PUBLICATION
Developmental role of acetylcholinesterase in impulse control in zebrafish
- Authors
- Parker, M.O., Brock, A.J., Sudwarts, A., Teh, M.T., Combe, F.J., Brennan, C.H.
- ID
- ZDB-PUB-151104-5
- Date
- 2015
- Source
- Frontiers in behavioral neuroscience 9: 271 (Journal)
- Registered Authors
- Brennan, Caroline
- Keywords
- 5-choice serial reaction time, Dopamine D2 receptor, acetylcholinesterase, impulsivity, zebrafish
- MeSH Terms
- none
- PubMed
- 26528153 Full text @ Front. Behav. Neurosci.
Citation
Parker, M.O., Brock, A.J., Sudwarts, A., Teh, M.T., Combe, F.J., Brennan, C.H. (2015) Developmental role of acetylcholinesterase in impulse control in zebrafish. Frontiers in behavioral neuroscience. 9:271.
Abstract
Cellular and molecular processes that mediate individual variability in impulsivity, a key behavioral component of many neuropsychiatric disorders, are poorly understood. Zebrafish heterozygous for a nonsense mutation in ache (ache (sb55/+)) showed lower levels of impulsivity in a 5-choice serial reaction time task (5-CSRTT) than wild type and ache(+∕+). Assessment of expression of cholinergic (nAChR), serotonergic (5-HT), and dopamine (DR) receptor mRNA in both adult and larval (9 dpf) ache (sb55/+) revealed significant downregulation of chrna2, chrna5, and drd2 mRNA in ache (sb55/+) larvae, but no differences in adults. Acute exposure to cholinergic agonist/antagonists had no effect on impulsivity, supporting the hypothesis that behavioral effects observed in adults were due to lasting impact of developmental alterations in cholinergic and dopaminergic signaling. This shows the cross-species role of cholinergic signaling during brain development in impulsivity, and suggests zebrafish may be a useful model for the role of cholinergic pathways as a target for therapeutic advances in addiction medicine.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping