ZFIN

ZFIN ID: ZDB-GENE-050301-2

ZFIN ID: ZDB-GENE-050301-2

CITATIONS (65 total)

Gene Name:	protein kinase containing Z-DNA binding domains
Gene Symbol:	pkz

Cao, L., Chang, M.X. (2025) Zebrafish CD44a variants suppress antiviral immunity through regulation of RIG-I ubiquitination and degradation. Fish & shellfish immunology. :110442110442

Fan, C., Ai, N., Ge, W., Wang, V.Y. (2025) Bcl3 Deficiency Leads to Hyperinflammation in Zebrafish. Cells. 14:

Wang, Y., Li, Z., Li, Z., Song, Y., Li, J., Yuan, L., Wang, C., Lai, F., Yan, R., Xiao, W., Wang, J. (2025) Zebrafish fkbp5 attenuates antiviral innate immunity by autophagic degradation of transcription factor irf7. Journal of immunology (Baltimore, Md. : 1950). :

Wang, Z., Chen, X., Zhu, C., Fan, S., Tang, J., Deng, H., Sun, X., Liu, X., Xiao, W. (2025) Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity. Proceedings of the National Academy of Sciences of the United States of America. 122:e2320644122e2320644122

Liu, X., Tang, J., Wang, Z., Zhu, C., Deng, H., Sun, X., Yu, G., Rong, F., Chen, X., Liao, Q., Jia, S., Liu, W., Zha, H., Fan, S., Cai, X., Gui, J.F., Xiao, W. (2024) Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3. Nature communications. 15:35333533

Qu, Z.L., Gong, X.Y., An, L.L., Sun, H.Y., Guo, W.H., Luan, H.Y., Wu, M.Y., Dan, C., Gui, J.F., Zhang, Y.B. (2024) Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity. iScience. 27:109497109497

Yu, G., Yuan, L., Li, X., Zuo, M., Wang, R., Chen, M., Liu, Y., Liu, X., Xiao, W. (2024) Zebrafish phd1 enhances mavs-mediated antiviral responses in a hydroxylation-independent manner. Journal of virology. 98(9):e0103824

Huang, L., Zhang, L., Huo, H.J., Hou, J., Niu, M.M., Nie, P., Chen, S.N. (2023) FTR33, a member of fish-specific TRIM (finTRIM) subfamily, regulates negatively type I IFN antiviral immunity in zebrafish. Developmental and comparative immunology. 142:104671104671

Ouyang, G., Liao, Q., Fan, S., Cai, X., Wang, J., Liu, X., Xiao, W. (2023) Zebrafish mavs Is Essential for Antiviral Innate Immunity. Journal of immunology (Baltimore, Md. : 1950). 210(9):1314-1323

Streiff, C., He, B., Morvan, L., Zhang, H., Delrez, N., Fourrier, M., Manfroid, I., Suárez, N.M., Betoulle, S., Davison, A.J., Donohoe, O., Vanderplasschen, A. (2023) Susceptibility and Permissivity of Zebrafish (Danio rerio) Larvae to Cypriniviruses. Viruses. 15(3):

Yu, G.Q., Chen, M.J., Wang, Y.J., Liu, Y.Q., Zuo, M.Z., Zhang, Z.H., Li, G.X., Liu, B.Z., Li, M. (2023) Zebrafish spop promotes ubiquitination and degradation of mavs to suppress antiviral response via the lysosomal pathway. International journal of biological macromolecules. 256(Pt 2):128451

Cai, X., Zhou, Z., Zhu, J., Liu, X., Ouyang, G., Wang, J., Li, Z., Li, X., Zha, H., Zhu, C., Rong, F., Tang, J., Liao, Q., Chen, X., Xiao, W. (2022) Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses. Cell Reports. 39:110920

Liao, Q., Ouyang, G., Zhu, J., Cai, X., Yu, G., Zhou, Z., Liu, X., Wang, J., Xiao, W. (2021) Zebrafish sirt7 Negatively Regulates Antiviral Responses by Attenuating Phosphorylation of irf3 and irf7 Independent of Its Enzymatic Activity. Journal of immunology (Baltimore, Md. : 1950). 207(12):3050-3059

Zhou, Z., Cai, X., Zhu, J., Li, Z., Yu, G., Liu, X., Ouyang, G., Xiao, W. (2021) Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7. Journal of immunology (Baltimore, Md. : 1950). 207(1):244-256

