ZFIN

ZFIN ID: ZDB-GENE-021119-2

ZFIN ID: ZDB-GENE-021119-2

CITATIONS (74 total)

Gene Name:	dopamine receptor D2a
Gene Symbol:	drd2a

Baker, C.E., Marta, A.G., Zimmerman, N.D., Korade, Z., Mathy, N.W., Wilton, D., Simeone, T., Kochvar, A., Kramer, K.L., Stessman, H.A.F., Shibata, A. (2024) CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression. Biomolecules. 14(8):

Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576

Brown-Panton, C.A., Sabour, S., Zoidl, G.S.O., Zoidl, C., Tabatabaei, N., Zoidl, G.R. (2023) Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish. Frontiers in cell and developmental biology. 11:11502731150273

Moraes, I.B., Paiva, I.M., Moreira-Júnior, R.E., Sartori, B.M., Franco, R.R., Espindola, F.S., Murgas, L.D.S., Brunialti-Godard, A.L. (2023) Ethanol Preference Leads to Alterations in Telomere Length, Mitochondria Copy Number, and Antioxidant Enzyme Activity in Zebrafish Brains. Frontiers in bioscience (Landmark edition). 28:7373

Simonian, R., Pannia, E., Hammoud, R., Noche, R.R., Cui, X., Kranenburg, E., Kubant, R., Ashcraft, P., Wasek, B., Bottiglieri, T., Dowling, J.J., Anderson, G.H. (2023) Methylenetetrahydrofolate reductase deficiency and high dose FA supplementation disrupt embryonic development of energy balance and metabolic homeostasis in zebrafish. Human molecular genetics. 32(9):1575-1588

Thiagarajan, S.K., Mok, S.Y., Ogawa, S., Parhar, I.S., Tang, P.Y. (2023) Integrative Roles of Dopamine Pathway and Calcium Channels Reveal a Link between Schizophrenia and Opioid Use Disorder. International Journal of Molecular Sciences. 24(4):

Yang, R., Zhang, Y., Deng, Y., Yang, Y., Zhong, W., Zhu, L. (2023) 2-Ethylhexyl Diphenyl Phosphate Causes Obesity in Zebrafish by Stimulating Overeating via Inhibition of Dopamine Receptor D2. Environmental science & technology. 57(38):14162-14172

Dongjie, S., Rajendran, R.S., Xia, Q., She, G., Tu, P., Zhang, Y., Liu, K. (2022) Neuroprotective effects of Tongtian oral liquid, a Traditional Chinese Medicine in the Parkinson's disease-induced zebrafish model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 148:112706

Hosseini, P., Mirsadeghi, S., Rahmani, S., Izadi, A., Rezaei, M., Ghodsi, Z., Rahimi-Movaghar, V., Kiani, S. (2022) Dopamine Receptors Gene Expression Pattern and Locomotor Improvement Differ Between Female and Male Zebrafish During Spinal Cord Auto Repair. Zebrafish. 19(4):137-147

Huang, W., Xiao, J., Shi, X., Zheng, S., Li, H., Liu, C., Wu, K. (2022) Effects of di-(2-ethylhexyl) phthalate (DEHP) on behavior and dopamine signaling in zebrafish (Danio rerio). Environmental Toxicology and Pharmacology. 93:103885

Leggieri, A., García-González, J., Torres-Perez, J.V., Havelange, W., Hosseinian, S., Mech, A.M., Keatinge, M., Busch-Nentwich, E.M., Brennan, C.H. (2022) Ankk1 Loss of Function Disrupts Dopaminergic Pathways in Zebrafish. Frontiers in neuroscience. 16:794653

Shi, Z., Liang, X., Zhao, Y., Liu, W., Martyniuk, C.J. (2022) Neurotoxic effects of synthetic phenolic antioxidants on dopaminergic, serotoninergic, and GABAergic signaling in larval zebrafish (Danio rerio). The Science of the total environment. 830:154688

Varela, T., Varela, D., Martins, G., Conceição, N., Cancela, M.L. (2022) Cdkl5 mutant zebrafish shows skeletal and neuronal alterations mimicking human CDKL5 deficiency disorder. Scientific Reports. 12:9325

Zhou, J., Peng, C., Li, Q., Yan, X., Yang, L., Li, M., Cao, X., Xie, X., Chen, D., Rao, C., Huang, S., Peng, F., Pan, X. (2022) Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells. Frontiers in pharmacology. 13:837810

Zhu, H., Zhang, X., Xu, S., Wu, J., Hou, M., Zhao, H., Zhou, Q., Zhong, X. (2022) Gene duplication, conservation, and divergence of activating transcription factor 5 gene in zebrafish. Journal of experimental zoology. Part B, Molecular and developmental evolution. 338(5):301-313

Chen, Z., Zhijie, C., Yuting, Z., Chan, L., Shilin, X., Qichun, Z., Jinying, O., Jing, L., Chaohua, L., Zhixian, M. (2021) The Ameliorative Effects of Isorhynchophylline on Morphine Dependence Are Mediated Through the Microbiota-Gut-Brain Axis. Frontiers in pharmacology. 12:526923

Cleal, M., Fontana, B.D., Double, M., Mezabrovschi, R., Parcell, L., Redhead, E., Parker, M.O. (2021) Dopaminergic modulation of working memory and cognitive flexibility in a zebrafish model of aging-related cognitive decline. Neurobiology of aging. 102:1-16

Ponzoni, L., Melzi, G., Marabini, L., Martini, A., Petrillo, G., Teh, M.T., Torres-Perez, J.V., Morara, S., Gotti, C., Braida, D., Brennan, C.H., Sala, M. (2021) Conservation of mechanisms regulating emotional-like responses on spontaneous nicotine withdrawal in zebrafish and mammals. Progress in neuro-psychopharmacology & biological psychiatry. 111:110334

van Reij, R.R.I., Salmans, M.M.A., Eijkenboom, I., van den Hoogen, N.J., Joosten, E.A.J., Vanoevelen, J.M. (2021) Dopamine-neurotransmission and nociception in zebrafish: An anti-nociceptive role of dopamine receptor drd2a. European Journal of Pharmacology. 912:174517

Chen, Z., Zhijie, C., Yuting, Z., Shilin, X., Qichun, Z., Jinying, O., Chaohua, L., Jing, L., Zhixian, M. (2020) Antibiotic-Driven Gut Microbiome Disorder Alters the Effects of Sinomenine on Morphine-Dependent Zebrafish. Frontiers in microbiology. 11:946

García-González, J., Brock, A.J., Parker, M.O., Riley, R.J., Joliffe, D., Sudwarts, A., Teh, M.T., Busch-Nentwich, E.M., Stemple, D.L., Martineau, A.R., Kaprio, J., Palviainen, T., Kuan, V., Walton, R.T., Brennan, C.H. (2020) Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour. eLIFE. 9:

Paiva, I.M., de Carvalho, L.M., Di Chiaccio, I.M., de Lima Assis, I., Sánchez, E.N., Garcia, M.B., Ferreira, F.N.A., Cayuela, M.L., Murgas, L.D.S., Godard, A.L.B. (2020) Inhibition of Lrrk2 reduces ethanol preference in a model of acute exposure in zebrafish. Progress in neuro-psychopharmacology & biological psychiatry. 100:109885

Paiva, I.M., Sartori, B.M., Castro, T.F.D., Lunkes, L.C., Virote, B.D.C.R., Murgas, L.D.S., de Souza, R.P., Brunialti-Godard, A.L. (2020) Behavioral plasticity and gene regulation in the brain during an intermittent ethanol exposure in adult zebrafish population. Pharmacology, biochemistry, and behavior. 192:172909

Roche, J., Hergalant, S., Depp, A., Ben Ammar, I., Lafont, A.G., Policar, T., Fontaine, P., Milla, S. (2020) First identification of dopamine receptors in pikeperch, Sander lucioperca, during the pre-ovulatory period. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 36:100747

Safarian, N., Whyte-Fagundes, P., Zoidl, C., Grigull, J., Zoidl, G. (2020) Visuomotor deficiency in panx1a knockout zebrafish is linked to dopaminergic signaling. Scientific Reports. 10:9538

Tu, X., Li, Y.W., Chen, Q.L., Shen, Y.J., Liu, Z.H. (2020) Tributyltin enhanced anxiety of adult male zebrafish through elevating cortisol level and disruption in serotonin, dopamine and gamma-aminobutyric acid neurotransmitter pathways. Ecotoxicology and environmental safety. 203:111014

Wang, X.H., Souders, C.L., Xavier, P., Li, X.Y., Yan, B., Martyniuk, C.J. (2020) The pyrethroid esfenvalerate induces hypoactivity and decreases dopamine transporter expression in embryonic/larval zebrafish (Danio rerio). Chemosphere. 243:125416

Liang, X., Zhao, Y., Liu, W., Li, Z., Souders, C.L., Martyniuk, C.J. (2019) Butylated hydroxytoluene induces hyperactivity and alters dopamine-related gene expression in larval zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 257:113624

Lv, D.J., Li, L.X., Chen, J., Wei, S.Z., Wang, F., Hu, H., Xie, A.M., Liu, C.F. (2019) Sleep Deprivation caused a Memory Defects and Emotional Changes in a Rotenone-based Zebrafish Model of Parkinson's Disease. Behavioural brain research. 372:112031

Souders, C.L., Davis, R.H., Qing, H., Liang, X., Febo, M., Martyniuk, C.J. (2019) The psychoactive cathinone derivative pyrovalerone alters locomotor activity and decreases dopamine receptor expression in zebrafish (Danio rerio). Brain and behavior. 9(11):e01420

Cao, F., Souders, C.L., Li, P., Adamovsky, O., Pang, S., Qiu, L., Martyniuk, C.J. (2018) Developmental toxicity of the fungicide ziram in zebrafish (Danio rerio). Chemosphere. 214:303-313

Cao, F., Souders, C.L., Li, P., Pang, S., Liang, X., Qiu, L., Martyniuk, C.J. (2018) Developmental neurotoxicity of maneb: Notochord defects, mitochondrial dysfunction and hypoactivity in zebrafish (Danio rerio) embryos and larvae. Ecotoxicology and environmental safety. 170:227-237

Opazo, J.C., Zavala, K., Miranda-Rottmann, S., Araya, R. (2018) Evolution of dopamine receptors: phylogenetic evidence suggests a later origin of the DRD_2l and DRD_4rs dopamine receptor gene lineages. PeerJ. 6:e4593

Shontz, E.C., Souders Ii, C.L., Schmidt, J.T., Martyniuk, C.J. (2018) Domperidone up-regulates dopamine receptor expression and stimulates locomotor activity in larval zebrafish (Danio rerio). Genes, brain, and behavior. 17(4):e12460

Thörnqvist, P.O., McCarrick, S., Ericsson, M., Roman, E., Winberg, S. (2018) Bold zebrafish (Danio rerio) express higher levels of delta opioid and dopamine D2 receptors in the brain compared to shy fish. Behavioural brain research. 359:927-934

Wang, X.H., Zheng, S.S., Huang, T., Su, L.M., Zhao, Y.H., Souders, C.L., Martyniuk, C.J. (2018) Fluazinam impairs oxidative phosphorylation and induces hyper/hypo-activity in a dose specific manner in zebrafish larvae. Chemosphere. 210:633-644

Zheng, Y., Yuan, J., Meng, S., Chen, J., Gu, Z. (2018) Testicular transcriptome alterations in zebrafish (Danio rerio) exposure to 17β-estradiol. Chemosphere. 218:14-25

Bertotto, L.B., Richards, J., Gan, J., Volz, D.C., Schlenk, D. (2017) EFFECTS OF BIFENTHRIN EXPOSURE ON THE ESTROGENIC AND DOPAMINERGIC PATHWAYS IN ZEBRAFISH EMBRYOS AND JUVENILES. Environmental toxicology and chemistry. 37(1):236-246

Förster, D., Arnold-Ammer, I., Laurell, E., Barker, A.J., Fernandes, A.M., Finger-Baier, K., Filosa, A., Helmbrecht, T.O., Kölsch, Y., Kühn, E., Robles, E., Slanchev, K., Thiele, T.R., Baier, H., Kubo, F. (2017) Genetic targeting and anatomical registration of neuronal populations in the zebrafish brain with a new set of BAC transgenic tools. Scientific Reports. 7:5230

Liang, X., Souders, C.L., Zhang, J., Martyniuk, C.J. (2017) Tributyltin induces premature hatching and reduces locomotor activity in zebrafish (Danio rerio) embryos/larvae at environmentally relevant levels. Chemosphere. 189:498-506

Puttonen, H.A.J., Sundvik, M., Semenova, S., Shirai, Y., Chen, Y.C., Panula, P. (2017) Knock-out of histamine receptor H3 alters adaptation to sudden darkness and monoamine levels in the zebrafish. Acta physiologica (Oxford, England). 222(3)

Sarty, K.I., Cowie, A., Martyniuk, C.J. (2017) The legacy pesticide dieldrin acts as a teratogen and alters the expression of dopamine transporter and dopamine receptor 2a in zebrafish (Danio rerio) embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 194:37-47

Wang, X.H., Souders, C.L., Zhao, Y.H., Martyniuk, C.J. (2017) Paraquat affects mitochondrial bioenergetics, dopamine system expression, and locomotor activity in zebrafish (Danio rerio). Chemosphere. 191:106-117

Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37

Chen, Y.C., Semenova, S., Rozov, S., Sundvik, M., Bonkowsky, J.L., Panula, P. (2016) A novel developmental role for dopaminergic signaling to specify hypothalamic neurotransmitter identity. The Journal of biological chemistry. 291(42):21880-21892

Ek, F., Malo, M., Åberg Andersson, M., Wedding, C., Kronborg, J., Svensson, P., Waters, S., Petersson, P., Olsson, R. (2016) Behavioral analysis of dopaminergic activation in zebrafish and rats reveals similar phenotypes. ACS Chemical Neuroscience. 7(5):633-46

Parker, M.O., Brock, A.J., Sudwarts, A., Teh, M.T., Combe, F.J., Brennan, C.H. (2015) Developmental role of acetylcholinesterase in impulse control in zebrafish. Frontiers in behavioral neuroscience. 9:271

Toro, C., Trapani, J.G., Pacentine, I., Maeda, R., Sheets, L., Mo, W., Nicolson, T. (2015) Dopamine Modulates the Activity of Sensory Hair Cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(50):16494-16503

Fontaine, R., Affaticati, P., Yamamoto, K., Jolly, C., Bureau, C., Baloche, S., Gonnet, F., Vernier, P., Dufour, S., and Pasqualini, C. (2013) Dopamine Inhibits Reproduction in Female Zebrafish (Danio rerio) via Three Pituitary D2 Receptor Subtypes. Endocrinology. 154(2):807-818

Liu, F., Pogoda, H.M., Pearson, C.A., Ohyama, K., Löhr, H., Hammerschmidt, M., and Placzek, M. (2013) Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis. Development (Cambridge, England). 140(5):1111-1122

Barreto-Valer, K., López-Bellido, R., Macho Sánchez-Simón, F., and Rodríguez, R.E. (2012) Modulation by Cocaine of Dopamine Receptors through miRNA-133b in Zebrafish Embryos. PLoS One. 7(12):e52701

Klee, E.W., Schneider, H., Clark, K.J., Cousin, M.A., Ebbert, J.O., Hooten, W.M., Karpyak, V.M., Warner, D.O., and Ekker, S.C. (2012) Zebrafish: a model for the study of addiction genetics. Human genetics. 131(6):977-1008

Pan, Y., Chaterjee, D., and Gerlai, R. (2012) Strain dependent gene expression and neurochemical levels in the brain of zebrafish: Focus on a few alcohol related targets. Physiology & behavior. 107(5):773-780

Filby, A.L., Paull, G.C., Hickmore, T.F., and Tyler, C.R. (2010) Unravelling the neurophysiological basis of aggression in a fish model. BMC Genomics. 11:498

Auer, R.L., Riaz, S., and Cotter, F.E. (2007) The 13q and 11q B-cell chronic lymphocytic leukaemia-associated regions derive from a common ancestral region in the zebrafish. British journal of haematology. 137(5):443-453

Liu, N.A., Liu, Q., Wawrowsky, K., Yang, Z., Lin, S., and Melmed, S. (2006) Prolactin receptor signaling mediates the osmotic response of embryonic zebrafish lactotrophs. Molecular endocrinology (Baltimore, Md.). 20(4):871-880

Boehmler, W., Obrecht-Pflumio, S., Canfield, V., Thisse, C., Thisse, B., and Levenson, R. (2004) Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 230(3):481-493

Additional Citations (17):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.