ZFIN ID: ZDB-GENE-980528-2059
Gene Name: bone morphogenetic protein 4
Gene Symbol: bmp4
Sequence Ontology ID : SO:0000704

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Previous Names: bmp-4, zbmp-4, etID309887.17 (1), zgc:100779

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(Including Attributions)
Location: Chr: 17 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have cytokine activity and transforming growth factor beta receptor binding activity; involved in several processes, including animal organ development, cloaca development, and embryonic  ...
GENE EXPRESSION
All Expression Data: 264 figures from 205 publications
Directly Submitted Expression Data: 7 figures (27 images) from Thisse et al., 2005 [eu728]
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1149 Point Mutation Unknown Unknown ENU
b1150 Point Mutation Unknown Unknown ENU
b1172 Point Mutation Unknown Premature Stop ENU
la010179Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la013167Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36537 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • st37 Insertion Unknown Unknown
    st72 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 17 figures from 8 publications
    Observed in:
    DISEASE ASSOCIATED WITH bmp4 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    microphthalmia Microphthalmia, syndromic 6 607932
    orofacial cleft 11 Orofacial cleft 11 600625
    DISEASE ASSOCIATED WITH bmp4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of ventral identity (more)
    Cellular Component extracellular region (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 37)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001111 (1)
  • InterPro:IPR001839 (1)
  • InterPro:IPR015615 (1)
  • InterPro:IPR017948 (1)
  • InterPro:IPR029034 (1)
  • PROSITE:PS00250 (1)
  • PROSITE:PS51362 (1)
  • Pfam:PF00019 (1)
  • Pfam:PF00688 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA bmp4-201 (1) 2991
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM bmp4
    MARKER RELATIONSHIPS
    bmp4Contained in: [BAC] CH73-374D11 (1) (order this), CH211-287A24 (1) (order this)
    bmp4Encodes: [EST] eu728 (1)
    [cDNA] MGC:100779 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131342 (1) 2985bp
    Genomic GenBank:CR391996 (1) 66448bp
    Select Tool
    Polypeptide UniProtKB:F1QAD6 (1) 400aa
    Sequence Clusters UniGene:567 (1)
    Sequence Information (all 28)
    OTHER bmp4 GENE PAGES
  • Alliance (1)
  • Gene:30612 (1)
  • VEGA:OTTDARG00000028886 (1)
  • Ensembl(GRCz11):ENSDARG00000019995 (2)
  • ORTHOLOGY for bmp4 (Chr: 17)
    CITATIONS (409)