Gene
tlr2
- ID
- ZDB-GENE-040219-6
- Name
- toll-like receptor 2
- Symbol
- tlr2 Nomenclature History
- Previous Names
-
- TIR2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity and triacyl lipopeptide binding activity. Acts upstream of or within several processes, including inflammatory response to wounding; regulation of glucose metabolic process; and regulation of leukocyte migration. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in brain; integument; intestine; liver; and spleen. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu520 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Hu et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | {Colorectal cancer, susceptibility to} | 114500 |
| {Leprosy, susceptibility to} | 246300 | ||
| {Mycobacterium tuberculosis, susceptibility to} | 607948 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000157 | Toll/interleukin-1 receptor homology (TIR) domain |
| Family | IPR017241 | Toll-like receptor |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR035897 | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily | Toll-like receptor |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6TS42 | InterPro | 788 | ||||||
| UniProtKB:F1QWS9 | InterPro | 818 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available