ZFIN Gene: wnt8a

ZFIN ID: ZDB-GENE-980526-332

ZFIN ID: ZDB-GENE-980526-332

Gene Name:

wingless-type MMTV integration site family, member 8a

Gene Symbol:

wnt8a

Sequence Ontology ID :

SO:0000704

Previous Names:

wnt8.1 (1), wnt8, etID309727.14 (1), wnt8 ORF1 (1), wnt8 ORF2 (1), wu:fa20e02, wu:fe05d07

Location:

Chr: 14 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have frizzled binding activity. Involved in several processes, including animal organ development; gastrulation; and regionalization. Predicted to localize to the extracellular space. ...

GENE EXPRESSION
All Expression Data:	54 figures from 48 publications
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
	adaxial cell anatomical structure blastoderm lower region blastomere epiblast head hypoblast intermediate mesoderm posterior region intermediate mesoderm margin mesoderm oocyte stage I mitochondrial cloud oocyte stage II oocyte stage III post-vent region presumptive paraxial mesoderm presumptive pronephric mesoderm pronephric mesoderm posterior region segmental plate tail bud anatomical region tail bud dorsal region tail bud posterior region tail bud unfertilized egg posterior region unspecified ventral mesoderm whole organism posterior side whole organism ventral region whole organism yolk animal-vegetal axis yolk yolk syncytial layer ventral region
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la011030Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la018995Tg	Transgenic Insertion	Unknown	Unknown	DNA
nub14	Small Deletion	Unknown	Frameshift, Premature Stop	TALEN
nub15	Small Deletion	Unknown	Frameshift, Premature Stop	TALEN
nub16	Small Deletion	Unknown	Frameshift, Premature Stop	TALEN
nub17	Indel	Unknown	Frameshift, Premature Stop	TALEN
nub18	Small Deletion	Unknown	Unknown	TALEN
nub19	Complex	Unknown	Unknown	TALEN
nub20	Complex	Unknown	Unknown	TALEN
nub21	Complex	Unknown	Unknown	TALEN
nub22	Small Deletion	Unknown	Unknown	TALEN
sa1188	Point Mutation	Unknown	Splice Site	ENU
sa11601	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa31997	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35723	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa42419	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa44812	Point Mutation	Unknown	Unknown	ENU

Targeting reagents:

PHENOTYPE

Data:

35 figures from 19 publications

Observed in:

DISEASE ASSOCIATED WITH wnt8a HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH wnt8a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	anterior/posterior pattern specification (more)
Cellular Component	extracellular region (more)
Molecular Function	nucleic acid binding (more)

GO Terms (all 37)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR005817 (1) InterPro:IPR013087 (1) InterPro:IPR013301 (1) InterPro:IPR018161 (1) InterPro:IPR034312 (1)	PROSITE:PS00028 (1) PROSITE:PS00246 (1)	Pfam:PF00110 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
ncRNA	ottdart00000025913 (1)	3207	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	wnt8a-002 (1)	906	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	wnt8a-201 (1)	1680	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	wnt8a-202 (1)	884	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	wnt8a-203 (1)	554	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	wnt8a-204 (1)	1208	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Withdrawn Transcripts
ncRNA	ottdart00000025917 (1)	906	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

SignaFish

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM wnt8a

MARKER RELATIONSHIPS

wnt8aContained in:	[BAC] CH211-11C15 (1) (order this), CH211-232M8 (1) (order this)
wnt8aEncodes:	[EST] fa20e02, fe05d07 [cDNA] MGC:66187 (1) (order this), MGC:191351 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	GenBank:U10869 (1)	3022bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX927327 (1)	182779bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:B8A6B9 (1)	387aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 20)

OTHER wnt8a GENE PAGES

Alliance (1)

VEGA:OTTDARG00000020652 (1)

VEGA:OTTDARG00000020653 (1)

VEGA:OTTDARG00000043343 (1)

Ensembl(GRCz11):ENSDARG00000052910 (1)

Ensembl(GRCz11):ENSDARG00000078507 (1)

ORTHOLOGY for wnt8a (Chr: 14)

CITATIONS (236)

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