ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

per2 mutant zebrafish larvae exhibited normal retinal morphology and abnormal photoreceptor ribbon synapses. (A,B) AB-WT and per2^−/− zebrafish larval retinas revealed relatively normal retinal morphology by IHC. Images are LSCM presentations. Larvae at 5 dpf were stained with zpr1 (green) and propidium iodide (PI; red), which label double cones and nuclei (n = 6 animals per genotype). Scale bar = 40 μm. (C–F) per2 mutant zebrafish larvae exhibited abnormal ribbon synapses. (C) In the AB-WT retina, synaptic ribbons (arrows) are associated with the presynaptic membrane via an arciform density (asterisks). (D) In the per2^−/− retina, synaptic ribbons in most of the pedicles appear to be floating in the cytoplasm and are unassociated with an arciform density and the presynaptic membrane. AB-WT (E) had relatively more normal ribbon synapses (asterisks) than those of the per2 mutant (F; n = 3 retina per genotype). Scale bar = 1 μm. (G,H) Expression of cacnf1a and syjn1 was reduced in mutant compared with WT retinas (5 dpf, n = 10 animals per genotype, *P < 0.05 and ***P < 0.001, unpaired two-tailed t-tests). Data represent the mean ± SEM.

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.