ZFIN ID: ZDB-GENE-991109-25
Gene Name: opsin 1 (cone pigments), short-wave-sensitive 1
Gene Symbol: opn1sw1    Nomenclature History

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Previous Names: SWS1 (1), uvops, zfuv

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have G protein-coupled photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and phototransduction. Predicted to localize to the integral component of plasma membrane and photoreceptor outer segment. Human ortholog(s) of this gene implicated in blue color blindness. Is expressed in several structures, including digestive system; endocrine system; heart; photoreceptor cell; and visual system. Orthologous to human OPN1SW (opsin 1, short wave sensitive).
Genome Resources: Alliance (1),  Gene:30582 (1),  Ensembl(GRCz11):ENSDARG00000045677 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-opn1sw1 N/A 1
PHENOTYPE
Data: Fig. 9 from Yoshimatsu et al., 2014
Observed in:
DISEASE ASSOCIATED WITH opn1sw1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
blue color blindness Alliance Colorblindness, tritan 190900
DISEASE ASSOCIATED WITH opn1sw1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process G protein-coupled receptor signaling pathway (more)
Cellular Component integral component of membrane (more)
Molecular Function G protein-coupled receptor activity (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR001521 Opsin, blue sensitive
Family IPR001760 Opsin
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Binding_site IPR027430 Visual pigments (opsins) retinal binding site
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA opn1sw1-201 (1)    Ensembl 1777
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-opn1sw1 polyclonal Rabbit IHC, WB 36
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM opn1sw1
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-5.5opn1sw1:EGFP) opn1sw1 EGFP Danio rerio 1 33
Tg(opn1sw1:GAL4-VP16) opn1sw1 GAL4VP16 Danio rerio 1 4
Tg(opn1sw1:h2az2a-YFP) opn1sw1 h2az2aYFP Danio rerio 1 3
Tg(opn1sw1:KALTA4) opn1sw1 KALTA4 Danio rerio 1 3
Tg(opn1sw1:mCherry) opn1sw1 mCherry Danio rerio 1 1
Tg(opn1sw1:NTR-CFP) opn1sw1 CFPNTR Danio rerio 1 1
Tg(opn1sw1:NTR-mCherry) opn1sw1 mCherryNTR Danio rerio 1 2
Tg(opn1sw1:RTTA,TETRE:EGFP) opn1sw1 EGFPRTTATETRE Danio rerio 1 2
Tg(opn1sw1:RTTA-FLAG) opn1sw1 FLAGRTTA Danio rerio 1 2
Tg(opn1sw1:tetxlc-CFP) opn1sw1 CFPtetxlc Danio rerio 1 3
Tg(opn1sw1:Tomato-Xla.Rho) opn1sw1 Tomato Danio rerioXenopus laevis 1 1
MARKER RELATIONSHIPS
opn1sw1 Contained in: [BAC] CH211-266A5 (1)
opn1sw1 Encodes: [cDNA] MGC:73050 (1), MGC:85903 (1), MGC:173963 (1)
opn1sw1 Has Artifact: [cDNA] MGC:103666
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131319 (1) 1779 bp
Genomic GenBank:BX465210 (1) 171708 bp
Select Tool
Polypeptide UniProtKB:Q6NW86 (1) 336 aa
Sequence Information (all 29)
ORTHOLOGY for opn1sw1 ( Chr: 4 )
CITATIONS (123)