PUBLICATION
FISHING FOR COLLAGEN FUNCTION: ABOUT DEVELOPMENT, REGENERATION AND DISEASE
- Authors
- Bretaud, S., Nauroy, P., Malbouyres, M., Ruggiero, F.
- ID
- ZDB-PUB-181013-9
- Date
- 2018
- Source
- Seminars in cell & developmental biology 89: 100-108 (Chapter)
- Registered Authors
- Keywords
- collagenopathies, collagens, development, extracellular matrix, regeneration, zebrafish
- MeSH Terms
-
- Animals
- Collagen/genetics*
- Connective Tissue Diseases/genetics*
- Connective Tissue Diseases/pathology
- Extracellular Matrix/genetics
- Extracellular Matrix Proteins/genetics*
- Humans
- Models, Animal
- Mutation/genetics
- Regeneration/genetics*
- Zebrafish/genetics
- PubMed
- 30312775 Full text @ Sem. Cell Dev. Biol.
Citation
Bretaud, S., Nauroy, P., Malbouyres, M., Ruggiero, F. (2018) FISHING FOR COLLAGEN FUNCTION: ABOUT DEVELOPMENT, REGENERATION AND DISEASE. Seminars in cell & developmental biology. 89:100-108.
Abstract
Collagens are the most abundant vertebrate extracellular matrix proteins. They form a superfamily of 28 members that show a remarkable diversity in molecular and supramolecular organization, tissue distribution and function and mutations in collagen genes result in a wide range of inherited connective tissue diseases. In the recent years, unexpected and very diverse regulatory and mechanical collagen functions have been reported. But the structural and functional landscape of the collagen superfamily is still far from being complete. Zebrafish has emerged over the last decades as a powerful model to interrogate gene function and there are numerous advantages of using zebrafish for collagen research, including recent advances in genome editing technologies and the characterization of the zebrafish matrisome. One can confidently predict that zebrafish will rapidly become a popular vertebrate model to investigate the role of collagens in development, disease and regeneration as discussed in this chapter.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping