PUBLICATION
Bmp8a is an essential positive regulator of antiviral immunity in zebrafish
- Authors
- Zhong, S., Li, H., Wang, Y.S., Wang, Y., Ji, G., Li, H.Y., Zhang, S., Liu, Z.
- ID
- ZDB-PUB-210323-14
- Date
- 2021
- Source
- Communications biology 4: 318 (Journal)
- Registered Authors
- Liu, Zhenhui
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Bone Morphogenetic Protein Receptors, Type I/metabolism
- Gene Knockout Techniques
- Host-Pathogen Interactions
- Interferon Regulatory Factor-3/metabolism
- Interferon Type I/immunology
- Interferon Type I/metabolism*
- Phosphorylation
- Protein Serine-Threonine Kinases/metabolism
- Retroviridae/growth & development
- Retroviridae/immunology
- Retroviridae/pathogenicity*
- Retroviridae Infections/genetics
- Retroviridae Infections/immunology
- Retroviridae Infections/metabolism
- Retroviridae Infections/virology*
- Signal Transduction
- Viral Load
- Virus Replication
- Zebrafish/genetics
- Zebrafish/immunology
- Zebrafish/metabolism
- Zebrafish/virology*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- p38 Mitogen-Activated Protein Kinases/metabolism
- PubMed
- 33750893 Full text @ Commun Biol
Citation
Zhong, S., Li, H., Wang, Y.S., Wang, Y., Ji, G., Li, H.Y., Zhang, S., Liu, Z. (2021) Bmp8a is an essential positive regulator of antiviral immunity in zebrafish. Communications biology. 4:318.
Abstract
Bone morphogenetic protein (BMP) is a kind of classical multi-functional growth factor that plays a vital role in the formation and maintenance of bone, cartilage, muscle, blood vessels, and the regulation of adipogenesis and thermogenesis. However, understanding of the role of BMPs in antiviral immunity is still limited. Here we demonstrate that Bmp8a is a newly-identified positive regulator for antiviral immune responses. The bmp8a-/- zebrafish, when infected with viruses, show reduced antiviral immunity and increased viral load and mortality. We also show for the first time that Bmp8a interacts with Alk6a, which promotes the phosphorylation of Tbk1 and Irf3 through p38 MAPK pathway, and induces the production of type I interferons (IFNs) in response to viral infection. Our study uncovers a previously unrecognized role of Bmp8a in regulation of antiviral immune responses and provides a target for controlling viral infection.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping