ZFIN

ZFIN ID: ZDB-GENE-020806-2

ZFIN ID: ZDB-GENE-020806-2

CITATIONS (58 total)

Gene Name:	purinergic receptor P2X, ligand-gated ion channel, 4a
Gene Symbol:	p2rx4a

Chen, P.F., Ma, X.F., Sun, L.F., Tian, Y., Fan, Y.Z., Li, P., Xiao, Z., Zhu, M.X., Guo, C.R., Li, C., Yu, Y., Wang, J. (2021) A conserved residue in the P2X4 receptor has a nonconserved function in ATP recognition. The Journal of biological chemistry. 296:100655

Fukui, H., Chow, R.W., Xie, J., Foo, Y.Y., Yap, C.H., Minc, N., Mochizuki, N., Vermot, J. (2021) Bioelectric signaling and the control of cardiac cell identity in response to mechanical forces. Science (New York, N.Y.). 374:351-354

Racigh, V., Pierdominici-Sottile, G., Palma, J. (2021) Ion Selectivity in P2X Receptors: A Comparison between hP2X3 and zfP2X4. The journal of physical chemistry. B. 125(49):13385-13393

Zhang, Z., Wang, Y., Ding, Y., Hattori, M. (2020) Structure-based engineering of anti-GFP nanobody tandems as ultra-high-affinity reagents for purification. Scientific Reports. 10:6239

Ase, A.R., Therrien, É., Séguéla, P. (2019) An Allosteric Inhibitory Site Conserved in the Ectodomain of P2X Receptor Channels. Frontiers in Cellular Neuroscience. 13:121

Kasuya, G., Fujiwara, Y., Tsukamoto, H., Morinaga, S., Ryu, S., Touhara, K., Ishitani, R., Furutani, Y., Hattori, M., Nureki, O. (2017) Structural insights into the nucleotide base specificity of P2X receptors. Scientific Reports. 7:45208

Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37

Minato, Y., Suzuki, S., Hara, T., Kofuku, Y., Kasuya, G., Fujiwara, Y., Igarashi, S., Suzuki, E.I., Nureki, O., Hattori, M., Ueda, T., Shimada, I. (2016) Conductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane region. Proceedings of the National Academy of Sciences of the United States of America. 113(17):4741-6

Smith, L.C., Clark, J.C., Bisesi, J.H., Ferguson, P.L., Sabo-Attwood, T. (2016) Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 19:159-73

Ase, A.R., Honson, N.S., Zaghdane, H., Pfeifer, T.A., Seguela, P. (2015) Identification and Characterization of a Selective Allosteric Antagonist of Human P2X4 Receptor Channels. Molecular pharmacology. 87(4):606-16

Dal Ben, D., Buccioni, M., Lambertucci, C., Marucci, G., Thomas, A., Volpini, R. (2015) Purinergic P2X receptors: Structural models and analysis of ligand-target interaction. European Journal of Medicinal Chemistry. 89C:561-580

Igawa, T., Abe, Y., Tsuda, M., Inoue, K., Ueda, T. (2015) Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding. FEBS letters. 589(6):680-6

Li, G.H. (2015) Geometric rules of channel gating inferred from computational models of the P2X receptor transmembrane domain. Journal of molecular graphics & modelling. 61:107-114

Huang, L.D., Fan, Y.Z., Tian, Y., Yang, Y., Liu, Y., Wang, J., Zhao, W.S., Zhou, W.C., Cheng, X.Y., Cao, P., Lu, X.Y., Yu, Y. (2014) Inherent Dynamics of Head Domain Correlates with ATP-Recognition of P2X4 Receptors: Insights Gained from Molecular Simulations. PLoS One. 9:e97528

Jie, Y., Zhang, L., Xu, H., Gao, C., Ma, W., Li, Z. (2014) Involvement of the left-flipper-to-dorsal-fin interface of the zebrafish P2X4 receptor in ATP binding and structural rearrangement. Neuroscience letters. 582:1-5

Tvrdonova, V., Rokic, M.B., Stojilkovic, S.S., Zemkova, H. (2014) Identification of Functionally Important Residues of the Rat P2X4 Receptor by Alanine Scanning Mutagenesis of the Dorsal Fin and Left Flipper Domains. PLoS One. 9:e112902

