Gene

prss1

ID
ZDB-GENE-010131-7
Name
serine protease 1
Symbol
prss1 Nomenclature History
Previous Names
  • try (1)
  • trypsin (1)
  • wu:fb57g08 (1)
  • zgc:109701
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to extracellular space. Is expressed in acinar cell; brain; digestive system; exocrine cell; and heart. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to several human genes including PRSS1 (serine protease 1).
Genome Resources
Note
None
Expression
All Expression Data
149 figures from 86 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prss1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
pancreatitis Alliance Pancreatitis, hereditary 167800
Associated With prss1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018114 Serine proteases, trypsin family, histidine active site
Active_site IPR033116 Serine proteases, trypsin family, serine active site
Domain IPR001254 Serine proteases, trypsin domain
Family IPR001314 Peptidase S1A, chymotrypsin family
Homologous_superfamily IPR009003 Peptidase S1, PA clan
Homologous_superfamily IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
Domain Details Per Protein
Protein Length Peptidase S1A, chymotrypsin family Peptidase S1, PA clan Peptidase S1, PA clan, chymotrypsin-like fold Serine proteases, trypsin domain Serine proteases, trypsin family, histidine active site Serine proteases, trypsin family, serine active site
UniProtKB:Q8AV83 243
UniProtKB:Q561Z7 247
UniProtKB:Q9DDE1 146
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations