PUBLICATION
Early-life infection with a bacterial pathogen increases expression levels of innate immunity related genes during adulthood in zebrafish
- Authors
- Cornet, V., Douxfils, J., Mandiki, S.N.M., Kestemont, P.
- ID
- ZDB-PUB-200403-15
- Date
- 2020
- Source
- Developmental and comparative immunology 108: 103672 (Journal)
- Registered Authors
- Keywords
- Bacterial challenge, Immune memory, Trained innate immunity, Zebrafish
- MeSH Terms
-
- Aeromonas salmonicida/immunology
- Animals
- Female
- Fish Diseases/immunology*
- Fish Diseases/microbiology
- Immunity, Innate*
- Immunologic Memory*
- Male
- Reinfection/immunology*
- Reinfection/microbiology
- Zebrafish/immunology*
- Zebrafish/microbiology
- PubMed
- 32151677 Full text @ Dev. Comp. Immunol.
Citation
Cornet, V., Douxfils, J., Mandiki, S.N.M., Kestemont, P. (2020) Early-life infection with a bacterial pathogen increases expression levels of innate immunity related genes during adulthood in zebrafish. Developmental and comparative immunology. 108:103672.
Abstract
Early-life exposure to different stressors can lead to various consequences on fish health status in later life development. To evaluate the effects of Aeromonas salmonicida achromogenes infection in the early-life on immunity in adulthood, zebrafish were either early-infected at 18 days post-fertilization (dpf), chronically infected from 18 to 35 dpf, or late infected at 35 dpf and then grown up to 61 dpf to be re-infected with the pathogen. The age of first infection was shown to influence both, level and timing of the immune gene expressions, especially for inflammation-related genes. In addition, evidence for an innate immune memory in zebrafish primarily infected with the pathogen at 35 dpf and re-infected at 61dpf provide new insights to consolidate the concept of a "trained" innate immunity in fish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping