ZFIN

ZFIN ID: ZDB-GENE-980526-499

ZFIN ID: ZDB-GENE-980526-499

CITATIONS (76 total)

Gene Name:	signal transducer and activator of transcription 1a
Gene Symbol:	stat1a

Li, R.J., Zhuang, Z.J., Qu, Z.Q., Yi, X., Min, Q.W., Yuan, B., Zhou, J.Y., Ba, X.B., Zhao, N., Zhang, B. (2026) Host immune constraints delineate the window of microbial colonization during early development of Larimichthys crocea. Zoological research. 47:173117-31

Liao, B., Chen, M., Huang, Y., Shuai, M., Xu, L., He, S., Huang, H. (2026) Emerging role of KDM5C in X-linked intellectual disability based on human genetic data and zebrafish models. Frontiers in molecular neuroscience. 19:17503111750311

Chen, X., Cui, M., Li, J., Chen, Q., Chen, L., Yang, Z., Fan, Q., Sheng, Y., Lin, R., Ma, Z., Zhao, C. (2025) Evaluation of the safety and efficacy of Sophorae Flavescentis Radix extract in the treatment of inflammatory bowel disease based on zebrafish models. Frontiers in immunology. 16:17227771722777

Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Liu, X., Li, S., Su, B., Dong, Y., Huang, S. (2025) Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell Death & Disease. 16:8484

McLaurin, D.M., Tucker, S.K., Siddique, S.J., Challagundla, L., Gibert, Y., Hebert, M.D. (2025) A Novel Role for Coilin in Vertebrate Innate Immunity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 39:e70580e70580

Raghavan, D., Jeakle, O., Berry, Y., Victor, M., Thummel, R. (2025) Microglia response and function in a chronic model of photoreceptor damage. Frontiers in cell and developmental biology. 13:16992711699271

Ter Horst, S., Siekierska, A., De Meulemeester, A.S., Cuvry, A., Cools, L., Neyts, J., de Witte, P., Rocha-Pereira, J. (2025) The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent. Viruses. 17:

Xiyuan, G., Khaodee, W., Jianghua, Y., Sun, X., Bunpo, P., Yulin, Y., Qing, Y., Cressey, R. (2025) PRKCSH deficiency promotes an anti-tumor immune microenvironment via UPR activation and M1 macrophage polarization. Cancer cell international. :

Weiss, A., D'Amata, C., Pearson, B.J., Hayes, M.N. (2024) A syngeneic spontaneous zebrafish model of tp53-deficient, EGFR^vIII, and PI3KCA^H1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo. eLIFE. 13:

Grabinski, S.E., Parsana, D., Perkins, B.D. (2023) Comparative analysis of transcriptional changes in zebrafish cep290 and bbs2 mutants by RNA-seq reveals upregulation of inflammatory and stress-related pathways. Frontiers in molecular neuroscience. 16:11488401148840

Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350

Wu, J., Li, J., Chen, K., Liu, G., Zhou, Y., Chen, W., Zhu, X., Ni, T.T., Zhang, B., Jin, D., Li, D., Kang, L., Wu, Y., Zhu, P., Xie, P., Zhong, T.P. (2023) Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2209062120e2209062120

Ding, Y., Lang, D., Yan, J., Bu, H., Li, H., Jiao, K., Yang, J., Ni, H., Morotti, S., Le, T., Clark, K.J., Port, J., Ekker, S.C., Cao, H., Zhang, Y., Wang, J., Grandi, E., Li, Z., Shi, Y., Li, Y., Glukhov, A.V., Xu, X. (2022) A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. eLIFE. 11:

Hason, M., Mikulasova, T., Machonova, O., Pombinho, A.R., van Ham, T.J., Irion, U., Nüsslein-Volhard, C., Bartunek, P., Svoboda, O. (2022) M-CSFR/CSF1R signaling regulates myeloid fates in zebrafish via distinct action of its receptors and ligands. Blood advances. 6(5):1474-1488

Kahsay, A., Rodriguez-Marquez, E., López-Pérez, A., Hörnblad, A., von Hofsten, J. (2022) Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models. Scientific Reports. 12:17149

Wang, Y.Y., Nie, L., Xu, X.X., Shao, T., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2022) Essential Role of RIG-I in Hematopoietic Precursor Emergence in Primitive Hematopoiesis during Zebrafish Development. ImmunoHorizons. 6:283-298

Peron, M., Dinarello, A., Meneghetti, G., Martorano, L., Betto, R.M., Facchinello, N., Tesoriere, A., Tiso, N., Martello, G., Argenton, F. (2021) Y705 and S727 are required for mitochondrial import and transcriptional activities of STAT3 and regulate proliferation of embryonic and tissue stem cells. Development (Cambridge, England). 148(17):

Weinreb, J.T., Gupta, V., Sharvit, E., Weil, R., Bowman, T.V. (2021) Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish. Haematologica. 107(3):644-654

