Figure 5—figure supplement 1.

Schematic outline of the Nodal signaling pathway in vertebrates.

(A) Nodal binds to its cell surface receptor in the presence of the co-receptor EGF-CFC, activating the resulting complex. After phosphorylation, the Smad2/Smad4 complex translocates to the nucleus. Upon binding of the transcription factor FoxH1, transcription of Nodal target genes is initiated. (B) Nodal-independent transcription via the same pathway does not require the co-receptor EGF-CFC or the transcription factor FoxH1. (C) Lefty antagonises Nodal function by blocking either its co-receptor, EGF-CFC, or by directly binding to Nodal. Factors that evolved in the ancestor of bilaterians are displayed in red, all other factors evolved in the ancestor of eumetazoans or earlier. Figure modified after Shen, 2007.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Elife