Community Action Needed: Please respond to the NIH RFI
Gene

opn1lw1

ID
ZDB-GENE-990604-41
Name
opsin 1 (cone pigments), long-wave-sensitive, 1
Symbol
opn1lw1 Nomenclature History
Previous Names
  • LWS-1 (1)
  • LC opsin (1)
  • rdops
  • red-sensitive opsin (1)
  • zfred
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable G protein-coupled photoreceptor activity. Acts upstream of or within photoperiodism. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in photoreceptor outer segment. Predicted to be integral component of plasma membrane. Is expressed in several structures, including digestive system; endocrine system; heart; photoreceptor cell; and visual system. Human ortholog(s) of this gene implicated in blue cone monochromacy and red color blindness. Orthologous to several human genes including OPN1LW (opsin 1, long wave sensitive).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
59 figures from 36 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With opn1lw1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
blue cone monochromacy Alliance Blue cone monochromacy 303700
red color blindness Alliance Colorblindness, protan 303900
Associated With opn1lw1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR027430 Visual pigments (opsins) retinal binding site
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000378 Opsin red/green sensitive
Family IPR001760 Opsin
Domain Details Per Protein
Protein Length GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like Opsin Opsin red/green sensitive Visual pigments (opsins) retinal binding site
UniProtKB:A0A0N9N7J4 357
UniProtKB:Q7SZY0 357
UniProtKB:Q9W6A7 357
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-opn1lw1 polyclonal Rabbit
  • IHC
18
Ab2-opn1lw1
  • IHC
ABclonal
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations