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ZIRC
ZFIN ID: ZDB-FIG-120905-40
Bräutigam et al., 2011 - Vertebrate-specific glutaredoxin is essential for brain development. Proceedings of the National Academy of Sciences of the United States of America   108(51):20532-7 Full text @ Proc. Natl. Acad. Sci. USA
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Prim-5

Fig. 4

Formation of the axonal network depends on oxidoreductase activity of zfGrx2. Impaired formation of an axonal network (antiacetylated tubulin antibodies) could be rescued by injection of 20 pg/embryo capped zfGrx2 mRNA simultaneously to morpholino injection. Injection of mRNA coding for active site mutants of zfGrx2 (zfGrx2C37S, zfGrx2C40S) did not rescue. Scale bar, 50 µm.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-glrx2 standard conditions Prim-5 central nervous system development disrupted, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Proceedings of the National Academy of Sciences of the United States of America for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Proc. Natl. Acad. Sci. USA