Baer, L., Barthelson, K., Postlethwait, J.H., Adelson, D.L., Pederson, S.M., Lardelli, M. (2024) Differential allelic representation (DAR) identifies candidate eQTLs and improves transcriptome analysis. PLoS Computational Biology. 20:e1011868e1011868

Barthelson, K., Baer, L., Dong, Y., Hand, M., Pujic, Z., Newman, M., Goodhill, G.J., Richards, R.I., Pederson, S.M., Lardelli, M. (2021) Zebrafish Chromosome 14 Gene Differential Expression in the fmr1^hu2787 Model of Fragile X Syndrome. Frontiers in genetics. 12:625466

Barthelson, K., Newman, M., Nowell, C.J., Lardelli, M. (2021) No observed effect on brain vasculature of Alzheimer's disease-related mutations in the zebrafish presenilin 1 gene. Molecular brain. 14:22

Bernardos, R.L., Lentz, S.I., Wolfe, M.S., and Raymond, P.A. (2005) Notch-Delta signaling is required for spatial patterning and Muller glia differentiation in the zebrafish retina. Developmental Biology. 278(2):381-395

Dong, Y., Newman, M., Pederson, S.M., Barthelson, K., Hin, N., Lardelli, M. (2021) Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer's disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis. BMC Genomics. 22:211

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Gao, D., Wu, M., Wang, C., Wang, Y., Zuo, Z. (2015) Chronic exposure to low benzo[a]pyrene level causes neurodegenerative disease-like syndromes in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 167:200-208

Geudens, I., Herpers, R., Hermans, K., Segura, I., Ruiz de Almodovar, C., Bussmann, J., De Smet, F., Vandevelde, W., Hogan, B.M., Siekmann, A., Claes, F., Moore, J.C., Pistocchi, A.S., Loges, S., Mazzone, M., Mariggi, G., Bruyere, F., Cotelli, F., Kerjaschki, D., Noel, A., Foidart, J.M., Gerhardt, H., Ny, A., Langenberg, T., Lawson, N.D., Duckers, H.J., Schulte-Merker, S., Carmeliet, P., and Dewerchin, M. (2010) Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. Arterioscler. Thromb. Vasc. Biol.. 30(9):1695-1702

Hin, N., Newman, M., Kaslin, J., Douek, A.M., Lumsden, A., Nik, S.H.M., Dong, Y., Zhou, X.F., Mañucat-Tan, N.B., Ludington, A., Adelson, D.L., Pederson, S., Lardelli, M. (2020) Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2. PLoS One. 15:e0227258

Lee, J., Peterson, S.M., Freeman, J.L. (2016) Alzheimer's disease risk genes in wild-type adult zebrafish exhibit gender-specific expression changes during aging. Neurogenetics. 17(3):197-9

Leimer, U., Lun, K., Romig, H., Walter, J., Grunberg, J., Brand, M., and Haass, C. (1999) Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis. Biochemistry. 38(41):13602-13609

Liu, T., Lu, J., Wang, Y., Campbell, W.A., Huang, L., Zhu, J., Xia, W., and Wong, S.T.C. (2006) Computerized image analysis for quantitative neuronal phenotyping in zebrafish. Journal of Neuroscience Methods. 153(2):190-202

Mahendra, C.K., Ser, H.L., Abidin, S.A.Z., Khan, S.U., Pusparajah, P., Htar, T.T., Chuah, L.H., Tang, S.Y., Ming, L.C., Goh, K.W., Kumari, Y., Goh, B.H. (2023) The anti-melanogenic properties of Swietenia macrophylla king. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 162:114659114659

Moussavi-Nik, S.H., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I., Verdile, G., Martins, R.N., Lardelli, M. (2015) Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity. Human molecular genetics. 24(13):3662-78

Newman, M., Halter, L., Lim, A., Lardelli, M. (2017) Mitochondrion to endoplasmic reticulum apposition length in zebrafish embryo spinal progenitors is unchanged in response to perturbations associated with Alzheimer's disease. PLoS One. 12:e0179859

Newman, M., Musgrave, F.I., and Lardelli, M. (2007) Alzheimer disease: Amyloidogenesis, the presenilins and animal models. Biochimica et biophysica acta. Molecular basis of disease. 1772(3):285-297

