ZFIN ID: ZDB-GENE-060512-241
CITATIONS (66 total)
Gene Name: forkhead box L2a
Gene Symbol: foxl2a
Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
Wang, C., Chen, X., Dai, Y., Zhang, Y., Sun, Y., Cui, X. (2022) Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. BMC genomic data. 23:39
Zhou, J., Yang, Y.J., Gan, R.H., Wang, Y., Li, Z., Zhang, X.J., Gui, J.F., Zhou, L. (2022) Foxl2a and Foxl2b are involved in midbrain-hindbrain boundary development in zebrafish. Gene expression patterns : GEP. 46:119286
Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
Pierron, F., Lorioux, S., Héroin, D., Daffe, G., Etcheverria, B., Cachot, J., Morin, B., Dufour, S., Gonzalez, P. (2021) Transgenerational epigenetic sex determination: Environment experienced by female fish affects offspring sex ratio. Environmental pollution (Barking, Essex : 1987). 277:116864
Tarashansky, A.J., Musser, J.M., Khariton, M., Li, P., Arendt, D., Quake, S.R., Wang, B. (2021) Mapping single-cell atlases throughout Metazoa unravels cell type evolution. eLIFE. 10:
Bereketoglu, C., Pradhan, A., Olsson, P.E. (2020) Nonsteroidal anti-inflammatory drugs (NSAIDs) cause male-biased sex differentiation in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 223:105476
Ichino, N., Serres, M.R., Urban, R.M., Urban, M.D., Treichel, A.J., Schaefbauer, K.J., Greif, L.E., Varshney, G.K., Skuster, K.J., McNulty, M.S., Daby, C.L., Wang, Y., Liao, H.K., El-Rass, S., Ding, Y., Liu, W., Anderson, J.L., Wishman, M.D., Sabharwal, A., Schimmenti, L.A., Sivasubbu, S., Balciunas, D., Hammerschmidt, M., Farber, S.A., Wen, X.Y., Xu, X., McGrail, M., Essner, J.J., Burgess, S.M., Clark, K.J., Ekker, S.C. (2020) Building the vertebrate codex using the gene breaking protein trap library. eLIFE. 9:
Li, X., Zhang, F., Wu, N., Ye, D., Wang, Y., Zhang, X., Sun, Y., Zhang, Y.A. (2020) A critical role of foxp3a-positive regulatory T cells in maintaining immune homeostasis in zebrafish testis development. Journal of genetics and genomics = Yi chuan xue bao. 47(9):547-561
Peng, L., Fu, W., Wu, X., He, S., Zhao, H., Liu, J., Liu, W., Xiao, Y. (2020) Bisexual Fertile Triploid Zebrafish (Danio rerio): a Rare Case. Marine biotechnology (New York, N.Y.). 22(3):443-455
Romano, S., Kaufman, O.H., Marlow, F.L. (2020) Loss of dmrt1 restores female fates in the absence of cyp19a1a but not rbpms2a/b. Development (Cambridge, England). 147(18):
Yu, G., Liu, X., Zhang, D., Wang, J., Ouyang, G., Chen, Z., Xiao, W. (2020) Zebrafish Nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity. Development (Cambridge, England). 147(18):
Zeng, C.W., Sheu, J.C., Tsai, H.J. (2020) A new member of the forkhead box protein family in zebrafish: Domain composition, phylogenetic implication and embryonic expression pattern. Gene expression patterns : GEP. 35:119093
Zhang, Q., Ye, D., Wang, H., Wang, Y., Sun, Y. (2020) Zebrafish cyp11c1 knockout reveals the roles of 11-ketotestosterone and cortisol in sexual development and reproduction. Endocrinology. 161(6):
Cao, F., Martyniuk, C.J., Wu, P., Zhao, F., Pang, S., Wang, C., Qiu, L. (2019) Long-term exposure to environmental concentrations of azoxystrobin delays sexual development and alters reproduction in zebrafish (Danio rerio). Environmental science & technology. 53(3):1672-1679
Paredes, J.F., Cowan, M., López-Olmeda, J.F., Muñoz-Cueto, J.A., Sánchez-Vázquez, F.J. (2019) Daily rhythms of expression in reproductive genes along the brain-pituitary-gonad axis and liver of zebrafish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 231:158-169
Shi, W.J., Ma, D.D., Jiang, Y.X., Xie, L., Zhang, J.N., Huang, G.Y., Chen, H.X., Hou, L.P., Liu, Y.S., Ying, G.G. (2019) Medroxyprogesterone acetate affects sex differentiation and spermatogenesis in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 212:70-76
Valdivieso, A., Ribas, L., Piferrer, F. (2019) Ovarian transcriptomic signatures of zebrafish females resistant to different environmental perturbations. Journal of experimental zoology. Part B, Molecular and developmental evolution. 332(3-4):55-68
Zhang, C., Li, D., Ge, T., Han, J., Qi, Y., Huang, D. (2019) 2,4-Dichlorophenol induces feminization of zebrafish (Danio rerio) via DNA methylation. The Science of the total environment. 708:135084
Crowder, C.M., Romano, S.N., Gorelick, D.A. (2018) G protein-coupled estrogen receptor is not required for sex determination or ovary function in zebrafish. Endocrinology. 159(10):3515-3523
Hou, L.P., Chen, H., Tian, C.E., Shi, W.J., Liang, Y., Wu, R.R., Fang, X.W., Zhang, C.P., Liang, Y.Q., Xie, L. (2018) The progestin norethindrone affects sex differentiation and alters transcriptional profiles of genes along the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes in juvenile zebrafish Dario renio. Aquatic toxicology (Amsterdam, Netherlands). 201:31-39
Shi, W.J., Jiang, Y.X., Huang, G.Y., Zhao, J.L., Zhang, J.N., Liu, Y.S., Xie, L., Ying, G.G. (2018) Dydrogesterone causes male bias and accelerates sperm maturation in zebrafish (Danio rerio). Environmental science & technology. 52(15):8903-8911
Xu, P., Balczerski, B., Ciozda, A., Louie, K., Oralova, V., Huysseune, A., Crump, J.G. (2018) Fox proteins are modular competency factors for facial cartilage and tooth specification. Development (Cambridge, England). 145(12)
Yang, Q., Yang, X., Liu, J., Chen, Y., Shen, S. (2018) Effects of exposure to BPF on development and sexual differentiation during early life stages of zebrafish (Danio rerio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 210:44-56
Yu, G., Zhang, D., Liu, W., Wang, J., Liu, X., Zhou, C., Gui, J., Xiao, W. (2018) Zebrafish androgen receptor is required for spermatogenesis and maintenance of ovarian function. Oncotarget. 9:24320-24334
Zhou, L., Feng, Y., Wang, F., Dong, X., Jiang, L., Liu, C., Zhao, Q., Li, K. (2018) Generation of all-male-like sterile zebrafish by eliminating primordial germ cells at early development. Scientific Reports. 8:1834
Chen, W., Liu, L., Ge, W. (2017) Expression analysis of growth differentiation factor 9 (Gdf9/gdf9), anti-müllerian hormone (Amh/amh) and aromatase (Cyp19a1a/cyp19a1a) during gonadal differentiation of the zebrafish, Danio rerio†. Biology of reproduction. 96:401-413
Crowder, C.M., Lassiter, C.S., Gorelick, D.A. (2017) Nuclear androgen receptor regulates testes organization and oocyte maturation in zebrafish. Endocrinology. 159(2):980-993
Lee, S.L.J., Horsfield, J.A., Black, M.A., Rutherford, K., Fisher, A., Gemmell, N.J. (2017) Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. BMC Genomics. 18:557
Ribas, L., Liew, W.C., Díaz, N., Sreenivasan, R., Orbán, L., Piferrer, F. (2017) Heat-induced masculinization in domesticated zebrafish is family-specific and yields a set of different gonadal transcriptomes. Proceedings of the National Academy of Sciences of the United States of America. 114(6):E941-E950
Ribas, L., Vanezis, K., Imués, M.A., Piferrer, F. (2017) Treatment with a DNA methyltransferase inhibitor feminizes zebrafish and induces long-term expression changes in the gonads. Epigenetics & chromatin. 10:59
Webster, K.A., Schach, U., Ordaz, A., Steinfeld, J.S., Draper, B.W., Siegfried, K.R. (2017) Dmrt1 is necessary for male sexual development in zebrafish. Developmental Biology. 422(1):33-46
Yang, Y.J., Wang, Y., Li, Z., Zhou, L., Gui, J.F. (2017) Sequential, Divergent, and Cooperative Requirements of Foxl2a and Foxl2b in Ovary Development and Maintenance of Zebrafish.. Genetics. 205(4):1551-1572
