Gene
stat1a
- ID
- ZDB-GENE-980526-499
- Name
- signal transducer and activator of transcription 1a
- Symbol
- stat1a Nomenclature History
- Previous Names
-
- stat1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of transcription by RNA polymerase II; and response to peptide hormone. Predicted to localize to cytosol and nucleus. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; primary immunodeficiency disease; and prostate adenocarcinoma. Is expressed in blood; kidney; and spleen. Orthologous to human STAT1 (signal transducer and activator of transcription 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 13 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
chronic mucocutaneous candidiasis | Alliance | Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant | 614162 |
immunodeficiency 31A | Alliance | Immunodeficiency 31A, mycobacteriosis, autosomal dominant | 614892 |
immunodeficiency 31B | Alliance | Immunodeficiency 31B, mycobacterial and viral infections, autosomal recessive | 613796 |
immunodeficiency 31C | Alliance | Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant | 614162 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000980 | SH2 domain |
Domain | IPR013799 | STAT transcription factor, protein interaction |
Domain | IPR013800 | STAT transcription factor, all-alpha domain |
Domain | IPR013801 | STAT transcription factor, DNA-binding |
Domain | IPR022752 | Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal |
Domain | IPR035859 | STAT1, SH2 domain |
Domain | IPR048988 | Signal transducer and activator of transcription, linker domain |
Family | IPR001217 | Transcription factor STAT |
Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
Homologous_superfamily | IPR012345 | STAT transcription factor, DNA-binding, N-terminal |
Homologous_superfamily | IPR015988 | STAT transcription factor, coiled coil |
Homologous_superfamily | IPR036535 | STAT transcription factor, N-terminal domain superfamily |
Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Homologous_superfamily | IPR038295 | STAT1, C-terminal domain superfamily |
Domain Details Per Protein
Protein | Length | p53-like transcription factor, DNA-binding domain superfamily | SH2 domain | SH2 domain superfamily | Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal | Signal transducer and activator of transcription, linker domain | STAT1, C-terminal domain superfamily | STAT1, SH2 domain | STAT transcription factor, all-alpha domain | STAT transcription factor, coiled coil | STAT transcription factor, DNA-binding | STAT transcription factor, DNA-binding, N-terminal | STAT transcription factor, N-terminal domain superfamily | STAT transcription factor, protein interaction | Transcription factor STAT |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:O93598
|
749 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
stat1a-201
(1)
|
Ensembl | 4,430 nt |
Interactions and Pathways
No data available
Plasmids
No data available