Zhu, L., Nie, L., Xie, S., Li, M., Zhu, C., Qiu, X., Kuang, J., Liu, C., Lu, C., Li, W., Meng, E., Zhang, D., Zhu, L. (2021) Attenuation of Antiviral Immune Response Caused by Perturbation of TRIM25-Mediated RIG-I Activation under Simulated Microgravity. Cell Reports. 34:108600

Li, Z., Fan, S., Wang, J., Chen, X., Liao, Q., Liu, X., Ouyang, G., Cao, H., Xiao, W. (2020) Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7. Journal of immunology (Baltimore, Md. : 1950). 205(7):1897-1908

Ouyang, G., Liao, Q., Zhang, D., Rong, F., Cai, X., Fan, S., Zhu, J., Wang, J., Liu, X., Liu, X., Xiao, W. (2020) Zebrafish NF-κB/p65 Is Required for Antiviral Responses. Journal of immunology (Baltimore, Md. : 1950). 204(11):3019-3029

Wu, X., Teame, T., Hao, Q., Ding, Q., Liu, H., Ran, C., Yang, Y., Zhang, Y., Zhou, Z., Duan, M., Zhang, Z. (2020) Use of a paraprobiotic and postbiotic feed supplement (HWF™) improves the growth performance, composition and function of gut microbiota in hybrid sturgeon (Acipenser baerii x Acipenser schrenckii). Fish & shellfish immunology. 104:36-45

Wu, X.M., Zhang, J., Li, P.W., Hu, Y.W., Cao, L., Ouyang, S., Bi, Y.H., Nie, P., Chang, M.X. (2020) NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS. Journal of immunology (Baltimore, Md. : 1950). 204(8):2216-2231

Xiong, F., Cao, L., Wu, X.M., Chang, M.X. (2020) The function of zebrafish gpbar1 in antiviral response and lipid metabolism. Developmental and comparative immunology. 116:103955

Yu, G., Li, X., Zhou, Z., Tang, J., Wang, J., Liu, X., Fan, S., Ouyang, G., Xiao, W. (2020) Zebrafish phd3 Negatively Regulates Antiviral Responses via Suppression of Irf7 Transactivity Independent of Its Prolyl Hydroxylase Activity. Journal of immunology (Baltimore, Md. : 1950). 205(4):1135-1146

Zhang, J., Wu, X.M., Hu, Y.W., Chang, M.X. (2020) A Novel Transcript Isoform of TBK1 Negatively Regulates Type I IFN Production by Promoting Proteasomal Degradation of TBK1 and Lysosomal Degradation of IRF3. Frontiers in immunology. 11:580864

Zhu, J., Liu, X., Cai, X., Ouyang, G., Fan, S., Wang, J., Xiao, W. (2020) Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid-inducible gene-I-like receptor signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:988-1000

Zhu, J., Liu, X., Cai, X., Ouyang, G., Zha, H., Zhou, Z., Liao, Q., Wang, J., Xiao, W. (2020) Zebrafish prmt3 negatively regulates antiviral responses. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(8):10212-10227

Gómez-Abenza, E., Ibáñez-Molero, S., García-Moreno, D., Fuentes, I., Zon, L.I., Mione, M.C., Cayuela, M.L., Gabellini, C., Mulero, V. (2019) Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment. Journal of experimental & clinical cancer research : CR. 38:405

Yu, G., Liu, X., Tang, J., Xu, C., Ouyang, G., Xiao, W. (2019) Neddylation Facilitates the Antiviral Response in Zebrafish. Frontiers in immunology. 10:1432

Hu, Y.W., Zhang, J., Wu, X.M., Cao, L., Nie, P., Chang, M.X. (2018) TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation. Frontiers in immunology. 9:84

Zhang, Y., Su, G., Li, M., Li, S., Wang, Q., Zhu, G., Letcher, R.J., Liu, C. (2018) Chemical and biological transfer: Which one is responsible for the maternal transfer toxicity of tris(1,3-dichloro-2-propyl) phosphate in zebrafish?. Environmental pollution (Barking, Essex : 1987). 243:1376-1382

Espín-Palazón, R., Martínez-López, A., Roca, F.J., López-Muñoz, A., Tyrkalska, S.D., Candel, S., García-Moreno, D., Falco, A., Meseguer, J., Estepa, A., Mulero, V. (2016) TNFα Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response. PLoS pathogens. 12:e1005699