Yin, Y., Tang, H., Liu, Y., Chen, Y., Li, G., Liu, X., Lin, H. (2017) Targeted disruption of aromatase reveals dual functions of cyp19a1a during sex differentiation in zebrafish. Endocrinology. 158(9):3030-3041
Chen, S., Zhang, H., Wang, F., Zhang, W., Peng, G. (2016) nr0b1 (DAX1) mutation in zebrafish causes female-to-male sex reversal through abnormal gonadal proliferation and differentiation. Molecular and Cellular Endocrinology. 433:105-16
Di Rosa, V., López-Olmeda, J.F., Burguillo, A., Frigato, E., Bertolucci, C., Piferrer, F., Sánchez-Vázquez, F.J. (2016) Daily Rhythms of the Expression of Key Genes Involved in Steroidogenesis and Gonadal Function in Zebrafish. PLoS One. 11:e0157716
Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
Hua, J., Han, J., Guo, Y., Zhou, B. (2015) The progestin levonorgestrel affects sex differentiation in zebrafish at environmentally relevant concentrations. Aquatic toxicology (Amsterdam, Netherlands). 166:1-9
Tzung, K.W., Goto, R., Saju, J.M., Sreenivasan, R., Saito, T., Arai, K., Yamaha, E., Hossain, M.S., Calvert, M.E., Orbán, L. (2015) Early Depletion of Primordial Germ Cells in Zebrafish Promotes Testis Formation. Stem Cell Reports. 4(1):61-73
Zhang, Z., Lau, S.W., Zhang, L., Ge, W. (2015) Disruption of Zebrafish Follicle-stimulating Hormone Receptor (fshr) but Not Luteinizing Hormone Receptor (lhcgr) Gene by TALEN Leads to Failed Follicle Activation in Females Followed by Sexual Reversal to Males. Endocrinology. 156(10):3747-62
Pradhan, A., Olsson, P.E. (2014) Juvenile Ovary to Testis Transition in Zebrafish Involves Inhibition of Ptges. Biology of reproduction. 91(2):33
Sreenivasan, R., Jiang, J., Wang, X., Bartfai, R., Kwan, H.Y., Christoffels, A., and Orban, L. (2014) Gonad Differentiation in Zebrafish Is Regulated by the Canonical Wnt Signaling Pathway. Biology of reproduction. 90(2):45
Crespo, B., Lan-Chow-Wing, O., Rocha, A., Zanuy, S., Gómez, A. (2013) foxl2 and foxl3 are two ancient paralogs that remain fully functional in teleosts. General and comparative endocrinology. 194:81-93
Zhang, X., Gao, L., Yang, K., Tian, H., Wang, W., and Ru, S. (2013) Monocrotophos pesticide modulates the expression of sexual differentiation genes and causes phenotypic feminization in zebrafish (Danio rerio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 157(1):33-40
Sreenivasan, R., Cai, M., Bartfai, R., Wang, X., Christoffels, A., and Orban, L. (2008) Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. PLoS One. 3(3):e1791
Yaklichkin, S., Vekker, A., Stayrook, S., Lewis, M., and Kessler, D.S. (2007) Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. BMC Genomics. 8(1):201
Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
Additional Citations (19):
ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.
ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.
ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.
ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.
ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.
UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.
ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.
ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.
Ekker, S., Clark, K., ZFIN Staff (2012) Curation of zfishbook links. ZFIN Direct Data Submission.
UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.
Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.
Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.
ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.
ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.
ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.
ZFIN Staff (2003) Curation of orthology data. Manually curated data.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.
ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.