Gene

mc4r

ID
ZDB-GENE-021223-2
Name
melanocortin 4 receptor
Symbol
mc4r Nomenclature History
Previous Names
  • zMC4
  • si:dkey-151m6.62
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Exhibits melanocortin receptor activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; energy homeostasis; and negative regulation of feeding behavior. Predicted to localize to cytoplasm and plasma membrane. Is expressed in brain and myotome. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor).
Genome Resources
Note
None
Expression
All Expression Data
17 figures from 12 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mc4r Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Obesity (BMIQ20) 618406
{Obesity, resistance to (BMIQ20)} 618406
Associated With mc4r Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000155 Melanocortin 4 receptor
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR001671 Melanocortin/ACTH receptor
Family IPR001908 Melanocortin receptor
Domain Details Per Protein
Protein Length GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like Melanocortin 4 receptor Melanocortin/ACTH receptor Melanocortin receptor
UniProtKB:B0V1P1 326
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations