lin, W., Guo, H., Wang, L., Zhang, D., Wu, X., Li, L., Qiu, Y., Yang, L., Li, D., Tang, R. (2019) Waterborne microcystin-LR exposure induced chronic inflammatory response via MyD88-dependent toll-like receptor signaling pathway in male zebrafish. The Science of the total environment. 702:134969

Lin, W., Guo, H., Wang, L., Zhang, D., Wu, X., Li, L., Qiu, Y., Yang, L., Li, D., Tang, R. (2019) Parental transfer of microcystin-LR induced innate immune dysfunction of zebrafish: A cross-generational study. Environmental science & technology. 54(2):1014-1023

Yi, C.C., Liu, C.H., Chuang, K.P., Chang, Y.T., Hu, S.Y. (2019) A potential probiotic Chromobacterium aquaticum with bacteriocin-like activity enhances the expression of indicator genes associated with nutrient metabolism, growth performance and innate immunity against pathogen infections in zebrafish (Danio rerio). Fish & shellfish immunology. 93:124-134

Zhang, Z., Ran, C., Ding, Q.W., Liu, H.L., Xie, M.X., Yang, Y.L., Xie, Y.D., Gao, C.C., Zhang, H.L., Zhou, Z.G. (2019) Ability of prebiotic polysaccharides to activate a HIF1α-antimicrobial peptide axis determines liver injury risk in zebrafish. Communications biology. 2:274

Cheng, Z.X., Chu, X., Wang, S.N., Peng, X.X., Li, H. (2018) Six genes of ompA family shuffling for development of polyvalent vaccines against Vibrio alginolyticus and Edwardsiella tarda. Fish & shellfish immunology. 75:308-315

Khansari, A.R., Balasch, J.C., Vallejos-Vidal, E., Teles, M., Fierro-Castro, C., Tort, L., Reyes-López, F.E. (2018) Comparative study of stress and immune-related transcript outcomes triggered by Vibrio anguillarum bacterin and air exposure stress in liver and spleen of gilthead seabream (Sparus aurata), zebrafish (Danio rerio) and rainbow trout (Oncorhynchus mykiss). Fish & shellfish immunology. 86:436-448

Lin, W., Guo, H., Wang, L., Zhang, D., Wu, X., Li, L., Li, D., Tang, R. (2018) Nitrite Enhances MC-LR-Induced Changes on Splenic Oxidation Resistance and Innate Immunity in Male Zebrafish. toxins. 10(12):

López, V., Risalde, M.A., Contreras, M., Mateos-Hernández, L., Vicente, J., Gortázar, C., de la Fuente, J. (2018) Heat-inactivated Mycobacterium bovis protects zebrafish against mycobacteriosis. Journal of fish diseases. 41(10):1515-1528

Nayak, S., Khozin-Goldberg, I., Cohen, G., Zilberg, D. (2018) Dietary Supplementation With ω6 LC-PUFA-Rich Algae Modulates Zebrafish Immune Function and Improves Resistance to Streptococcal Infection. Frontiers in immunology. 9:1960

Risalde, M.A., López, V., Contreras, M., Mateos-Hernández, L., Gortázar, C., de la Fuente, J. (2018) Control of mycobacteriosis in zebrafish (Danio rerio) mucosally vaccinated with heat-inactivated Mycobacterium bovis. Vaccine. 36(30):4447-4453

Su, B.C., Lai, Y.W., Chen, J.Y., Pan, C.Y. (2018) Transgenic expression of tilapia piscidin 3 (TP3) in zebrafish confers resistance to Streptococcus agalactiae. Fish & shellfish immunology. 74:235-241

Van Gennip, J.L.M., Boswell, C.W., Ciruna, B. (2018) Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis. Science advances. 4:eaav1781

Wang, S.N., Cheng, Z.X., Ling, X.P., Chu, X., Peng, X.X., Li, H. (2018) Construction, immune protection and innate immune response of shuffled polyvalent ompAs vaccines. Fish & shellfish immunology. 74:325-331

Wu, S.H., Lin, H.J., Lin, W.F., Wu, J.L., Gong, H.Y. (2018) A potent tilapia secreted granulin peptide enhances the survival of transgenic zebrafish infected by Vibrio vulnificus via modulation of innate immunity. Fish & shellfish immunology. 75:74-90

Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613

Gonçalves, A.F., Neves, J.V., Coimbra, J., Rodrigues, P., Vijayan, M.M., Wilson, J.M. (2017) Cortisol plays a role in the high environmental ammonia associated suppression of the immune response in zebrafish. General and comparative endocrinology. 249:32-39

Lin, W., Hou, J., Guo, H., Qiu, Y., Li, L., Li, D., Tang, R. (2017) Dualistic immunomodulation of sub-chronic microcystin-LR exposure on the innate-immune defense system in male zebrafish. Chemosphere. 183:315-322

Mehrdana, F., Kania, P.W., Nazemi, S., Buchmann, K. (2017) Immunomodulatory effects of excretory/secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model. PLoS One. 12:e0181277

Peng, B., Lin, X.P., Wang, S.N., Yang, M.J., Peng, X.X., Li, H. (2017) Polyvalent protective immunogens identified from outer membrane proteins of Vibrio parahaemolyticus and their induced innate immune response. Fish & shellfish immunology. 72:104-110

Takada, N., Omae, M., Sagawa, F., Chi, N.C., Endo, S., Kozawa, S., Sato, T.N. (2017) Re-evaluating functional landscape of the cardiovascular system during development. Biology Open. 6(11):1756-1770