Zang, L., Shimada, Y., Nakayama, H., Katsuzaki, H., Kim, Y., Chu, D.C., Juneja, L.R., Kuroyanagi, J., Nishimura, N. (2021) Preventive Effects of Green Tea Extract against Obesity Development in Zebrafish. Molecules. 26(9):

Zhong, S., Li, H., Wang, Y.S., Wang, Y., Ji, G., Li, H.Y., Zhang, S., Liu, Z. (2021) Bmp8a is an essential positive regulator of antiviral immunity in zebrafish. Communications biology. 4:318

Gu, Q., Ali, S.F., Kanungo, J. (2020) Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Journal of applied toxicology : JAT. 41(2):256-264

Peron, M., Dinarello, A., Meneghetti, G., Martorano, L., Facchinello, N., Vettori, A., Licciardello, G., Tiso, N., Argenton, F. (2020) The stem-like STAT3-responsive cells of zebrafish intestine are WNT/β-catenin dependent. Development (Cambridge, England). 147(12):

Chen, M., Luo, Y., Xu, J., Chang, M.X., Liu, J.X. (2019) Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival. Frontiers in immunology. 10:2599

Kulatunga, D.C.M., Dananjaya, S.H.S., Nikapitiya, C., Kim, C.H., Lee, J., De Zoysa, M. (2019) Candida albicans Infection Model in Zebrafish (Danio rerio) for Screening Anticandidal Drugs. Mycopathologia. 184(5):559-572

Xie, Y., Gao, L., Xu, C., Chu, L., Gao, L., Wu, R., Liu, Y., Liu, T., Sun, X.J., Ren, R., Tang, J., Zheng, Y., Zhou, Y., Shen, S. (2019) ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica. 105(4):925-936

Gao, X., Yuan, Y.Y., Lin, Q.F., Xu, J.C., Wang, W.Q., Qiao, Y.H., Kang, D.Y., Bai, D., Xin, F., Huang, S.S., Qiu, S.W., Guan, L.P., Su, Y., Wang, G.J., Han, M.Y., Jiang, Y., Liu, H.K., Dai, P. (2018) Mutation of IFNLR1, an interferon lambda receptor 1, is associated with autosomal-dominant non-syndromic hearing loss.. Journal of Medical Genetics. 55(5):298-306

Zhou, W., Pal, A.S., Hsu, A.Y., Gurol, T., Zhu, X., Wirbisky-Hershberger, S.E., Freeman, J.L., Kasinski, A.L., Deng, Q. (2018) MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation. Cell Reports. 22:1810-1823

Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613

Chernyavskaya, Y., Mudbhary, R., Tokarz, D., Jacob, V., Gopinath, S., Zhang, C., Sun, X., Wang, S., Magnani, E., Madakashira, B.P., Yoder, J.A., Hoshida, Y., Sadler, K.C. (2017) Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling. Development (Cambridge, England). 144(16):2925-2939

Díaz-Pascual, F., Ortíz-Severín, J., Varas, M.A., Allende, M.L., Chávez, F.P. (2017) In vivo Host-Pathogen Interaction as Revealed by Global Proteomic Profiling of Zebrafish Larvae.. Frontiers in cellular and infection microbiology. 7:334

Li, S., Lu, L.F., LaPatra, S.E., Chen, D.D., Zhang, Y.A. (2017) Zebrafish STAT6 negatively regulates IFNφ1 production by attenuating the kinase activity of TANK-binding kinase 1. Developmental and comparative immunology. 67:189-201

Meng, Z.Z., Liu, W., Xia, Y., Yin, H.M., Zhang, C.Y., Su, D., Yan, L.F., Gu, A.H., Zhou, Y. (2017) The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors. Nature communications. 8:14640

Ruan, B.Y., Chen, S.N., Hou, J., Huang, B., Laghari, Z.A., Li, L., Nie, P. (2017) Two type II IFN members, IFN-γ and IFN-γ related (rel), regulate differentially IRF1 and IRF11 in zebrafish. Fish & shellfish immunology. 65:103-110

Zhao, F., Shi, Y., Huang, Y., Zhan, Y., Zhou, L., Li, Y., Wan, Y., Li, H., Huang, H., Ruan, H., Luo, L., Li, L. (2017) Irf8 regulates the progression of myeloproliferative neoplasm (MPN)-like syndrome via Mertk signaling in zebrafish. Leukemia. 32(1):149-158

Yang, C., Li, Z., Kang, W., Tian, Y., Yan, Y., Chen, W. (2016) TET1 and TET3 are essential in induction of Th2-type immunity partly through regulation of IL-4/13A expression in zebrafish model. Gene. 591(1):201-8

Yang, Q., Liu, X., Zhou, T., Cook, J., Nguyen, K., Bai, X. (2016) RNA polymerase II pausing differentially regulates signaling pathway genes to control hematopoietic stem cell emergence in zebrafish. Blood. 128(13):1701-10

Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Feng, H., Zhang, Y., Zhang, Q., Li, Z., Zhang, Q., Gui, J. (2015) Zebrafish IRF1 Regulates IFN Antiviral Response through Binding to IFNϕ1 and IFNϕ3 Promoters Downstream of MyD88 Signaling. Journal of immunology (Baltimore, Md. : 1950). 194(3):1225-38

Merkes, C., Turkalo, T.K., Wilder, N., Park, H., Wenger, L.W., Lewin, S.J., Azuma, M. (2015) Ewing Sarcoma Ewsa Protein Regulates Chondrogenesis of Meckel's Cartilage through Modulation of Sox9 in Zebrafish. PLoS One. 10:e0116627

Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41

Brun, N.R., Lenz, M., Wehrli, B., and Fent, K. (2014) Comparative effects of zinc oxide nanoparticles and dissolved zinc on zebrafish embryos and eleuthero-embryos: importance of zinc ions. The Science of the total environment. 476-477:657-666

Fan, H.B., Liu, Y.J., Wang, L., Du, T.T., Dong, M., Gao, L., Meng, Z.Z., Jin, Y., Chen, Y., Deng, M., Yang, H.T., Jing, Q., Gu, A.H., Liu, T.X., Zhou, Y. (2014) miR-142-3p acts as an essential modulator of neutrophil development in zebrafish. Blood. 124(8):1320-30

Li, Y., Esain, V., Teng, L., Xu, J., Kwan, W., Frost, I.M., Yzaguirre, A.D., Cai, X., Cortes, M., Maijenburg, M.W., Tober, J., Dzierzak, E., Orkin, S.H., Tan, K., North, T.E., Speck, N.A. (2014) Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Genes & Development. 28(23):2597-612

Boltaña, S., Rey, S., Roher, N., Vargas, R., Huerta, M., Huntingford, F.A., Goetzm, F.W., Moore, J., Garcia-Valtanen, P., Estepa, A., and Mackenzie, S. (2013) Behavioural fever is a synergic signal amplifying the innate immune response. Proceedings. Biological sciences. 280(1766):20131381

Liongue, C., O'Sullivan. L.A., Trengove, M.C., and Ward, A.C. (2012) Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS One. 7(3):e32777

Yin, J., Shine, L., Raycroft, F., Deeti, S., Reynolds, A., Ackerman, K.M., Glaviano, A., O'Farrell, S., O'Leary, O., Kilty, C., Kennedy, C., McLoughlin, S., Rice, M., Russell, E., Higgins, D.G., Hyde, D.R., and Kennedy, B.N. (2012) Inhibition of the pim1 oncogene results in diminished visual function. PLoS One. 7(12):e52177

Zhu, L.Y., Pan, P.P., Fang, W., Shao, J.Z., and Xiang, L.X. (2012) Essential Role of IL-4 and IL-4Ralpha Interaction in Adaptive Immunity of Zebrafish: Insight into the Origin of Th2-like Regulatory Mechanism in Ancient Vertebrates. Journal of immunology (Baltimore, Md. : 1950). 188(11):5571-5584

Song, H., Yan, Y.L., Titus, T., He, X., and Postlethwait, J.H. (2011) The role of stat1b in zebrafish hematopoiesis. Mechanisms of Development. 128(7-10):442-56

Wang, W.L., Liu, W., Gong, H.Y., Hong, J.R., Lin, C.C., and Wu, J.L. (2011) Activation of cytokine expression occurs through the tnfα/nf-κb-mediated pathway in birnavirus-infected cells. Fish & shellfish immunology. 31(1):10-21

Li, Z., Xu, X., Huang, L., Wu, J., Lu, Q., Xiang, Z., Liao, J., Weng, S., Yu, X., and He, J. (2010) Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish & shellfish immunology. 29(3):399-406

López-Muñoz, A., Roca, F.J., Meseguer, J., and Mulero, V. (2009) New insights into the evolution of IFNs: zebrafish Group II IFNs induce a rapid and transient expression of IFN-dependent genes and display powerful antiviral activities. Journal of immunology (Baltimore, Md. : 1950). 182(6):3440-3449

Park, E.M., Kang, J.H., Seo, J.S., Kim, G., Chung, J., and Choi, T.J. (2008) Molecular cloning and expression analysis of the STAT1 gene from olive flounder, Paralichthys olivaceus. BMC immunology. 9(1):31

Stein, C., Caccamo, M., Laird, G., and Leptin, M. (2007) Conservation and divergence of gene families encoding components of innate immune response systems in the zebrafish. Genome biology. 8(11):R251

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Oates, A.C., Wollberg, P., Pratt, S.J., Paw, B.H., Johnson, S.L., Ho, R.K., Postlethwait, J.H., Zon, L.I., and Wilks, A.F. (1999) Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stat1 rescues cytokine signaling in a STAT1-deficient human cell line. Developmental Dynamics : an official publication of the American Association of Anatomists. 215(4):352-370

Additional Citations (20):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of EMBL records. Automated Data Submission.