ZFIN ID: ZDB-GENE-030505-1
Gene Name: forkhead box i1
Gene Symbol: foxi1    Nomenclature History

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Previous Names: nos, cb724 (1), hearsay, hsy, no soul, quadro (1), quo(l)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity. Involved in several processes, including animal organ development; epidermal cell fate specification; and neuron development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 4. Is expressed in several structures, including ectoderm; epibranchial ganglion; head; neural crest; and neurogenic field. Orthologous to human FOXI1 (forkhead box I1).
Genome Resources: Alliance (1),  Gene:353313 (1),  Ensembl(GRCz11):ENSDARG00000104566 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
em1 Indel Unknown Frameshift SPONTANEOUS
  • Zebrafish International Resource Center (ZIRC) (order this)
  • foxi1_unspecified Unspecified Unknown Unknown
    hi1321Tg Transgenic Insertion 3' UTR Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi1359aTg Transgenic Insertion Exon 2 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi3239Tg Transgenic Insertion Exon 2 Unknown DNA
    hi3747Tg Transgenic Insertion Exon 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m271 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m809 Point Mutation Unknown Missense ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-foxi1
    1
    CRISPR2-foxi1
    1
    CRISPR3-foxi1
    1
    CRISPR4-foxi1
    1
    CRISPR5-foxi1
    1
    CRISPR6-foxi1
    1
    CRISPR7-foxi1
    1
    CRISPR8-foxi1
    1
    MO1-foxi1 N/A 3
    MO2-foxi1 N/A 14
    MO3-foxi1 N/A 1
    MO4-foxi1 N/A 1
    MO5-foxi1 N/A 2
    PHENOTYPE
    Data: 38 figures from 19 publications
    Observed in:
    DISEASE ASSOCIATED WITH foxi1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive nonsyndromic deafness 4 Alliance Enlarged vestibular aqueduct 600791
    DISEASE ASSOCIATED WITH foxi1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 22)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA foxi1-201 (1)    Ensembl 1636
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM foxi1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(HSE-CMV:foxi1,EGFP) CMVHSE EGFPfoxi1 Danio rerio 1 1
    Tg(hsp70l:foxi1) hsp70l foxi1 Danio rerio 1 4
    TgBAC(foxi1:d2EGFP) foxi1 d2EGFP Danio rerio 1 3
    MARKER RELATIONSHIPS
    foxi1 Contained in: [BAC] CH73-329N5 (1)
    foxi1 Encodes: [EST] cb724 (1) (order this)
    [cDNA] MGC:92424 (1), MGC:191985 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_181735 (1) 1597 nt
    Genomic GenBank:CU914622 (1) 112193 nt
    Select Tool
    Polypeptide UniProtKB:Q7T2N8 (1) 419 aa
    Sequence Information (all 18)
    ORTHOLOGY for foxi1 ( Chr: 12 )
    CITATIONS (105)