Gene

c3a.2

ID
ZDB-GENE-990415-36
Name
complement C3a, tandem duplicate 2
Symbol
c3a.2 Nomenclature History
Previous Names
  • C3-2 (1)
  • c3.2 (1)
  • c3b
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have endopeptidase inhibitor activity. Involved in cellular response to estrogen stimulus. Predicted to localize to extracellular space. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and post-vent region. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; and sickle cell anemia. Orthologous to human C3 (complement C3).
Genome Resources
Note
None
Expression
All Expression Data
12 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With c3a.2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
age related macular degeneration 9 Alliance {Macular degeneration, age-related, 9} 611378
complement component 3 deficiency Alliance C3 deficiency 613779
{Hemolytic uremic syndrome, atypical, susceptibility to, 5} 612925
Associated With c3a.2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019742 Alpha-2-macroglobulin, conserved site
Domain IPR000020 Anaphylatoxin/fibulin
Domain IPR001134 Netrin domain
Domain IPR001599 Alpha-2-macroglobulin
Domain IPR002890 Macroglobulin domain
Domain IPR009048 Alpha-macroglobulin, receptor-binding
Domain IPR011625 Alpha-2-macroglobulin, bait region domain
Domain IPR011626 Alpha-macroglobulin-like, TED domain
Domain IPR018933 Netrin module, non-TIMP type
Domain IPR035815 Complement C3-like, NTR domain
Domain IPR040839 Macroglobulin domain MG4
Domain IPR041425 Complement C3/4/5, macroglobulin domain MG1
Domain IPR041555 Macroglobulin domain MG3
Family IPR035711 Complement C3-like
Homologous_superfamily IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Homologous_superfamily IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR018081 Anaphylatoxin, complement system
Homologous_superfamily IPR036595 Alpha-macroglobulin, receptor-binding domain superfamily
Domain Details Per Protein
Protein Length Alpha-2-macroglobulin Alpha-2-macroglobulin, bait region domain Alpha-2-macroglobulin, conserved site Alpha-macroglobulin-like, TED domain Alpha-macroglobulin, receptor-binding Alpha-macroglobulin, receptor-binding domain superfamily Anaphylatoxin, complement system Anaphylatoxin/fibulin Complement C3/4/5, macroglobulin domain MG1 Complement C3-like Complement C3-like, NTR domain Immunoglobulin-like fold Macroglobulin domain Macroglobulin domain MG3 Macroglobulin domain MG4 Netrin domain Netrin module, non-TIMP type Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid Tissue inhibitor of metalloproteinases-like, OB-fold
UniProtKB:O73758 58
UniProtKB:F1QV29 1656
UniProtKB:Q3MU74 1651
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations