Ao, J., Mu, Y., Wang, K., Sun, M., Wang, X., Chen, X. (2016) Identification and characterization of a novel Toll-like receptor 2 homologue in the large yellow croaker Larimichthys crocea. Fish & shellfish immunology. 48:221-7
|
Arias-Jayo, N., Abecia, L., Alonso-Sáez, L., Ramirez-Garcia, A., Rodriguez, A., Pardo, M.A. (2018) High-Fat Diet Consumption Induces Microbiota Dysbiosis and Intestinal Inflammation in Zebrafish. Microbial ecology. 76(4):1089-1101
|
Bian, W.P., Xie, S.L., Wang, C., Martinovich, G.G., Ma, Y.B., Jia, P.P., Pei, D.S. (2023) mitfa deficiency promotes immune vigor and potentiates antitumor effects in zebrafish. Fish & shellfish immunology. 142:109130
|
Chai, T., Cui, F., Song, Y., Ye, L., Li, T., Qiu, J., Liu, X. (2018) Enantioselective Toxicity in Adult Zebrafish (Danio rerio) Induced by Chiral PCB91 through Multiple Pathways. Environmental science & technology. 52(9):5448-5458
|
|
|
|
|
Chang, M.Y., Cheng, Y.C., Hsu, S.H., Ma, T.L., Chou, L.F., Hsu, H.H., Tian, Y.C., Chen, Y.C., Sun, Y.J., Hung, C.C., Pan, R.L., Yang, C.W. (2016) Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae. Scientific Reports. 6:27838
|
Chen, Q., Wei, T., Yang, B., Li, S., Ge, L., Zhou, A., Xie, S. (2022) The Impact of Deleting the mitfa gene in Zebrafish on the Intestinal Microbiota Community. Gene. 846:146870
|
Chen, R.J., Huang, C.C., Pranata, R., Lee, Y.H., Chen, Y.Y., Wu, Y.H., Wang, Y.J. (2021) Modulation of Innate Immune Toxicity by Silver Nanoparticle Exposure and the Preventive Effects of Pterostilbene. International Journal of Molecular Sciences. 22(5):
|
|
|
Contreras, M., Pacheco, I., Alberdi, P., Díaz-Sánchez, S., Artigas-Jerónimo, S., Mateos-Hernández, L., Villar, M., Cabezas-Cruz, A., de la Fuente, J. (2020) Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model. Frontiers in cellular and infection microbiology. 10:78
|
Deng, Z., Hou, K., Valencak, T.G., Luo, X.M., Liu, J., Wang, H. (2022) AI-2/LuxS Quorum Sensing System Promotes Biofilm Formation of Lactobacillus rhamnosus GG and Enhances the Resistance to Enterotoxigenic Escherichia coli in Germ-Free Zebrafish. Microbiology spectrum. 10(4):e0061022
|
|
|
Dong, X., Zhang, Z., Meng, S., Pan, C., Yang, M., Wu, X., Yang, L., Xu, H. (2018) Parental exposure to bisphenol A and its analogs influences zebrafish offspring immunity. The Science of the total environment. 610-611:291-297
|
Edirisinghe, S.L., Dananjaya, S.H.S., Nikapitiya, C., Liyanage, T.D., Lee, K.A., Oh, C., Kang, D.H., De Zoysa, M. (2019) Novel pectin isolated from Spirulina maxima enhances the disease resistance and immune responses in zebrafish against Edwardsiella piscicida and Aeromonas hydrophila. Fish & shellfish immunology. 94:558-565
|
Fan, Y., Zhou, Y., Zeng, L., Jiang, N., Liu, W., Zhao, J., Zhong, Q. (2017) Identification, structural characterization, and expression analysis of toll-like receptors 2 and 3 from gibel carp (Carassius auratus gibelio). Fish & shellfish immunology. 72:629-638
|
|
|
Gao, Y., Wu, H., Wang, Q., Qu, J., Liu, Q., Xiao, J., Zhang, Y. (2014) A live attenuated combination vaccine evokes effective immune-mediated protection against Edwardsiella tarda and Vibrio anguillarum. Vaccine. 32(45):5937-44
|
|
|
Gu, W., Liu, S., Chen, L., Liu, Y., Gu, C., Ren, H.Q., Wu, B. (2020) Single-cell RNA sequencing reveals size-dependent effects of polystyrene microplastics on immune and secretory cell populations from zebrafish intestines. Environmental science & technology. 54(6):3417-3427
|
|
|
He, M., Halima, M., Xie, Y., Schaaf, M.J.M., Meijer, A.H., Wang, M. (2020) Ginsenoside Rg1 Acts as a Selective Glucocorticoid Receptor Agonist with Anti-Inflammatory Action without Affecting Tissue Regeneration in Zebrafish Larvae. Cells. 9(5):
|
|
|
Hu, W., Liu, L., Forn-Cuní, G., Ding, Y., Alia, A., Spaink, H.P. (2023) Transcriptomic and Metabolomic Studies Reveal That Toll-like Receptor 2 Has a Role in Glucose-Related Metabolism in Unchallenged Zebrafish Larvae (Danio rerio). Biology. 12(2):
|
Hu, W., van Steijn, L., Li, C., Verbeek, F.J., Cao, L., Merks, R.M.H., Spaink, H.P. (2021) A Novel Function of TLR2 and MyD88 in the Regulation of Leukocyte Cell Migration Behavior During Wounding in Zebrafish Larvae. Frontiers in cell and developmental biology. 9:624571
|
Hu, W., Yang, S., Shimada, Y., Münch, M., Marín-Juez, R., Meijer, A.H., Spaink, H.P. (2019) Infection and RNA-seq analysis of a zebrafish tlr2 mutant shows a broad function of this toll-like receptor in transcriptional and metabolic control and defense to Mycobacterium marinum infection. BMC Genomics. 20:878
|
|
|
|
|
|
|
Liang, H., Li, M., Chen, J., Zhou, W., Xia, D., Ding, Q., Yang, Y., Zhang, Z., Ran, C., Zhou, Z. (2024) The intestinal microbiome and Cetobacterium somerae inhibit viral infection through TLR2-type I IFN signaling axis in zebrafish. Microbiome. 12:244244
|
Lin, W., Guo, H., Wang, L., Zhang, D., Wu, X., Li, L., Qiu, Y., Yang, L., Li, D., Tang, R. (2019) Parental transfer of microcystin-LR induced innate immune dysfunction of zebrafish: A cross-generational study. Environmental science & technology. 54(2):1014-1023
|
Lin, W., Guo, H., Wang, L., Zhang, D., Wu, X., Li, L., Qiu, Y., Yang, L., Li, D., Tang, R. (2019) Waterborne microcystin-LR exposure induced chronic inflammatory response via MyD88-dependent toll-like receptor signaling pathway in male zebrafish. The Science of the total environment. 702:134969
|
Liu, J., Wei, T., Wu, X., Zhong, H., Qiu, W., Zheng, Y. (2019) Early exposure to environmental levels of sulfamethoxazole triggers immune and inflammatory response of healthy zebrafish larvae. The Science of the total environment. 703:134724
|
Liu, X., Wu, H., Chang, X., Tang, Y., Liu, Q., Zhang, Y. (2014) Notable mucosal immune responses induced in the intestine of zebrafish (Danio rerio) bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish & shellfish immunology. 40(1):99-108
|
Liyanage, T.D., Dahanayake, P.S., Edirisinghe, S.L., Nikapitiya, C., Heo, G.J., De Zoysa, M., Whang, I. (2020) Biological Activity of Porcine Gastric Mucin on Stress Resistance and Immunomodulation. Molecules. 25(13):
|
Ma, K., Chen, S., Wu, Y., Ma, Y., Qiao, H., Fan, J., Wu, H. (2022) Dietary supplementation with microalgae enhances the zebrafish growth performance by modulating immune status and gut microbiota. Applied Microbiology and Biotechnology. 106(2):773-788
|
|
|
Meijer, A.H., Gabby Krens, S.F., Medina Rodriguez, I.A., He, S., Bitter, W., Snaar-Jagalska, Ewa B., and Spaink, H.P. (2004) Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish. Molecular immunology. 40(11):773-783
|
Novoa, B., Romero, A., Mulero, V., Rodriguez, I., Fernandez, I., and Figueras, A. (2006) Zebrafish (Danio rerio) as a model for the study of vaccination against viral haemorrhagic septicemia virus (VHSV). Vaccine. 24(31-31):5806-5816
|
Pacheco, I., Contreras, M., Villar, M., Risalde, M.A., Alberdi, P., Cabezas-Cruz, A., Gortázar, C., de la Fuente, J. (2020) Vaccination with Alpha-Gal Protects Against Mycobacterial Infection in the Zebrafish Model of Tuberculosis. Vaccines. 8(2):
|
Pacheco, I., Díaz-Sánchez, S., Contreras, M., Villar, M., Cabezas-Cruz, A., Gortázar, C., de la Fuente, J. (2021) Probiotic Bacteria with High Alpha-Gal Content Protect Zebrafish against Mycobacteriosis. Pharmaceuticals (Basel, Switzerland). 14(7):
|
Pan, C.Y., Wu, J.L., Hui, C.F., Lin, C.H., and Chen, J.Y. (2011) Insights into the antibacterial and immunomodulatory functions of the antimicrobial peptide, epinecidin-1, against Vibrio vulnificus infection in zebrafish. Fish & shellfish immunology. 31(6):1019-25
|
|
|
Pietretti, D., Scheer, M., Fink, I.R., Taverne, N., Savelkoul, H.F., Spaink, H.P., Forlenza, M., and Wiegertjes, G.F. (2014) Identification and functional characterization of nonmammalian Toll-like receptor 20. Immunogenetics. 66(2):123-141
|
|
|
Qin, C., Zhang, Z., Wang, Y., Li, S., Ran, C., Hu, J., Xie, Y., Li, W., Zhou, Z. (2017) EPSP of L. casei BL23 Protected against the Infection Caused by Aeromonas veronii via Enhancement of Immune Response in Zebrafish.. Frontiers in microbiology. 8:2406
|
Rajapaksha, D.C., Edirisinghe, S.L., Nikapitiya, C., Dananjaya, S., Kwun, H.J., Kim, C.H., Oh, C., Kang, D.H., De Zoysa, M. (2020) Spirulina maxima Derived Pectin Nanoparticles Enhance the Immunomodulation, Stress Tolerance, and Wound Healing in Zebrafish. Marine drugs. 18(11):
|
Sanchez-Gonzalez, R., Koupourtidou, C., Lepko, T., Zambusi, A., Novoselc, K.T., Durovic, T., Aschenbroich, S., Schwarz, V., Breunig, C.T., Straka, H., Huttner, H.B., Irmler, M., Beckers, J., Wurst, W., Zwergal, A., Schauer, T., Straub, T., Czopka, T., Trümbach, D., Götz, M., Stricker, S.H., Ninkovic, J. (2022) Innate Immune Pathways Promote Oligodendrocyte Progenitor Cell Recruitment to the Injury Site in Adult Zebrafish Brain. Cells. 11(3):
|
Shan, S., Liu, R., Feng, H., Meng, F., Aizaz, M., Yang, G. (2021) Identification and functional characterization of a fish-specific tlr19 in common carp (Cyprinus carpio L.) that recruits TRIF as an adaptor and induces ifn expression during the immune response. Veterinary research. 52:88
|
Shin, S., Kulatunga, D.C.M., Dananjaya, S.H.S., Nikapitiya, C., Lee, J., De Zoysa, M. (2017) Saprolegnia parasitica Isolated from Rainbow Trout in Korea: Characterization, Anti-Saprolegnia Activity and Host Pathogen Interaction in Zebrafish Disease Model.. Mycobiology. 45:297-311
|
Singer, R., Oganezova, I., Hu, W., Liu, L., Ding, Y., de Groot, H.J.M., Spaink, H.P., Alia, A. (2024) Ultrahigh field diffusion magnetic resonance imaging uncovers intriguing microstructural changes in the adult zebrafish brain caused by Toll-like receptor 2 genomic deletion. NMR in Biomedicine. 37(10):e5170
|
|
|
Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
|
Sun, Z., Shen, B., Wu, H., Zhou, X., Wang, Q., Xiao, J., Zhang, Y. (2015) The secreted fructose 1,6-bisphosphate aldolase as a broad spectrum vaccine candidate against pathogenic bacteria in aquaculture. Fish & shellfish immunology. 46(2):638-47
|
Tang, H.P., Huang, C., Hu, C.B., Li, H., Shao, T., Ji, J.F., Bai, J., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2021) Inhibitory Role of an Aeromonas hydrophila TIR Domain Effector in Antibacterial Immunity by Targeting TLR Signaling Complexes in Zebrafish. Frontiers in microbiology. 12:694081
|
|
|
Tyrkalska, S.D., Martínez-López, A., Pedoto, A., Candel, S., Cayuela, M.L., Mulero, V. (2022) The Spike protein of SARS-CoV-2 signals via Tlr2 in zebrafish. Developmental and comparative immunology. 140:104626
|
van den Bos, R., Cromwijk, S., Tschigg, K., Althuizen, J., Zethof, J., Whelan, R., Flik, G., Schaaf, M. (2020) Early Life Glucocorticoid Exposure Modulates Immune Function in Zebrafish (Danio rerio) Larvae. Frontiers in immunology. 11:727
|
van der Sar, A.M., Stockhammer, O.W., van der Laan, C., Spaink, H.P., Bitter, W., and Meijer, A.H. (2006) MyD88 Innate Immune Function in a Zebrafish Embryo Infection Model. Infection and Immunity. 74(4):2436-2441
|
Vaz-Rodrigues, R., Mazuecos, L., Contreras, M., González-García, A., Rafael, M., Villar, M., de la Fuente, J. (2025) Tick salivary proteins metalloprotease and allergen-like p23 are associated with response to glycan α-Gal and mycobacterium infection. Scientific Reports. 15:88498849
|
Wang, C., Chen, Y.L., Bian, W.P., Xie, S.L., Qi, G.L., Liu, L., Strauss, P.R., Zou, J.X., Pei, D.S. (2017) Deletion of mstna and mstnb impairs the immune system and affects growth performance in zebrafish. Fish & shellfish immunology. 72:572-580
|
Wasana, W.P., Senevirathne, A., Nikapitiya, C., Eom, T.Y., Lee, Y., Lee, J.S., Kang, D.H., Oh, C., De Zoysa, M. (2021) A Novel Pseudoalteromonas xiamenensis Marine Isolate as a Potential Probiotic: Anti-Inflammatory and Innate Immune Modulatory Effects against Thermal and Pathogenic Stresses. Marine drugs. 19(12):
|
Xin, G., Li, W.G., Yoganandham, S.T., Jia, P.P., Ma, Y.B., Pei, D.S. (2020) Gut bacteria Vibrio sp. and Aeromonas sp. trigger the expression levels of proinflammatory cytokine: First evidence from the germ-free zebrafish. Fish & shellfish immunology. 106:518-525
|
|
|
Yang, D., Liu, Q., Ni, C., Li, S., Wu, H., Wang, Q., Xiao, J., and Zhang, Y. (2013) Gene expression profiling in live attenuated Edwardsiella tarda vaccine immunized and challenged zebrafish: Insights into the basic mechanisms of protection seen in immunized fish. Developmental and comparative immunology. 40(2):132-41
|
|
|
Yeh, D.W., Liu, Y.L., Lo, Y.C., Yuh, C.H., Yu, G.Y., Lo, J.F., Luo, Y., Xiang, R., and Chuang, T.H. (2013) Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 110(51):20711-20716
|
Zhang, C., Zhao, Z., Jia, Y.J., Zhang, P.Q., Sun, Y., Zhou, Y.C., Wang, G.X., Zhu, B. (2023) Rationally Designed Self-Assembling Nanovaccines Elicit Robust Mucosal and Systemic Immunity against Rhabdovirus. ACS applied materials & interfaces. 16(1):228-244
|
Zhang, H., Fang, W., Wang, D., Gao, N., Ding, Y., Chen, C. (2014) The role of interleukin family in perfluorooctanoic acid (PFOA)-induced immunotoxicity. Journal of hazardous materials. 280C:552-560
|
Zhang, Z., Ran, C., Ding, Q.W., Liu, H.L., Xie, M.X., Yang, Y.L., Xie, Y.D., Gao, C.C., Zhang, H.L., Zhou, Z.G. (2019) Ability of prebiotic polysaccharides to activate a HIF1α-antimicrobial peptide axis determines liver injury risk in zebrafish. Communications biology. 2:274
|
Zhang, Z., Zhang, H.L., Yang, D.H., Hao, Q., Yang, H.W., Meng, D.L., Meindert de Vos, W., Guan, L.L., Liu, S.B., Teame, T., Gao, C.C., Ran, C., Yang, Y.L., Yao, Y.Y., Ding, Q.W., Zhou, Z.G. (2024) Lactobacillus rhamnosus GG triggers intestinal epithelium injury in zebrafish revealing host dependent beneficial effects. iMeta. 3:e181e181
|
Zhong, Y., Shen, L., Ye, X., Zhou, D., He, Y., Zhang, H. (2020) Mechanism of immunosuppression in zebrafish (Danio rerio) spleen induced by environmentally relevant concentrations of perfluorooctanoic acid. Chemosphere. 249:126200
|
