ZFIN

ZFIN ID: ZDB-GENE-050302-9

ZFIN ID: ZDB-GENE-050302-9

CITATIONS (49 total)

Gene Name:	collagen, type II, alpha 1b
Gene Symbol:	col2a1b

Hanzelova, P., Baird, C., Keshinro, B., Kadhom, R., Lalonde, R.L., Akimenko, M.A. (2026) An essential role for actinotrichia in zebrafish fin patterning and courtship behaviour. Development (Cambridge, England). 153:dev204990

Li, X., Zhou, X., Li, Z., Zhu, Z., Wang, S., Huang, J., Lian, K., Duan, P., Hu, C., Shi, Y. (2026) Therapeutic functions of tanshinone IIA in a zebrafish model of glucocorticoid-induced osteoporosis. Frontiers in pharmacology. 17:1772925

Carcione, A.R., Dale, R.M. (2025) Elucidation of the 5' End of the Zebrafish col2a1b gene at the Telomeric-End of Chromosome 11. microPublication. Biology. 2025:

Debaenst, S., Jarayseh, T., De Saffel, H., Bek, J.W., Boone, M., Josipovic, I., Kibleur, P., Kwon, R.Y., Coucke, P.J., Willaert, A. (2025) Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility. eLIFE. 13:

Morabito, R.M., Tatarakis, D., Swick, R., Stettnisch, S., Nayak, P.K., Schilling, T.F., Horsfield, J.A., Martin, B.L. (2025) The ratio of Wnt signaling activity to Sox2 transcription factor levels predicts neuromesodermal fate potential. Development (Cambridge, England). 152:dev204661

Bao, J., Yu, X., Ping, X., Shentu, X., Zou, J. (2023) Znf469 Plays a Critical Role in Regulating Synthesis of ECM: A Zebrafish Model of Brittle Cornea Syndrome. Investigative ophthalmology & visual science. 64:29

Guillemyn, B., De Saffel, H., Bek, J.W., Tapaneeyaphan, P., De Clercq, A., Jarayseh, T., Debaenst, S., Willaert, A., De Rycke, R., Byers, P.H., Rosseel, T., Coucke, P., Blaumeiser, B., Syx, D., Malfait, F., Symoens, S. (2023) Syntaxin 18 Defects in Human and Zebrafish Unravel Key Roles in Early Cartilage and Bone Development. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 38(11):1718-1730

Sunadome, K., Erickson, A.G., Kah, D., Fabry, B., Adori, C., Kameneva, P., Faure, L., Kanatani, S., Kaucka, M., Dehnisch Ellström, I., Tesarova, M., Zikmund, T., Kaiser, J., Edwards, S., Maki, K., Adachi, T., Yamamoto, T., Fried, K., Adameyko, I. (2023) Directionality of developing skeletal muscles is set by mechanical forces. Nature communications. 14:3060

Zhang, Y., He, L., Yang, Y., Cao, J., Su, Z., Zhang, B., Guo, H., Wang, Z., Zhang, P., Xie, J., Li, J., Ye, J., Zha, Z., Yu, H., Hong, A., Chen, X. (2023) Triclocarban triggers osteoarthritis via DNMT1-mediated epigenetic modification and suppression of COL2A in cartilage tissues. Journal of hazardous materials. 447:130747

Rayrikar, A.Y., Wagh, G.A., Santra, M., Patra, C. (2022) Ccn2a-FGFR1-SHH signaling is necessary for intervertebral disc homeostasis and regeneration in adult zebrafish. Development (Cambridge, England). 150(1):

Sarohi, V., Srivastava, S., Basak, T. (2022) Comprehensive Mapping and Dynamics of Site-Specific Prolyl-Hydroxylation, Lysyl-Hydroxylation and Lysyl O-Glycosylation of Collagens Deposited in ECM During Zebrafish Heart Regeneration. Frontiers in molecular biosciences. 9:892763

Joshi, B., Wagh, G., Kaur, H., Patra, C. (2021) Zebrafish Model to Study Angiotensin II-Mediated Pathophysiology. Biology. 10(11):

Lencer, E., Prekeris, R., Artinger, K.B. (2021) Single-cell RNA analysis identifies pre-migratory neural crest cells expressing markers of differentiated derivatives. eLIFE. 10:

Sun, C.C., Zhou, Z.Q., Chen, Z.L., Zhu, R.K., Yang, D., Peng, X.Y., Zheng, L., Tang, C.F. (2021) Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish. Biology. 10(8):

Tatarakis, D., Cang, Z., Wu, X., Sharma, P.P., Karikomi, M., MacLean, A.L., Nie, Q., Schilling, T.F. (2021) Single-cell transcriptomic analysis of zebrafish cranial neural crest reveals spatiotemporal regulation of lineage decisions during development. Cell Reports. 37:110140

