Gene

ins

ID
ZDB-GENE-980526-110
Name
preproinsulin
Symbol
ins Nomenclature History
Previous Names
  • insa (1)
  • zgc:109842
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have hormone activity. Involved in several processes, including negative regulation of feeding behavior; positive regulation of pancreatic A cell differentiation; and type B pancreatic cell differentiation. Predicted to localize to extracellular region. Is expressed in several structures, including blood plasma; dermal bone; digestive system; endocrine cell; and endoderm. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin).
Genome Resources
Note
None
Expression
All Expression Data
300 figures from 175 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ins Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
maturity-onset diabetes of the young type 10 Alliance Maturity-onset diabetes of the young, type 10 613370
type 1 diabetes mellitus 2 Alliance Diabetes mellitus, insulin-dependent, 2 125852
Diabetes mellitus, permanent neonatal 618858
Hyperproinsulinemia 616214
Associated With ins Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR022353 Insulin, conserved site
Domain IPR016179 Insulin-like
Family IPR004825 Insulin
Family IPR022352 Insulin family
Homologous_superfamily IPR036438 Insulin-like superfamily
Domain Details Per Protein
Protein Length Insulin Insulin, conserved site Insulin family Insulin-like Insulin-like superfamily
UniProtKB:B2GSI0 108
UniProtKB:O73727 108
UniProtKB:Q9DDE5 108
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-ins polyclonal Guinea pig
  • IHC
Biomeda Corporation
7
Ab6-ins polyclonal Guinea pig
  • IHC
Abcam plc
2
Ab1-ins polyclonal Guinea pig
  • IHC
Dako North America, Inc.
28
Ab3-ins polyclonal Guinea pig
  • IHC
Millipore
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations