ZFIN

ZFIN ID: ZDB-GENE-021223-2

ZFIN ID: ZDB-GENE-021223-2

CITATIONS (69 total)

Gene Name:	melanocortin 4 receptor
Gene Symbol:	mc4r

Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201

Navarro, S., Crespo, D., Schulz, R.W., Ge, W., Rotllant, J., Cerdá-Reverter, J.M., Rocha, A. (2022) Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish. Animals : an open access journal from MDPI. 12(20):

Nipu, N., Antomagesh, F., Faught, E., Vijayan, M.M. (2022) Glucocorticoid receptor activation reduces food intake independent of hyperglycemia in zebrafish. Scientific Reports. 12:15677

Xu, J., Wang, M., Fu, Y., Zhang, C., Kuang, Z., Bian, S., Wan, R., Qu, S., Zhang, C. (2022) Reversion of MRAP2 Protein Sequence Generates a Functional Novel Pharmacological Modulator for MC4R Signaling. Biology. 11(6)

Del Vecchio, G., Murashita, K., Verri, T., Gomes, A.S., Rønnestad, I. (2021) Leptin receptor-deficient (knockout) zebrafish: effects on nutrient acquisition. General and comparative endocrinology. 310:113832

Li, Z., Jiang, B., Cao, B., Zhang, Z., Zhang, J., Li, J., Huang, Y., Wang, Y. (2021) Characterization of Four Orphan Receptors (GPR3, GPR6, GPR12 and GPR12L) in Chickens and Ducks and Regulation of GPR12 Expression in Ovarian Granulosa Cells by Progesterone. Genes. 12(4):

Schneider, A.C.R., de Moura, A.C., Carvalho, F.B., Alves, T., Meurer, F., Porawski, M., da Silveira, T.R. (2021) Effect of Melatonin on the Reduction of Hepatic Steatosis and Intestinal Leptin Expression in Zebrafish Exposed to Fructose. Zebrafish. 18(3):184-189

Fei, F., Sun, S., Li, Q., Pei, Z., Wang, L., Zhang, R., Luo, F., Yu, M., Wang, X. (2020) Combinatorial normalization of liver-derived cytokine pathways alleviates hepatic tumor-associated cachexia in zebrafish. Cancer research. 81(4):873-884

Reinoß, P., Ciglieri, E., Minére, M., Bremser, S., Klein, A., Löhr, H., Fuller, P.M., Büschges, A., Kloppenburg, P., Fenselau, H., Hammerschmidt, M. (2020) Hypothalamic Pomc Neurons Innervate the Spinal Cord and Modulate the Excitability of Premotor Circuits. Current biology : CB. 30(23):4579-4593.e7

Ahi, E.P., Brunel, M., Tsakoumis, E., Schmitz, M. (2019) Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Scientific Reports. 9:20166

London, S., Volkoff, H. (2019) Effects of fasting on the central expression of appetite-regulating and reproductive hormones in wild-type and Casper zebrafish (Danio rerio). General and comparative endocrinology. 282:113207

Shainer, I., Michel, M., Marquart, G.D., Bhandiwad, A.A., Zmora, N., Ben-Moshe Livne, Z., Zohar, Y., Hazak, A., Mazon, Y., Förster, D., Hollander-Cohen, L., Cone, R.D., Burgess, H.A., Gothilf, Y. (2019) Agouti-Related Protein 2 Is a New Player in the Teleost Stress Response System. Current biology : CB. 29(12):2009-2019.e7

Tu, W., Mart Iacute Nez L Oacute Pez, R.E.N.F., Navarro-Martin, L., Kostyniuk, D.J., Hum, C., Huang, J., Deng, M., Jin, Y., Chan, H.M., Mennigen, J. (2019) Bioconcentration and metabolic effects of emerging PFOS alternatives in developing zebrafish. Environmental science & technology. 53(22):13427-13439

Wang, M., Chen, Y., Zhu, M., Xu, B., Guo, W., Lyu, Y., Zhang, C. (2019) Pharmacological modulation of melanocortin-4 receptor by melanocortin receptor accessory protein 2 in Nile tilapia. General and comparative endocrinology. 282:113219

Forner-Piquer, I., Santangeli, S., Maradonna, F., Verde, R., Piscitelli, F., di Marzo, V., Habibi, H.R., Carnevali, O. (2018) Role of Bisphenol A on the Endocannabinoid System at central and peripheral levels: Effects on adult female zebrafish. Chemosphere. 205:118-125

Cortés, R., Teles, M., Oliveira, M., Fierro-Castro, C., Tort, L., Cerdá-Reverter, J.M. (2017) Effects of acute handling stress on short-term central expression of orexigenic/anorexigenic genes in zebrafish. Fish physiology and biochemistry. 44(1):257-272

den Broeder, M.J., Moester, M.J.B., Kamstra, J.H., Cenijn, P.H., Davidoiu, V., Kamminga, L.M., Ariese, F., de Boer, J.F., Legler, J. (2017) Altered Adipogenesis in Zebrafish Larvae Following High Fat Diet and Chemical Exposure Is Visualised by Stimulated Raman Scattering Microscopy. International Journal of Molecular Sciences. 18(4)

Fei, F., Sun, S.Y., Yao, Y.X., Wang, X. (2017) [Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r]. Sheng li xue bao : [Acta physiologica Sinica]. 69:61-69

Forner-Piquer, I., Maradonna, F., Gioacchini, G., Santangeli, S., Allarà, M., Piscitelli, F., Habibi, H.R., Di Marzo, V., Carnevali, O. (2017) Dose - specific effects of Di-isononyl phthalate on the endocannabinoid system and on liver of female zebrafish. Endocrinology. 158(10):3462-3476

Shainer, I., Buchshtab, A., Hawkins, T.A., Wilson, S.W., Cone, R.D., Gothilf, Y. (2017) Novel hypophysiotropic AgRP2 neurons and pineal cells revealed by BAC transgenesis in zebrafish. Scientific Reports. 7:44777

Falcinelli, S., Rodiles, A., Unniappan, S., Picchietti, S., Gioacchini, G., Merrifield, D.L., Carnevali, O. (2016) Probiotic treatment reduces appetite and glucose level in the zebrafish model. Scientific Reports. 6:18061

Guillot, R., Cortés, R., Navarro, S., Mischitelli, M., García-Herranz, V., Sánchez, E., Cal, L., Navarro, J.C., Míguez, J., Afanasyev, S., Krasnov, A., Cone, R.D., Rotllant, J., Cerdá-Reverter, J.M. (2016) Behind melanocortin antagonist overexpression in the zebrafish brain: A behavioral and transcriptomic approach. Hormones and behavior. 82:87-100

Martella, A., Silvestri, C., Maradonna, F., Gioacchini, G., Allarà, M., Radaelli, G., Overby, D.R., Di Marzo, V., Carnevali, O. (2016) Bisphenol A induces fatty liver by an endocannabinoid-mediated positive feedback loop. Endocrinology. 157(5):1751-63

O'Hare, E.A., Yerges-Armstrong, L.M., Perry, J.A., Shuldiner, A.R., Zaghloul, N.A. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Molecular endocrinology (Baltimore, Md.). 30(4):429-45

Xie, S.L., Bian, W.P., Wang, C., Junaid, M., Zou, J.X., Pei, D.S. (2016) A novel technique based on in vitro oocyte injection to improve CRISPR/Cas9 gene editing in zebrafish. Scientific Reports. 6:34555

Wang, H., Semenova, S., Kuusela, S., Panula, P., Lehtonen, S. (2015) Tankyrases regulate glucoregulatory mechanisms and somatic growth via the central melanocortin system in zebrafish larvae. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(11):4435-48

Josep Agulleiro, M., Cortés, R., Fernández-Durán, B., Navarro, S., Guillot, R., Meimaridou, E., Clark, A.J., and Cerdá-Reverter, J.M. (2013) Melanocortin 4 Receptor Becomes an ACTH Receptor by Coexpression of Melanocortin Receptor Accessory Protein 2. Molecular endocrinology (Baltimore, Md.). 27(11):1934-1945

Piccinetti, C.C., Migliarini, B., Olivotto, I., Simoniello, M.P., Giorgini, E., and Carnevali, O. (2013) Melatonin and Peripheral Circuitries: Insights on Appetite and Metabolism in Danio Rerio. Zebrafish. 10(3):275-82

Renquist, B.J., Zhang, C., Williams, S.Y., and Cone, R.D. (2013) Development of an Assay for High-Throughput Energy Expenditure Monitoring in the Zebrafish. Zebrafish. 10(3):343-52

Sebag, J.A., Zhang, C., Hinkle, P.M., Bradshaw, A.M., and Cone, R.D. (2013) Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish. Science (New York, N.Y.). 341(6143):278-281

Gupta, A., Christensen, R.G., Rayla, A.L., Lakshmanan, A., Stormo, G.D., and Wolfe, S.A. (2012) An optimized two-finger archive for ZFN-mediated gene targeting. Nature Methods. 9(6):588-590

Shimada, Y., Hirano, M., Nishimura, Y., and Tanaka, T. (2012) A high-throughput fluorescence-based assay system for appetite-regulating gene and drug screening. PLoS One. 7(12):e52549

Zhang, C., Forlano, P.M., and Cone, R.D. (2012) AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost. Cell Metabolism. 15(2):256-264

Kumar, A., Bhandari, A., Sinha, R., Goyal, P., and Grapputo, A. (2011) Spliceosomal Intron Insertions in Genome Compacted Ray-Finned Fishes as Evident from Phylogeny of MC Receptors, Also Supported by a Few Other GPCRs. PLoS One. 6(8):e22046

Piccinetti, C.C., Migliarini, B., Olivotto, I., Coletti, G., Amici, A., and Carnevali, O. (2010) Appetite regulation: The central role of melatonin in Danio rerio. Hormones and behavior. 58(5):780-785

Zhang, C., Song, Y., Thompson, D.A., Madonna, M.A., Millhauser, G.L., Toro, S., Varga, Z., Westerfield, M., Gamse, J., Chen, W., Cone, R.D. (2010) Pineal-specific agouti protein regulates teleost background adaptation. Proceedings of the National Academy of Sciences of the United States of America. 107(47):20164-71

Sánchez, E., Rubio, V.C., Thompson, D.A., Metz, J., Flik, G., Millhauser, G.L., and Cerda-Reverter, J.M. (2009) Phosphodiesterase inhibitor-dependent inverse agonism of agouti-related protein on melanocortin 4 receptor in sea bass (Dicentrarchus labrax). American journal of physiology. Regulatory, integrative and comparative physiology. 296(5):R1293-R1306

Kobayashi, Y., Tsuchiya, K., Yamanome, T., Schiöth, H.B., Kawauchi, H., and Takahashi, A. (2008) Food deprivation increases the expression of melanocortin-4 receptor in the liver of barfin flounder, Verasper moseri. General and comparative endocrinology. 155(2):280-287

Haitina, T., Klovins, J., Takahashi, A., Löwgren, M., Ringholm, A., Enberg, J., Kawauchi, H., Larson, E.T., Fredriksson, R., and Schiöth, H.B. (2007) Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes. BMC Evolutionary Biology. 7:101

Selz, Y., Braasch, I., Hoffmann, C., Schmidt, C., Schultheis, C., Schartl, M., and Volff, J.N. (2007) Evolution of melanocortin receptors in teleost fish: The melanocortin type 1 receptor. Gene. 401(1-2):114-122

Song, Y., Cone, R.D. (2007) Creation of a genetic model of obesity in a teleost. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 21:2042-9

Logan, D.W., Bryson-Richardson, R.J., Pagan, K.E., Taylor, M.S., Currie, P.D., and Jackson, I.J. (2003) The structure and evolution of the melanocortin and MCH receptors in fish and mammals. Genomics. 81(2):184-191

Logan, D.W., Bryson-Richardson, R.J., Taylor, M.S., Currie, P., and Jackson, I.J. (2003) Sequence characterization of teleost fish melanocortin receptors. Annals of the New York Academy of Sciences. 994:319-330

Schiöth, H.B., Lagerström, M.C., Watanobe, H., Jonsson, L., Vergoni, A.V., Ringholm, A., Skarphedinsson, J.O., Skuladottir, G.V., Klovins, J., and Fredriksson, R. (2003) Functional role, structure, and evolution of the melanocortin-4 receptor. Annals of the New York Academy of Sciences. 994:74-83

Ringholm, A., Fredriksson, R., Poliakova, N., Yan, Y.-L., Postlethwait, J.H., Larhammar, D., and Schiöth, H.B. (2002) One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology. Journal of neurochemistry. 82(1):6-18

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (23):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Busch-Nentwich, E., Kettleborough, R., Harvey, S., Collins, J., Ding, M., Dooley, C., Fenyes, F., Gibbons, R., Herd, C., Mehroke, S., Scahill, C., Sealy, I., Wali, N., White, R., and Stemple, D.L. (2012) Sanger Institute Zebrafish Mutation Project mutant, phenotype and image data submission. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. Manually curated data.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

ZIRC and ZFIN staff (2011) Mutant and Transgenic Line Submissions 2011. ZFIN Direct Data Submission.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA curators, UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. Manually curated data.

ZF-MODELS Consortium (2007) ZF-MODELS Consortium and Zebrafish Mutation Resource targeted knock-out mutants. ZFIN Direct Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.