ZFIN ID: ZDB-GENE-980526-110
Gene Name: preproinsulin
Gene Symbol: ins    Nomenclature History

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Previous Names: insa (1), zgc:109842

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have hormone activity. Involved in several processes, including negative regulation of feeding behavior; positive regulation of pancreatic A cell differentiation; and type B pancreatic cell differentiation. Predicted to localize to extracellular region. Is expressed in several structures, including blood plasma; dermal bone; digestive system; endocrine cell; and endoderm. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin).
Genome Resources: Alliance (1),  Gene:30262 (1),  Ensembl(GRCz11):ENSDARG00000035350 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns102 Small Deletion Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-ins 2
MO1-ins N/A 1
MO2-ins N/A 4
DISEASE ASSOCIATED WITH ins HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
maturity-onset diabetes of the young type 10 Alliance Maturity-onset diabetes of the young, type 10 613370
type 1 diabetes mellitus 2 Alliance Diabetes mellitus, insulin-dependent, 2 125852
Diabetes mellitus, permanent neonatal 618858
Hyperproinsulinemia 616214
DISEASE ASSOCIATED WITH ins VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process response to glucose (more)
Cellular Component extracellular region (more)
Molecular Function hormone activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ins-201 (1)    Ensembl 485
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab2-ins polyclonal Guinea pig IHC Biomeda Corporation
7
Ab6-ins polyclonal Guinea pig IHC Abcam plc
2
Ab1-ins polyclonal Guinea pig IHC Dako North America, Inc.
27
Ab3-ins polyclonal Guinea pig IHC Millipore
4
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ins
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-1.0ins:EGFP) ins EGFP Danio rerio 1 20
Tg(-1.0ins:Hsa.INS-GFP) ins GFP Danio rerioHomo sapiens 1 4
Tg(-1.0ins:Hsa.INS_C43G-GFP) ins GFP Danio rerioHomo sapiens 1 4
Tg(-1.2ins:EGFP) ins EGFP Danio rerio 1 3
Tg(-1.2ins:Hsa.FGF1,myl7:EGFP) insmyl7 EGFP Danio rerioHomo sapiens 1 1
Tg(-1.2ins:Hsa.GCK_V91L,cryaa:TagRFP) cryaains TagRFP Danio rerioHomo sapiens 1 3
Tg(-1.2ins:Hsa.HIST1H2BJ-mCherry) ins mCherry Danio rerioHomo sapiens 1 9
Tg(-1.2ins:HSV.Ul23-GFP) ins GFP Danio rerioHerpes simplex virus 1 3
Tg(-1.2ins:RTTA-ECR) ins ECRRTTA Danio rerio 1 2
Tg(-1.2ins:RTTA-ECR,TETRE:caMmu.Kcnj11-GFP,cryaa:TagRFP) cryaainsTETRE ECRGFPRTTATagRFP Danio rerio 1 2
Tg(-1.2ins:RTTA-ECR,TETRE:dnMmu.Kcnj11-GFP,cryaa:TagRFP) cryaainsTETRE ECRGFPRTTATagRFP Danio rerio 1 4
Tg(-1.2ins:RTTA-ECR,TETRE:Hsa.BID,cryaa:TagRFP) cryaainsTETRE ECRRTTATagRFP Danio rerioHomo sapiens 1 3
Tg(-1.2ins:SEC-Hsa.FGF1,myl7:EGFP) insmyl7 EGFPSEC Danio rerioHomo sapiens 1 1
Tg(-1.5ins:Cre,-0.58cryaa:Venus) cryaains CreVenus Danio rerio 1 6
Tg(-4.0ins:GFP) ins GFP Danio rerio 1 39
Tg(ins:casp8,ins:Crimson) ins casp8Crimson Danio rerio 1 2
tg(ins:cat,ins:hsa.hist1h2bj-mcherry,cryaa:yfp) cryaains catmCherryYFP Danio rerioHomo sapiens 1 1
Tg(ins:CFP-NTR) ins CFPNTR Danio rerio 1 24
Tg(ins:Cre-ERT2,cryaa:Cerulean) cryaains CeruleanCreERT2 Danio rerio 1 1
Tg(ins:dnigf1ra-EGFP) ins EGFPigf1ra Danio rerio 1 3
Tg(ins:DsRed) ins DsRed Danio rerio 2 40
tg(ins:egfp-hsa.hras,cryaa:mcherry) cryaains EGFPmCherry Danio rerioHomo sapiens 1 1
Tg(ins:FLAG-NTR,cryaa:mCherry) cryaains mCherryNTR Danio rerio 1 12
Tg(ins:GAL4) ins GAL4 Danio rerio 1 3
