ZFIN ID: ZDB-FIG-150311-55
Blasky et al., 2014 - Pard3 regulates contact between neural crest cells and the timing of Schwann cell differentiation but is not essential for neural crest migration or myelination. Developmental dynamics : an official publication of the American Association of Anatomists   243(12):1511-23 Full text @ Dev. Dyn.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Days 45-89

Fig. 7 pard3 is not essential for Schwann cell myelination. A,B: Transmission electron micrographs of coronal sections through the trunk region of 8 dpf wild-type (A) and MZpard3fh305 mutant (B) larvae. Motor axons are pseudocolored blue. Areas indicated by dashed boxes are shown at higher magnification in insets. Multiple layers of myelin membrane are evident in both wild-type and mutant. C,D: Lateral views of 50 dpf wild-type (C) and MZpard3fh305 mutant (D) zebrafish. Dashed white line indicates region of coronal sections obtained for electron microscopy. MZpard3fh305 mutants are shortened and display severe body deformation, manifesting as a variable curved body axis. E,F: Transmission electron micrographs of coronal sections through the trunk region of 50 dpf fish. Areas indicated by dashed boxes are shown at higher magnification in insets. Myelin ultrastructure is similar in wild-type (E,E′) and MZpard3fh305 mutant (F,F′). Scale bars = 1 µM in A-D; 0.25 µM in A′,B′,C′,D′.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
pard3abfh305/fh305 standard conditions Days 45-89 whole organism decreased length, abnormal
Days 45-89 whole organism posterior region curved, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Developmental dynamics : an official publication of the American Association of Anatomists for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Dev. Dyn.