header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-FIG-090428-1
Faro et al., 2009 - T-Cell Factor 4 (tcf7l2) Is the Main Effector of Wnt Signaling During Zebrafish Intestine Organogenesis. Zebrafish   6(1):59-68 Full text @ Zebrafish
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Terms:
Stage: Protruding-mouth
PHENOTYPE:
Fish:
Observed In:
Stage: Protruding-mouth

Fig. 1 apcmcr/mcr fish fail to express some differentiation markers in endoderm-derived tissues. Dorsal view of 72 hpf in wild-type (A, C, E, G) and apcmcr/mcr (B, D, F, H) siblings after WISH for intestinal-fatty acid binding protein (i-fabp) (A, B), trypsin (C, D), liver fatty acid binding protein (l-fabp) (E, F), and insulin (G, H). i-fabp and l-fabp expression is absent in apcmcr mutants, whereas trypsin expression is strongly reduced in these embryos: insulin expression is not affected. Arrowhead indicates ectopic expression of insulin marker in apc mutants (H).

Gene Expression Details
Gene Antibody Fish Conditions Stage Qualifier Anatomy Assay
fabp2 WT standard conditions Protruding-mouth enterocyte ISH
apchu745/hu745 standard conditions Protruding-mouth Not Detected intestinal epithelium ISH
fabp10a WT standard conditions Protruding-mouth hepatocyte ISH
apchu745/hu745 standard conditions Protruding-mouth Not Detected liver ISH
ins WT standard conditions Protruding-mouth endocrine pancreas ISH
apchu745/hu745 standard conditions Protruding-mouth endocrine pancreas ISH
prss1 WT standard conditions Protruding-mouth exocrine pancreas ISH
apchu745/hu745 standard conditions Protruding-mouth Not Detected exocrine pancreas ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
apchu745/hu745 standard conditions Protruding-mouth endodermal digestive tract morphogenesis disrupted, abnormal
Protruding-mouth exocrine pancreas development disrupted, abnormal
Protruding-mouth hepatocyte differentiation disrupted, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Zebrafish for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Zebrafish