tg(ins:gcamp5) ins GCaMP Danio rerio 1 1
Tg(ins:GCaMP6s,cryaa:RFP) cryaains GCaMPRFP Danio rerio 1 4
Tg(ins:GFP) ins GFP Danio rerio 1 5
Tg(ins:hmgb1-EGFP) ins EGFPhmgb1a Danio rerio 1 6
Tg(ins:Hsa.CDK4_R24C,cryaa:TagRFP) cryaains TagRFP Danio rerioHomo sapiens 1 4
Tg(ins:Hsa.HBEGF_I117V_L148V,ins:Crimson) ins Crimson Danio rerioHomo sapiens 1 1
Tg(ins:Hsa.HIST1H2BJ-GFP) ins GFP Danio rerioHomo sapiens 1 12
tg(ins:il1b,cryaa:mcherry) cryaains il1bmCherry Danio rerio 0 1
tg(ins:il1b-flag,cryaa:mcherry) cryaains FLAGil1bmCherry Danio rerio 1 1
Tg(ins:Kaede) ins Kaede Danio rerio 1 6
Tg(ins:LOX2272-LOXP-Tomato-LOX2272-Cerulean-LOXP-EYFP,cryaa:RFP) cryaains CeruleanEYFPLOX2272LOXPRFPTomato Danio rerio 1 2
Tg(ins:LOXP-BFP-LOXP-DipTox,ins:Hsa.HIST1H2BJ-GFP) ins BFPDipToxGFP Danio rerioHomo sapiens 1 2
tg(ins:loxp-cfp-ntr-loxp-dsred) ins CFPDsRedLOXPNTR Danio rerio 1 1
tg(ins:loxp-gfp-loxp-ma-tomato-2a-dnvegfaa) ins 2AGFPLOXPMATomatovegfaa Danio rerio 1 1
Tg(ins:LOXP-mCherry-LOXP-Hsa.HIST1H2BJ-GFP,cryaa:Cerulean) cryaains CeruleanGFPmCherry Danio rerioHomo sapiens 1 8
tg(ins:loxp-ntr-mcherry-loxp-luciferase) ins LOXPLuciferasemCherryNTR Danio rerio 1 1
Tg(ins:Luciferase,cryaa:mCherry) cryaains LuciferasemCherry Danio rerio 1 2
tg(ins:ly-gcamp6s,ins:hsa.h2b-rfp) ins GCaMPLYRFP Danio rerioHomo sapiens 1 1
tg(ins:ma-tomato-2a) ins 2AMATomato Danio rerio 1 1
tg(ins:ma-tomato-2a-dnvegfaa) ins 2AMATomatovegfaa Danio rerio 0 1
Tg(ins:mAGFP-gmnn,cryaa:mCherry) cryaains gmnnmAGFPmCherry Danio rerio 2 8
Tg(ins:mCherry) ins mCherry Danio rerio 1 18
Tg(ins:mCherry-cdt1,cryaa:Cerulean) cryaains cdt1CeruleanmCherry Danio rerio 1 8
Tg(ins:mKOFP2-cdt1,ins:mAGFP-gmnn) ins cdt1gmnnmAGFPmKOFP2 Danio rerio 1 1
Tg(ins:mKOFP2-Luciferase-NLS,cryaa:CFP) cryaains CFPLuciferasemKOFP2NLS Danio rerio 1 4
Tg(ins:NTR-EGFP) ins EGFPNTR Danio rerio 1 3
Tg(ins:NTR-mCherry) ins mCherryNTR Danio rerio 3 18
Tg(ins:NTR_T41Q_N71S_F124T-P2A-mCherry) ins 2AmCherryNTR Danio rerio 1 1
Tg(ins:PhiYFP,Eco.NfsB,sst2:CFP) inssst2 CFPPhiYFP Danio rerioEscherichia coli 2 3
Tg(ins:PhiYFP-NTR,sst2:TagRFP) inssst2 NTRPhiYFPTagRFP Danio rerio 1 5
Tg(ins:QF,crybb1:ECFP) crybb1ins ECFPQF Danio rerio 1 2
tg(ins:rcamp1.07) ins RCaMP Danio rerio 1 1
Tg(ins:RFP) ins RFP Danio rerio 1 3
Tg(ins:TagRFP) ins TagRFP Danio rerio 1 5
Tg(ins:TagRFP,NLS-mCherry,NTR) ins mCherryNTRTagRFP Danio rerio 1 3
tg(ins:tagrfpt-2a-dnvegfaa) ins 2ATagRFPTvegfaa Danio rerio 1 1
tg(ins:tagrfpt-2a-flt1) ins 2Aflt1TagRFPT Danio rerio 1 1
tg(ins:tagrfpt-2a-insb) ins 2AinsbTagRFPT Danio rerio 1 1
Tg(ins:Venus-gmnn,cryaa:Venus) cryaains gmnnVenus Danio rerio 1 2
Tg(ins:YFP-2A-NTR3,cryaa:mCherry) cryaains 2AmCherryNTRYFP Danio rerio 1 1
Tg(kop:KALTA4-UTRnanos3,CMV:EGFPins-SV40) CMVkop EGFPinsKALTA4nanos3UTR Danio rerio 1 2
Tg(T2Kins:EGFP-mCherry) ins EGFPmCherry Danio rerio 1 2
Tg1(ins:DsRed) ins DsRed Danio rerio 1 2
Tg1(ins:EGFP) ins EGFP Danio rerio 1 4
Tg2(ins:EGFP) ins EGFP Danio rerio 1 4
Tg2(ins:Kaede) ins Kaede Danio rerio 1 2
Tg2(ins:mCherry) ins mCherry Danio rerio 1 1
Tg2(ins:NTR-mCherry) ins mCherryNTR Danio rerio 1 4
Tg3(ins:EGFP) ins EGFP Danio rerio 1 2
Tg3(ins:Kaede) ins Kaede Danio rerio 1 9
MARKER RELATIONSHIPS
ins Contained in: [BAC] CH211-69I14 (1), CH211-139A5 (1)
ins Encodes: [cDNA] MGC:109842 (1), MGC:192614 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131056 (1) 468 nt
Genomic GenBank:AL935065 (1) 167740 nt
Select Tool
Polypeptide UniProtKB:B2GSI0 (1) 108 aa
Sequence Information (all 20)
ORTHOLOGY for ins ( Chr: 5 )
CITATIONS (324)