ZFIN ID: ZDB-PUB-021112-3
Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2
Groth, C., Nornes, S., McCarty, R., Tamme, R., and Lardelli, M.
Date: 2002
Source: Development genes and evolution   212(10): 486-490 (Journal)
Registered Authors: Groth, Casper, Lardelli, Michael, McCarty, Rosa, Nornes, Svanhild, Tamme, Richard
Keywords: Alzheimer's disease; presenilin; neural crest; melanocyte; zebrafish
MeSH Terms:
  • Alzheimer Disease/genetics
  • Amino Acid Sequence
  • Animals
  • Blotting, Western
  • Gene Expression Regulation, Developmental*
  • Humans
  • Melanocytes/cytology
  • Melanocytes/physiology*
  • Membrane Proteins/genetics*
  • Membrane Proteins/isolation & purification
  • Molecular Sequence Data
  • Neural Crest
  • Phylogeny
  • Presenilin-2
  • Sequence Homology, Amino Acid
  • Zebrafish/embryology
  • Zebrafish/genetics*
  • Zebrafish/growth & development
PubMed: 12424519 Full text @ Dev. Genes Evol.
Presenilins play prominent roles in the molecular pathogenesis of Alzheimer's disease and during embryo development. We have isolated a zebrafish presenilin orthologue ( pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression is especially high in neural-crest-derived melanocytes.