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ZIRC
ZFIN ID: ZDB-FIG-090428-5
Faro et al., 2009 - T-Cell Factor 4 (tcf7l2) Is the Main Effector of Wnt Signaling During Zebrafish Intestine Organogenesis. Zebrafish   6(1):59-68 Full text @ Zebrafish
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Anatomical Term:
Stage: Long-pec
PHENOTYPE:
Fish:
Observed In:
Stage Range: Long-pec to Day 4

Fig. 5 Compound embryos apcmcr/mcr; tcf4exI/exI display the apc mutant cardiac phenotype. Dorsal view of 48 hpf wild-type (A), apcmcr/mcr (B), and apcmcr/mcr;tcf4exI/exI (C) siblings after WISH for bmp4. Survival of apc tcf4 genotypes at 96 hpf (D). The depletion of Tcf4 in apcmcr/mcr genetic background (gray bars) does not improve the survival of the apc mutant embryos. Values are mean ± standard error of mean; n>25 embryos per category; experiment was triplicated.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
bmp4 WT standard conditions Long-pec myocardium ISH
apchu745/hu745 standard conditions Long-pec myocardium ISH
apchu745/hu745; tcf7l2zf55/zf55 standard conditions Long-pec myocardium ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
apchu745/+; tcf7l2zf55/+ standard conditions Day 4 whole organism viability, normal
apchu745/+; tcf7l2zf55/zf55 standard conditions Day 4 whole organism viability, normal
apchu745/hu745 standard conditions Long-pec atrioventricular valve malformed, abnormal
Long-pec heart decreased contractility, abnormal
Long-pec heart contraction disrupted, abnormal
apchu745/hu745; tcf7l2zf55/+ standard conditions Day 4 whole organism viability, abnormal
apchu745/hu745; tcf7l2zf55/zf55 standard conditions Long-pec atrioventricular valve malformed, abnormal
Long-pec heart decreased contractility, abnormal
Long-pec heart contraction disrupted, abnormal
Day 4 whole organism viability, abnormal
tcf7l2zf55/+ standard conditions Day 4 whole organism viability, normal
Acknowledgments:
ZFIN wishes to thank the journal Zebrafish for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Zebrafish