Hostelley, T.L., Lodh, S., Zaghloul, N.A. (2016) Whole organism transcriptome analysis of zebrafish models of Bardet-Biedl Syndrome and Alström Syndrome provides mechanistic insight into shared and divergent phenotypes. BMC Genomics. 17:318

Jiang, C., Wang, P., Li, M., Liu, S., Zhang, S. (2016) Dietary β-glucan enhances the contents of complement component 3 and factor B in eggs of zebrafish. Developmental and comparative immunology. 65:107-13

Cobbina, S.J., Xu, H., Zhao, T., Mao, G., Zhou, Z., Wu, X., Liu, H., Zou, Y., Wu, X., Yang, L. (2015) A multivariate assessment of innate immune-related gene expressions due to exposure to low concentration individual and mixtures of four kinds of heavy metals on zebrafish (Danio rerio) embryos. Fish & shellfish immunology. 47(2):1032-42

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Brudal, E., Ulanova, L.S., Lampe, E.O., Rishovd, A.L., Griffiths, G., Winther-Larsen, H.C. (2014) Establishment of Three Francisella Infections in Zebrafish Embryos at Different Temperatures. Infection and Immunity. 82(6):2180-94

Faikoh, E.N., Hong, Y.H., Hu, S.Y. (2014) Liposome-encapsulated cinnamaldehyde enhances zebrafish (Danio rerio) immunity and survival when challenged with Vibrio vulnificus and Streptococcus agalactiae. Fish & shellfish immunology. 38:15-24

Forn-Cuní, G., Reis, E.S., Dios, S., Posada, D., Lambris, J.D., Figueras, A., Novoa, B. (2014) The Evolution and Appearance of C3 Duplications in Fish Originate an Exclusive Teleost c3 Gene Form with Anti-Inflammatory Activity. PLoS One. 9:e99673

Wang, Y.D., Peng, K.C., Wu, J.L., Chen, J.Y. (2014) Transgenic expression of salmon delta-5 and delta-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity. Fish & shellfish immunology. 39(2):223-30

Xu, H., Shao, X., Zhang, Z., Zou, Y., Wu, X., and Yang, L. (2013) Oxidative stress and immune related gene expression following exposure to di-n-butyl phthalate and diethyl phthalate in zebrafish embryos. Ecotoxicology and environmental safety. 93:39-44

Cuello, S., Ximénez-Embún, P., Ruppen, I., Schonthaler, H.B., Ashman, K., Madrid, Y., Luque-Garcia, J.L., and Cámara, C. (2012) Analysis of protein expression in developmental toxicity induced by MeHg in zebrafish. The Analyst. 137(22):5302-5311

Jin, Y., Zheng, S., and Fu, Z. (2011) Embryonic exposure to cypermethrin induces apoptosis and immunotoxicity in zebrafish (Danio rerio). Fish & shellfish immunology. 30(4-5):1049-54

Pan, C.Y., Peng, K.C., Lin, C.H., and Chen, J.Y. (2011) Transgenic expression of tilapia hepcidin 1-5 and shrimp chelonianin in zebrafish and their resistance to bacterial pathogens. Fish & shellfish immunology. 31(2):275-85

Encinas, P., Rodriguez-Milla, M.A., Novoa, B., Estepa, A., Figueras, A., and Coll, J. (2010) Zebrafish fin immune responses during high mortality infections with viral haemorrhagic septicemia rhabdovirus. A proteomic and transcriptomic approach. BMC Genomics. 11:518

Hsieh, J.C., Pan, C.Y., and Chen, J.Y. (2010) Tilapia hepcidin (TH)2-3 as a transgene in transgenic fish enhances resistance to Vibrio vulnificus infection and causes variations in immune-related genes after infection by different bacterial species. Fish & shellfish immunology. 29(3):430-439

Peng, K.C., Pan, C.Y., Chou, H.N., and Chen, J.Y. (2010) Using an improved Tol2 transposon system to produce transgenic zebrafish with epinecidin-1 which enhanced resistance to bacterial infection. Fish & shellfish immunology. 28(5-6):905-917

Lam, S.H., Mathavan, S., Tong, Y., Li, H., Karuturi, R.K., Wu, Y., Vega, V.B., Liu, E.T., and Gong, Z. (2008) Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. PLoS Genetics. 4(7):e1000121

Wang, Z., Zhang, S., and Wang, G. (2008) Response of complement expression to challenge with lipopolysaccharide in embryos/larvae of zebrafish Danio rerio: Acquisition of immunocompetent complement. Fish & shellfish immunology. 25(3):264-270

Rojo, I., de Ilárduya, O.M., Estonba, A., and Pardo, M.A. (2007) Innate immune gene expression in individual zebrafish after Listonella anguillarum inoculation. Fish & shellfish immunology. 23(6):1285-1293

Phelps, H.A., and Neely, M.N. (2005) Evolution of the Zebrafish Model: From Development to Immunity and Infectious Disease. Zebrafish. 2(2):87-103

Stickney, H.L., Schmutz, J., Woods, I.G., Holtzer, C.C., Dickson, M.C., Kelly, P.D., Myers, R.M., and Talbot, W.S. (2002) Rapid mapping of zebrafish mutations with SNPs and oligonucleotide microarrays. Genome research. 12(12):1929-1934

Gongora, R., Figueroa, F., and Klein, J. (1998) Independent duplications of Bf and C3 complement genes in the zebrafish. Scandinavian journal of immunology. 48:651-658

Additional Citations (15):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

China Zebrafish Resource Center (CZRC) (2017) CZRC Zebrafish Chromosome 1 All-gene Knockout Project (ZKO project) mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.