ZFIN ID: ZDB-FIG-160427-8
Ahuja et al., 2016 - Id4 functions downstream of Bmp signaling to restrict TCF function in endocardial cells during atrioventricular valve development. Developmental Biology   412(1):71-82 Full text @ Dev. Biol.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Terms:
Stage: Long-pec
PHENOTYPE:
Fish:
Condition:
Observed In:
Stage: Long-pec

Fig. 7

Endothelial overexpression of id4 in id4 mutants can partially rescue their valve phenotype. Although id4-/- (A) generally lack spp1 expression, a subset does exhibit spp1 expression after endothelial specific id4 overexpression (B). Similarly, as compared to id4-/- which show ectopic bmp4 expression (C), id4 mutants with endothelial specific id4 overexpression (D) show reduced misexpression of bmp4. (E) Most of the larvae with endocardial re-expression of id4 in the id4-/- background show mild retrograde blood flow as compared to id4-/- siblings, most of which show high backflow. Scale bars, 100 ┬Ám.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
bmp4 id4bns18/bns18 standard conditions Long-pec atrioventricular canal myocardium ISH
Long-pec cardiac ventricle ISH
spp1 id4bns18/bns18 standard conditions Long-pec atrioventricular canal endocardium ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
id4bns18/bns18 standard conditions Long-pec atrioventricular canal endocardium spp1 expression decreased amount, abnormal
Long-pec cardiac ventricle bmp4 expression mislocalised, abnormal
id4bns18/bns18 heat shock Long-pec blood circulation process quality, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Developmental Biology for permission to reproduce figures from this article. Please note that this material may be protected by copyright.

Reprinted from Developmental Biology, 412(1), Ahuja, S., Dogra, D., Stainier, D.Y., Reischauer, S., Id4 functions downstream of Bmp signaling to restrict TCF function in endocardial cells during atrioventricular valve development, 71-82, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.