ZFIN ID: ZDB-GENE-990415-36
Gene Name: complement component c3a, duplicate 2
Gene Symbol: c3a.2    Nomenclature History

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Previous Names: C3-2 (1), c3.2 (1), c3b

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have endopeptidase inhibitor activity. Involved in cellular response to estrogen stimulus. Predicted to localize to extracellular space. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and post-vent region. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3).
Genome Resources: Alliance (1),  Gene:30491 (1),  Ensembl(GRCz11):ENSDARG00000087359 (2)
GENE EXPRESSION
All Expression Data: 12 figures from 8 publications
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH c3a.2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
age related macular degeneration 9 Alliance {Macular degeneration, age-related, 9} 611378
complement component 3 deficiency Alliance C3 deficiency 613779
{Hemolytic uremic syndrome, atypical, susceptibility to, 5} 612925
DISEASE ASSOCIATED WITH c3a.2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cellular response to estrogen stimulus (more)
Cellular Component extracellular region (more)
Molecular Function endopeptidase inhibitor activity (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA c3a.2-201 (1)    Ensembl 5167
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM c3a.2 No data available
MARKER RELATIONSHIPS
c3a.2 Contained in: [BAC] DKEY-76B14 (1) (order this), DKEY-121K17 (1) (order this)
c3a.2 Contains: [SNP] rs3727567 (1), rs3727568 (1), rs3727569 (1), rs3727570 (1), rs3727571 (1), rs3727572 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131243 (1) 5170 nt
Genomic GenBank:AL928676 (1) 176196 nt
Select Tool
Polypeptide UniProtKB:F1QV29 (1) 1656 aa
Sequence Information (all 14)
ORTHOLOGY for c3a.2 ( Chr: 1 )
CITATIONS (55)