Liu, X., Cai, X., Zhang, D., Xu, C., Xiao, W. (2016) Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7. Journal of immunology (Baltimore, Md. : 1950). 197(12):4736-4749

Subramani, V.K., Kim, D., Yun, K., Kim, K.K. (2016) Structural and functional studies of a large winged Z-DNA binding domain of Danio rerio protein kinase PKZ. FEBS letters. 590(14):2275-85

Zhang, L., Chen, W.Q., Hu, Y.W., Wu, X.M., Nie, P., Chang, M.X. (2016) TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway. Fish & shellfish immunology. 54:135-43

Chen, H.Y., Liu, W., Wu, S.Y., Chiou, P.P., Li, Y.H., Chen, Y.C., Lin, G.H., Lu, M.W., Wu, J.L. (2015) RIG-I specifically mediates group II type I IFN activation in nervous necrosis virus infected zebrafish cells. Fish & shellfish immunology. 43(2):427-35

Chen, W.Q., Hu, Y.W., Zou, P.F., Ren, S.S., Nie, P., Chang, M.X. (2015) MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. Developmental and comparative immunology. 49:19-30

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41

Nie, L., Xiong, R., Zhang, Y.S., Zhu, L.Y., Shao, J.Z., and Xiang, L.X. (2014) Conserved inhibitory role of teleost SOCS-1s in IFN signaling pathways. Developmental and comparative immunology. 43(1):23-29

de Rosa, M., Zacarias, S., and Athanasiadis, A. (2013) Structural basis for Z-DNA binding and stabilization by the zebrafish Z-DNA dependent protein kinase PKZ. Nucleic acids research. 41(21):9924-33

Liu, Z.Y., Jia, K.T., Li, C., Weng, S.P., Guo, C.J., and He, J.G. (2013) A truncated Danio rerio PKZ isoform functionally interacts with eIF2alpha and inhibits protein synthesis. Gene. 527(1):292-300

Xiong, R., Nie, L., Xiang, L.X., and Shao, J.Z. (2012) Characterization of a PIAS4 Homologue from Zebrafish: Insights into Its Conserved Negative Regulatory Mechanism in the TRIF, MAVS, and IFN Signaling Pathways during Vertebrate Evolution. Journal of immunology (Baltimore, Md. : 1950). 188(6):2653-2668

Rothenburg, S., Chinchar, V.G., and Dever, T.E. (2011) Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR. BMC microbiology. 11:56

Li, Z., Xu, X., Huang, L., Wu, J., Lu, Q., Xiang, Z., Liao, J., Weng, S., Yu, X., and He, J. (2010) Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish & shellfish immunology. 29(3):399-406

López-Muñoz, A., Roca, F.J., Sepulcre, M.P., Meseguer, J., and Mulero, V. (2010) Zebrafish Larvae Are Unable To Mount a Protective Antiviral Response Against Waterborne Infection by Spring Viremia of Carp Virus. Developmental and comparative immunology. 34(5):546-552

Zenke, K., Nam, Y.K., and Kim, K.H. (2010) Molecular cloning and expression analysis of double-stranded RNA-dependent protein kinase (PKR) in rock bream (Oplegnathus fasciatus). Veterinary Immunology and Immunopathology. 133(2-4):290-295

López-Muñoz, A., Roca, F.J., Meseguer, J., and Mulero, V. (2009) New insights into the evolution of IFNs: zebrafish Group II IFNs induce a rapid and transient expression of IFN-dependent genes and display powerful antiviral activities. Journal of immunology (Baltimore, Md. : 1950). 182(6):3440-3449

Rothenburg, S., Deigendesch, N., Dey, M., Dever, T.E., and Tazi, L. (2008) Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: Varying the number of double-stranded RNA binding domains and lineage-specific duplications. BMC Biology. 6:12

Perelygin, A.A., Lear, T.L., Zharkikh, A.A., and Brinton, M.A. (2006) Comparative analysis of vertebrate EIF2AK2 (PKR) genes and assignment of the equine gene to ECA15q24-q25 and the bovine gene to BTA11q12-q15. Genetics, selection, evolution : GSE. 38(5):551-563

Rothenburg, S., Deigendesch, N., Dittmar, K., Koch-Nolte, F., Haag, F., Lowenhaupt, K., and Rich, A. (2005) A PKR-like eukaryotic initiation factor 2{alpha} kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains. Proceedings of the National Academy of Sciences of the United States of America. 102(5):1602-1607

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (16):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.