Tsai, Y.W., Jeng, K.S., He, M.K., Hsieh, Y.W., Lai, H.H., Lai, C.Y., Huang, C.C., Chang, C.F., Huang, C.T., Her, G.M. (2021) MXD3 Promotes Obesity and the Androgen Receptor Signaling Pathway in Gender-Disparity Hepatocarcinogenesis. Cells. 10(12):

Sun, J., She, P., Liu, X., Gao, B., Jin, D., Zhong, T.P. (2020) Disruption of Abcc6 Transporter in Zebrafish Causes Ocular Calcification and Cardiac Fibrosis. International Journal of Molecular Sciences. 22(1):

Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117

Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5

Bretaud, S., Nauroy, P., Malbouyres, M., Ruggiero, F. (2018) FISHING FOR COLLAGEN FUNCTION: ABOUT DEVELOPMENT, REGENERATION AND DISEASE. Seminars in cell & developmental biology. 89:100-108

LeBert, D., Squirrell, J.M., Freisinger, C., Rindy, J., Golenberg, N., Frecentes, G., Gibson, A., Eliceiri, K.W., Huttenlocher, A. (2018) Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair.. eLIFE. 7:e30703

Lopez-Baez, J.C., Simpson, D.J., LLeras Forero, L., Zeng, Z., Brunsdon, H., Salzano, A., Brombin, A., Wyatt, C., Rybski, W., Huitema, L.F.A., Dale, R.M., Kawakami, K., Englert, C., Chandra, T., Schulte-Merker, S., Hastie, N.D., Patton, E.E. (2018) Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair.. eLIFE. 7

Egunsola, A.T., Bae, Y., Jiang, M.M., Liu, D.S., Chen-Evenson, Y., Bertin, T., Chen, S., Lu, J.T., Nevarez, L., Magal, N., Raas-Rothschild, A., Swindell, E.C., Cohn, D.H., Gibbs, R.A., Campeau, P.M., Shohat, M., Lee, B.H. (2017) Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia. The Journal of Clinical Investigation. 127(4):1475-1484

Xiong, S., Wu, J, Jing, J., Huang, P., Li, Z., Mei, J., Gui, J.F, (2017) Loss of stat3 function leads to spine malformation and immune disorder in zebrafish. Science Bulletin. 62:Pages 185-196

Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37

Duran, I., Csukasi, F., Taylor, S.P., Krakow, D., Becerra, J., Bombarely, A., Marí-Beffa, M. (2015) Collagen duplicate genes of bone and cartilage participate during regeneration of zebrafish fin skeleton. Gene expression patterns : GEP. 19(1-2):60-9

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Merkes, C., Turkalo, T.K., Wilder, N., Park, H., Wenger, L.W., Lewin, S.J., Azuma, M. (2015) Ewing Sarcoma Ewsa Protein Regulates Chondrogenesis of Meckel's Cartilage through Modulation of Sox9 in Zebrafish. PLoS One. 10:e0116627

Quintana, A.M., Geiger, E.A., Achilly, N., Rosenblatt, D.S., Maclean, K.N., Stabler, S.P., Artinger, K.B., Appel, B., Shaikh, T.H. (2014) Hcfc1b, a zebrafish ortholog of HCFC1, regulates craniofacial development by modulating MMACHC expression. Developmental Biology. 396(1):94-106

Lien, H.W., Yang, C.H., Cheng, C.H., Hung, C.C., Liao, W.H., Hwang, P.P., Han, Y.S., and Huang, C.J. (2013) A Novel Zinc Finger Protein 219-like (ZNF219L) is Involved in the Regulation of Collagen Type 2 Alpha 1a (col2a1a) Gene Expression in Zebrafish Notochord. International journal of biological sciences. 9(9):872-886

Dale, R.M., and Topczewski, J. (2011) Identification of an evolutionarily conserved regulatory element of the zebrafish col2a1a gene. Developmental Biology. 357(2):518-31

Durán, I., Marí-Beffa, M., Santamaría, J.A., Becerra, J., and Santos-Ruiz, L. (2011) Actinotrichia collagens and their role in fin formation. Developmental Biology. 354(1):160-172

Albertson, R.C., Yan, Y.L., Titus, T.A., Pisano, E., Vacchi, M., Yelick, P.C., Detrich, H.W. 3rd, and Postlethwait, J.H. (2010) Molecular pedomorphism underlies craniofacial skeletal evolution in Antarctic notothenioid fishes. BMC Evolutionary Biology. 10:4

Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314

Additional Citations (15):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Manually curated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Manually curated data.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M.S., Lewis, S.E., Thomas, P.D. (2010) Annotation inferences using phylogenetic trees. Automated Data Submission. 12:449-62

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.