ZFIN ID: ZDB-FIG-171227-50
Lu et al., 2014 - Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway. Nature communications   5:5368 Full text @ Nat. Commun.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagents:
Anatomical Terms:
Stage Range: 30%-epiboly to 1-4 somites
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage Range: 30%-epiboly to Prim-5

Fig. 1 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
chrd AB/TU standard conditions 30%-epiboly to 75%-epiboly axial mesoderm ISH
AB/TU + MO2-wnt8a standard conditions 30%-epiboly to 75%-epiboly axial mesoderm ISH
30%-epiboly to 75%-epiboly ventral mesoderm ISH
AB/TU + MO4-tp53 + MO5-lbx2 + MO8-lbx2 standard conditions 30%-epiboly to 75%-epiboly axial mesoderm ISH
30%-epiboly to 75%-epiboly ventral mesoderm ISH
AB/TU + MO4-tp53 + MO6-lbx2 + MO7-lbx2 standard conditions 30%-epiboly to 75%-epiboly axial mesoderm ISH
30%-epiboly to 75%-epiboly ventral mesoderm ISH
eve1 AB/TU standard conditions 30%-epiboly to 75%-epiboly margin ventral region ISH
AB/TU + MO4-tp53 + MO5-lbx2 + MO8-lbx2 standard conditions 30%-epiboly to 75%-epiboly margin ventral region ISH
AB/TU + MO4-tp53 + MO6-lbx2 + MO7-lbx2 standard conditions 30%-epiboly to 75%-epiboly margin ventral region ISH
foxi1 AB/TU standard conditions 30%-epiboly to 75%-epiboly presumptive ectoderm ISH
AB/TU + MO4-tp53 + MO5-lbx2 + MO8-lbx2 standard conditions 30%-epiboly to 75%-epiboly presumptive ectoderm ISH
AB/TU + MO4-tp53 + MO6-lbx2 + MO7-lbx2 standard conditions 30%-epiboly to 75%-epiboly presumptive ectoderm ISH
lbx2 AB/TU standard conditions 30%-epiboly to 75%-epiboly presumptive paraxial mesoderm ISH
30%-epiboly to 75%-epiboly ventral mesoderm ISH
75%-epiboly to 90%-epiboly presumptive paraxial mesoderm ISH
75%-epiboly to 90%-epiboly ventral mesoderm ISH
1-4 somites segmental plate ISH
1-4 somites ventral mesoderm ISH
wnt8a AB/TU standard conditions 30%-epiboly to 75%-epiboly presumptive paraxial mesoderm ISH
30%-epiboly to 75%-epiboly ventral mesoderm ISH
75%-epiboly to 90%-epiboly presumptive paraxial mesoderm ISH
75%-epiboly to 90%-epiboly ventral mesoderm ISH
1-4 somites segmental plate ISH
1-4 somites ventral mesoderm ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
AB/TU + MO2-wnt8a standard conditions 30%-epiboly - 75%-epiboly axial mesoderm chrd expression increased amount, abnormal
30%-epiboly - 75%-epiboly axial mesoderm chrd expression increased distribution, abnormal
30%-epiboly - 75%-epiboly ventral mesoderm chrd expression mislocalised, abnormal
Prim-5 caudal fin posterior region absent, abnormal
Prim-5 caudal fin ventral region absent, abnormal
Prim-5 trunk posterior region absent, abnormal
Prim-5 trunk ventral region absent, abnormal
AB/TU + MO4-tp53 + MO5-lbx2 + MO8-lbx2 standard conditions 30%-epiboly - 75%-epiboly axial mesoderm chrd expression increased amount, abnormal
30%-epiboly - 75%-epiboly axial mesoderm chrd expression increased distribution, abnormal
30%-epiboly - 75%-epiboly margin ventral region eve1 expression decreased amount, abnormal
30%-epiboly - 75%-epiboly margin ventral region eve1 expression decreased distribution, abnormal
30%-epiboly - 75%-epiboly presumptive ectoderm foxi1 expression decreased amount, abnormal
30%-epiboly - 75%-epiboly presumptive ectoderm foxi1 expression decreased distribution, abnormal
30%-epiboly - 75%-epiboly ventral mesoderm chrd expression mislocalised, abnormal
1-4 somites whole organism elongated, abnormal
1-4 somites whole organism wholly dorsalized, abnormal
Prim-5 caudal fin posterior region absent, abnormal
Prim-5 caudal fin ventral region absent, abnormal
Prim-5 trunk posterior region absent, abnormal
Prim-5 trunk ventral region absent, abnormal
AB/TU + MO4-tp53 + MO6-lbx2 + MO7-lbx2 standard conditions 30%-epiboly - 75%-epiboly axial mesoderm chrd expression increased amount, abnormal
30%-epiboly - 75%-epiboly axial mesoderm chrd expression increased distribution, abnormal
30%-epiboly - 75%-epiboly margin ventral region eve1 expression decreased amount, abnormal
30%-epiboly - 75%-epiboly margin ventral region eve1 expression decreased distribution, abnormal
30%-epiboly - 75%-epiboly presumptive ectoderm foxi1 expression decreased amount, abnormal
30%-epiboly - 75%-epiboly presumptive ectoderm foxi1 expression decreased distribution, abnormal
30%-epiboly - 75%-epiboly ventral mesoderm chrd expression mislocalised, abnormal
1-4 somites whole organism elongated, abnormal
1-4 somites whole organism wholly dorsalized, abnormal
Prim-5 caudal fin posterior region absent, abnormal
Prim-5 caudal fin ventral region absent, abnormal
Prim-5 trunk posterior region absent, abnormal
Prim-5 trunk ventral region absent, abnormal
Full text @ Nat. Commun.