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General Information
ZIRC
ZFIN ID: ZDB-FIG-160217-16
Xu et al., 2015 - L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome. Human molecular genetics   24(6):1540-55 Full text @ Hum. Mol. Genet.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Condition:
Knockdown Reagents:
Observed In:
Stage: Protruding-mouth

Fig. 2 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-nipbla + MO1-nipblb chemical treatment: L-leucine zwitterion Protruding-mouth eye decreased size, ameliorated
Protruding-mouth head decreased size, ameliorated
Protruding-mouth post-vent region curved, ameliorated
Protruding-mouth trunk decreased length, ameliorated
WT + MO1-smc3 chemical treatment: L-leucine zwitterion Protruding-mouth eye decreased size, ameliorated
Protruding-mouth head decreased size, ameliorated
Protruding-mouth post-vent region curved, ameliorated
Protruding-mouth trunk decreased length, ameliorated
WT + MO2-rad21a chemical treatment: L-leucine zwitterion Protruding-mouth eye decreased size, ameliorated
Protruding-mouth head decreased size, ameliorated
Protruding-mouth post-vent region curved, ameliorated
Protruding-mouth trunk decreased length, ameliorated
rad21ahi2529Tg standard conditions Protruding-mouth eye decreased size, abnormal
Protruding-mouth head decreased size, abnormal
Protruding-mouth post-vent region curved, abnormal
Protruding-mouth whole organism decreased length, abnormal
rad21ahi2529Tg chemical treatment: L-leucine zwitterion Protruding-mouth eye decreased size, ameliorated
Protruding-mouth head decreased size, ameliorated
Protruding-mouth post-vent region curved, ameliorated
Protruding-mouth trunk decreased length, ameliorated
smc1alhi1113aTg standard conditions Protruding-mouth eye decreased size, abnormal
Protruding-mouth head decreased size, abnormal
Protruding-mouth post-vent region curved, abnormal
Protruding-mouth whole organism decreased length, abnormal
smc1alhi1113aTg chemical treatment: L-leucine zwitterion Protruding-mouth eye decreased size, ameliorated
Protruding-mouth head decreased size, ameliorated
Protruding-mouth post-vent region curved, ameliorated
Protruding-mouth trunk decreased length, ameliorated
Full text @ Hum. Mol. Genet.