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ZIRC
ZFIN ID: ZDB-FIG-120905-37
Bräutigam et al., 2011 - Vertebrate-specific glutaredoxin is essential for brain development. Proc. Natl. Acad. Sci. USA   108(51):20532-7 Full text @ Proc. Natl. Acad. Sci. USA
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Antibody:
Fish:
Knockdown Reagent:
Anatomical Term:
Stage: Prim-15
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Prim-15

Fig. 1

Knockdown of zfGrx2 induced apoptosis in central nervous system. Injection of a morpholino blocking zfGrx2 translation reduced the levels of the corresponding protein as visualized by whole mount immunohistochemistry (A and B). Loss of zfGrx2 induced apoptosis in the central nervous system as demonstrated by in vivo caspase 3 measurements (C and D) and TUNEL staining (E and F). Scale bar, 50 µm.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
glrx2 Ab1-glrx2 WT standard conditions Prim-15 whole organism IHC
Ab1-glrx2 WT + MO1-glrx2 standard conditions Prim-15 whole organism IHC
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-glrx2 standard conditions Prim-15 apoptotic process increased occurrence, abnormal
Prim-15 central nervous system apoptotic, abnormal
Prim-15 eye apoptotic, abnormal
Prim-15 forebrain apoptotic, abnormal
Prim-15 hindbrain apoptotic, abnormal
Prim-15 spinal cord apoptotic, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Proc. Natl. Acad. Sci. USA for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Proc. Natl. Acad. Sci. USA