Gene

stat1a

ID

ZDB-GENE-980526-499

Name

signal transducer and activator of transcription 1a

Symbol

stat1a Nomenclature History

Previous Names

stat1

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of transcription by RNA polymerase II; and response to peptide hormone. Predicted to localize to cytosol and nucleus. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; primary immunodeficiency disease; and prostate adenocarcinoma. Is expressed in blood; kidney; and spleen. Orthologous to human STAT1 (signal transducer and activator of transcription 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 11 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With stat1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
chronic mucocutaneous candidiasis	Alliance	Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant	614162
immunodeficiency 31A	Alliance	Immunodeficiency 31A, mycobacteriosis, autosomal dominant	614892
immunodeficiency 31B	Alliance	Immunodeficiency 31B, mycobacterial and viral infections, autosomal recessive	613796
immunodeficiency 31C	Alliance	Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant	614162

Associated With stat1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000980	SH2 domain
Domain	IPR013799	STAT transcription factor, protein interaction
Domain	IPR013800	STAT transcription factor, all-alpha domain
Domain	IPR013801	STAT transcription factor, DNA-binding
Domain	IPR022752	Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal
Domain	IPR035859	STAT1, SH2 domain
Domain	IPR048988	Signal transducer and activator of transcription, linker domain
Family	IPR001217	Transcription factor STAT
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR012345	STAT transcription factor, DNA-binding, N-terminal
Homologous_superfamily	IPR015988	STAT transcription factor, coiled coil
Homologous_superfamily	IPR036535	STAT transcription factor, N-terminal domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily
Homologous_superfamily	IPR038295	STAT1, C-terminal domain superfamily