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ZIRC
ZFIN ID: ZDB-FIG-121105-11
Bräutigam et al., 2011 - Vertebrate-specific glutaredoxin is essential for brain development. Proc. Natl. Acad. Sci. USA   108(51):20532-7 Full text @ Proc. Natl. Acad. Sci. USA
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Prim-5

Fig. S3

Neuronal apoptosis in embryos is specific for the lack of zebrafish (zf) glutaredoxin (Grx) 2. Costaining of neurons (anti-HuC/D antibody, red) and apoptotic cell death (TUNEL assay, blue) at 24 hours post fertilization (hpf) in embryos with blocked zfGrx2 expression. (A) Apoptosis at 24 hpf in the CNS of embryos lacking zfGrx2 detected by active caspase-3 measurements was rescued by injection of 20 pgembryo capped zfGrx2 mRNA simultaneously to morpholino injection.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-glrx2 standard conditions Prim-5 hindbrain apoptotic, abnormal
Prim-5 neuron apoptotic, abnormal
Prim-5 spinal cord apoptotic, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Proc. Natl. Acad. Sci. USA for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Proc. Natl. Acad. Sci. USA