Figure 8.

Protein-protein interaction network of bilaterian-specific proteins.

(A) Uniprot identifiers corresponding to the human orthologues of 150 bilaterian-specific genes (seven OGs had no human orthologues) were uploaded to the STRING database, and their mutual interactions were visualised as a network. Parameters for the displayed PPI network were: minimum required interaction score = 0.4; maximum number of interactors to display in 1st and 2nd shell = 0. Thus, only known and predicted interactions between 83 distinct bilaterian-specific proteins are shown (non-interacting proteins are hidden). Evidence for displayed interactions is colour-coded (see legend). Edge length and node placement are arbitrary. Five subnetworks between bilaterian-specific genes are highlighted in red (A-E, see Results). (B) Bilaterian-specific Nodal subnetwork in the context of metazoan genes. The five members of the Nodal pathway are highlighted by shading. (C, D) Boxplots comparing bilaterian- (B) and metazoan-specific (M) proteins in the full network and Nodal subnetwork for the total number of interactions per protein (C), and for the relative fraction of bilaterian interactions per protein (D).
Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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