Newman, M., Nornes, S., Martins, R.N., and Lardelli, M.T. (2012) Robust homeostasis of Presenilin1 protein levels by transcript regulation. Neuroscience letters. 519(1):14-19

Newman, M., Wilson, L., Verdile, G., Lim, A., Khan, I., Moussavi Nik, S.H., Pursglove, S., Chapman, G., Martins, R.N., and Lardelli, M. (2014) Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease. Human molecular genetics. 23(3):602-17

Nornes, S., Groth, C., Camp, E., Ey, P., and Lardelli, M. (2003) Developmental control of Presenilin1 expression, endoproteolysis, and interaction in zebrafish embryos. Experimental cell research. 289(1):124-132

Nornes, S., Newman, M., Wells, S., Verdile, G., Martins, R.N., and Lardelli, M. (2009) Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos. Experimental cell research. 315(16):2791-2801

Shi, W.J., Zhao, J.L., Jiang, Y.X., Huang, G.Y., Liu, Y.S., Zhang, J.N., Ying, G.G. (2017) TRANSCRIPTIONAL AND HISTOLOGICAL ALTERATIONS IN GONAD OF ADULT ZEBRAFISH AFTER EXPOSURE TO THE SYNTHETIC PROGESTIN NORGESTREL. Environmental toxicology and chemistry. 36(12):3267-3276

Sreenivasan, R., Cai, M., Bartfai, R., Wang, X., Christoffels, A., and Orban, L. (2008) Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. PLoS One. 3(3):e1791

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Tung, Y.T., Wang, B.J., Hsu, W.M., Hu, M.K., Her, G.M., Huang, W.P., and Liao, Y.F. (2014) Presenilin-1 regulates the expression of p62 to Govern p62-dependent Tau degradation. Molecular neurobiology. 49(1):10-27

Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433

Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314

Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5

Baer, L., Barthelson, K., Postlethwait, J.H., Adelson, D.L., Pederson, S.M., Lardelli, M. (2024) Differential allelic representation (DAR) identifies candidate eQTLs and improves transcriptome analysis. PLoS Computational Biology. 20:e1011868e1011868

Barazzuol, L., Cieri, D., Facchinello, N., Calì, T., Washbourne, P., Argenton, F., Pizzo, P. (2023) Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer's Disease Pathogenesis. Cells. 12(3):

Park, J., Kim, D.Y., Hwang, G.S., Han, I.O. (2023) Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer's disease neuropathology in adult zebrafish. Journal of neuroinflammation. 20:257257

Barthelson, K., Dong, Y., Newman, M., Lardelli, M. (2021) PRESENILIN 1 Mutations Causing Early-Onset Familial Alzheimer's Disease or Familial Acne Inversa Differ in Their Effects on Genes Facilitating Energy Metabolism and Signal Transduction. Journal of Alzheimer's disease : JAD. 82(1):327-347

Dong, Y., Newman, M., Pederson, S.M., Barthelson, K., Hin, N., Lardelli, M. (2021) Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer's disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis. BMC Genomics. 22:211

Hin, N., Newman, M., Kaslin, J., Douek, A.M., Lumsden, A., Nik, S.H.M., Dong, Y., Zhou, X.F., Mañucat-Tan, N.B., Ludington, A., Adelson, D.L., Pederson, S., Lardelli, M. (2020) Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2. PLoS One. 15:e0227258

Meguro, S., Hosoi, S., Hasumura, T. (2019) High-fat diet impairs cognitive function of zebrafish. Scientific Reports. 9:17063

Wu, S., Song, W., Wong, C.C.L., Shi, Y. (2019) Bax inhibitor 1 is a γ-secretase-independent presenilin-binding protein. Proceedings of the National Academy of Sciences of the United States of America. 116:141147141-147

Liu, J., Sun, L., Zhang, H., Shi, M., Dahlgren, R.A., Wang, X., Wang, H. (2018) Response mechanisms to joint exposure of triclosan and its chlorinated derivatives on zebrafish (Danio rerio) behavior. Chemosphere. 193:820-832

Frank, D.F., Miller, G.W., Connon, R.E., Geist, J., Lein, P.J. (2017) Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95. PeerJ. 5:e4106

