Figure 2—figure supplement 1.

Metazoan poly-zinc finger transcription factor repertoire and evolution.

(A) Reference proteomes of 28 representative metazoans (downloaded from uniprot.org) were scanned for the presence of C2H2 zinc finger proteins. For each species, the number of proteins with ≥6 domains is plotted. (B) Boxplot representation of the number of poly-ZF proteins per genome in non-bilaterian Metazoa (four species) vs. Bilateria (24 species) using scanning results of panel A. (C) Evolutionary origin of poly-ZF proteins. On the basis of our orthology database (BigWenDB), we inferred lineage-specific orthogroups for four lineages, opisthokonts (O), metazoans (M), eumetazoans (Eu), and bilaterians (B), and analysed those orthogroups for the presence of C2H2 poly-ZF proteins with ≥6 domains. The number of such proteins vs. the total number of lineage-specific orthogroups is displayed in red under each node. "O" indicates origin in the ancestor of opisthokonts or earlier.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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