Xu, J., Chai, H., Ehinger, K., Egan, T.M., Srinivasan, R., Frick, M., Khakh, B.S. (2014) Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin. The Journal of general physiology. 144(1):81-104

Hausmann, R., Gunther, J., Kless, A., Kuhlmann, D., Kassack, M.U., Bahrenberg, G., Markwardt, F., and Schmalzing, G. (2013) Salt Bridge Switching from Arg290/Glu167 to Arg290/ATP Promotes the Closed-to-open Transition of the P2X2 Receptor. Molecular pharmacology. 83(1):73-84

Heymann, G., Dai, J., Li, M., Silberberg, S.D., Zhou, H.X., and Swartz, K.J. (2013) Inter- and intrasubunit interactions between transmembrane helices in the open state of P2X receptor channels. Proceedings of the National Academy of Sciences of the United States of America. 110(42):E4045-E4054

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Hattori, M., and Gouaux, E. (2012) Molecular mechanism of ATP binding and ion channel activation in P2X receptors. Nature. 485(7397):207-212

Hattori, M., Hibbs, R.E., Gouaux, E. (2012) A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening. Structure (London, England : 1993). 20:129312991293-9

Punthambaker, S., Blum, J.A., and Hume, R.I. (2012) High potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanism. The Journal of biological chemistry. 287(26):22099-22111

Kawate, T., Robertson, J.L., Li, M., Silberberg, S.D., and Swartz, K.J. (2011) Ion access pathway to the transmembrane pore in P2X receptor channels. The Journal of general physiology. 137(6):579-590

Petrenko, N., Khafizov, K., Tvrdonova, V., Skorinkin, A., and Giniatullin, R. (2011) The role of the ectodomain serine 275 in shaping the binding pocket of ATP-gated P2X3 receptor. Biochemistry. 50(39):8427-36

Valente, M., Watterson, S.J., Parker, M.D., Ford, R.C., and Young, M.T. (2011) Expression, purification, electron microscopy, N-glycosylation mutagenesis and molecular modeling of human P2X4 and Dictyostelium discoideum P2XA. Biomembranes. 1808(12):2859-66

Cao, L., Broomhead, H.E., Young, M.T., and North, R.A. (2009) Polar residues in the second transmembrane domain of the rat P2X2 receptor that affect spontaneous gating, unitary conductance, and rectification. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(45):14257-14264

Gonzales, E.B., Kawate, T., and Gouaux, E. (2009) Pore architecture and ion sites in acid-sensing ion channels and P2X receptors. Nature. 460(7255):599-604

Kawate, T., Michel, J.C., Birdsong, W.T., and Gouaux, E. (2009) Crystal structure of the ATP-gated P2X(4) ion channel in the closed state. Nature. 460(7255):592-598

Low, S.E., Kuwada, J.Y., and Hume, R.I. (2008) Amino acid variations resulting in functional and nonfunctional zebrafish P2X(1) and P2X (5.1) receptors. Purinergic signalling. 4(4):383-392

Appelbaum, L., Skariah, G., Mourrain, P., and Mignot, E. (2007) Comparative expression of p2x receptors and ecto-nucleoside triphosphate diphosphohydrolase 3 in hypocretin and sensory neurons in zebrafish. Brain research. 1174(1):66-75

Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433

Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314

Kucenas, S., Li, Z., Cox, J.A., Egan, T.M., and Voigt, M.M. (2003) Molecular characterization of the zebrafish P2X receptor subunit gene family. Neuroscience. 121(4):935-945

Diaz-Hernandez, M., Cox, J.A., Migita, K., Haines, W., Egan, T.M., and Voigt, M.M (2002) Cloning and characterization of two novel zebrafish P2X receptor subunits. Biochemical and Biophysical Research Communications. 295(4):849-853

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (22):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA curators, UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. Manually curated data.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

Thisse, B., Thisse, C. (2004) Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of FPC Database Links. Automated Data Submission.

ZFIN Staff (2003) Computational Sequence to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.