Nery, L.R., Silva, N.E., Fonseca, R., Vianna, M.R.M. (2017) Presenilin-1 Targeted Morpholino Induces Cognitive Deficits, Increased Brain Aβ_1-42 and Decreased Synaptic Marker PSD-95 in Zebrafish Larvae.. Neurochemical research. 42(10):2959-2967

Shi, W.J., Zhao, J.L., Jiang, Y.X., Huang, G.Y., Liu, Y.S., Zhang, J.N., Ying, G.G. (2017) TRANSCRIPTIONAL AND HISTOLOGICAL ALTERATIONS IN GONAD OF ADULT ZEBRAFISH AFTER EXPOSURE TO THE SYNTHETIC PROGESTIN NORGESTREL. Environmental toxicology and chemistry. 36(12):3267-3276

Lee, J., Peterson, S.M., Freeman, J.L. (2016) Alzheimer's disease risk genes in wild-type adult zebrafish exhibit gender-specific expression changes during aging. Neurogenetics. 17(3):197-9

Gao, D., Wu, M., Wang, C., Wang, Y., Zuo, Z. (2015) Chronic exposure to low benzo[a]pyrene level causes neurodegenerative disease-like syndromes in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 167:200-208

Shih, Y.H., Zhang, Y., Ding, Y., Ross, C.A., Li, H., Olson, T.M., Xu, X. (2015) Cardiac Transcriptome and Dilated Cardiomyopathy Genes in Zebrafish. Circulation. Cardiovascular genetics. 8(2):261-9

Sreenivasan, R., Jiang, J., Wang, X., Bartfai, R., Kwan, H.Y., Christoffels, A., and Orban, L. (2014) Gonad Differentiation in Zebrafish Is Regulated by the Canonical Wnt Signaling Pathway. Biology of reproduction. 90(2):45

Sundvik, M., Chen, Y.C., and Panula, P. (2013) Presenilin1 Regulates Histamine Neuron Development and Behavior in Zebrafish, Danio rerio. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(4):1589-1597

Wilson, L., and Lardelli, M. (2013) The Development of an in vivo gamma-Secretase Assay using Zebrafish Embryos. Journal of Alzheimer's disease : JAD. 36(3):521-34

Nik, S.H., Wilson, L., Newman, M., Croft, K., Mori, T.A., Musgrave, I., and Lardelli, M. (2012) The BACE1-PSEN-AbetaPP Regulatory Axis has an Ancient Role in Response to Low Oxygen/Oxidative Stress. Journal of Alzheimer's disease : JAD. 28(3):515-530

Newman, M., Tucker, B., Nornes, S., Ward, A., and Lardelli, M. (2009) Altering presenilin gene activity in zebrafish embryos causes changes in expression of genes with potential involvement in Alzheimer's disease pathogenesis. Journal of Alzheimer's disease : JAD. 16(1):133-147

Nornes, S., Newman, M., Verdile, G., Wells, S., Stoick-Cooper, C., Tucker, B., Frederich-Sleptsova, I., Martins, R., and Lardelli, M. (2008) Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity. Human molecular genetics. 17(3):402-412

Newman, M., Musgrave, F.I., and Lardelli, M. (2007) Alzheimer disease: Amyloidogenesis, the presenilins and animal models. Biochimica et biophysica acta. Molecular basis of disease. 1772(3):285-297

Campbell, W.A., Yang, H., Zetterberg, H., Baulac, S., Sears, J.A., Liu, T., Wong, S.T., Zhong, T.P., and Xia, W. (2006) Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. Journal of neurochemistry. 96(5):1423-1440

Bernardos, R.L., Lentz, S.I., Wolfe, M.S., and Raymond, P.A. (2005) Notch-Delta signaling is required for spatial patterning and Muller glia differentiation in the zebrafish retina. Developmental Biology. 278(2):381-395

Nornes, S., Groth, C., Camp, E., Ey, P., and Lardelli, M. (2003) Developmental control of Presenilin1 expression, endoproteolysis, and interaction in zebrafish embryos. Experimental cell research. 289(1):124-132

Groth, C., Nornes, S., McCarty, R., Tamme, R., and Lardelli, M. (2002) Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2. Development genes and evolution. 212(10):486-490

Leimer, U., Lun, K., Romig, H., Walter, J., Grunberg, J., Brand, M., and Haass, C. (1999) Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis. Biochemistry. 38(41):13602-13609