Gene

foxl2a

ID
ZDB-GENE-060512-241
Name
forkhead box L2a
Symbol
foxl2a Nomenclature History
Previous Names
  • foxl2
  • zgc:136549
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in maintenance of animal organ identity. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome and premature ovarian failure. Is expressed in female organism; gonad; ovarian follicle; ovary; and testis. Orthologous to human FOXL2 (forkhead box L2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Yang et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With foxl2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
blepharophimosis, ptosis, and epicanthus inversus syndrome Alliance Blepharophimosis, epicanthus inversus, and ptosis, type 1 110100
blepharophimosis, ptosis, and epicanthus inversus syndrome Alliance Blepharophimosis, epicanthus inversus, and ptosis, type 2 110100
primary ovarian insufficiency 3 Alliance Premature ovarian failure 3 608996
Associated With foxl2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018122 Fork head domain conserved site1
Conserved_site IPR030456 Fork head domain conserved site 2
Domain IPR001766 Fork head domain
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Fork head domain Fork head domain conserved site1 Fork head domain conserved site 2 Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q1JPV2 306
UniProtKB:F8W2R1 104
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations