ZFIN ID: ZDB-GENE-010131-7
Gene Name: serine protease 1
Gene Symbol: prss1    Nomenclature History

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Previous Names: try (1), trypsin (1), wu:fb57g08 (1), zgc:109701

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to extracellular space. Is expressed in acinar cell; brain; digestive system; exocrine cell; and heart. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to several human genes including PRSS1 (serine protease 1).
Genome Resources: Alliance (1),  Gene:65223 (1),  Ensembl(GRCz11):ENSDARG00000042993 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16247 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH prss1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    pancreatitis Alliance Pancreatitis, hereditary 167800
    DISEASE ASSOCIATED WITH prss1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component extracellular space (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prss1-201 (1)    Ensembl 871
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prss1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(prss1:GFP) prss1 GFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    prss1 Contained in: [BAC] DKEYP-84F3 (1)
    prss1 Encodes: [EST] fb57g08, fb60g08 (1) (order this)
    [cDNA] MGC:109701 (1), MGC:193019 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131708 (1) 845 nt
    Genomic GenBank:BX539313 (1) 215158 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q561Z7 (1) 247 aa
    Sequence Information (all 25)
    ORTHOLOGY for prss1 ( Chr: 16 )
    CITATIONS (137)