Gene
p2rx4a
- ID
- ZDB-GENE-020806-2
- Name
- purinergic receptor P2X, ligand-gated ion channel, 4a
- Symbol
- p2rx4a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Enables extracellularly ATP-gated monoatomic cation channel activity; identical protein binding activity; and ribonucleotide binding activity. Acts upstream of or within calcium ion transport. Located in membrane. Part of monoatomic ion channel complex. Orthologous to human P2RX4 (purinergic receptor P2X 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55286 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028307Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ATP P2X receptor, conserved site | P2X4 purinoceptor | P2X purinoreceptor | P2X purinoreceptor extracellular domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q98TZ0
|
389 | ||||
|
UniProtKB:A0A8M9PI33
|
308 | ||||
|
UniProtKB:A0A8M3AWS5
|
282 | ||||
|
UniProtKB:Q6NYR1
|
389 | ||||
|
UniProtKB:F8W463
|
389 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
p2rx4a-201
(1)
|
Ensembl | 1,481 nt | ||
| mRNA |
p2rx4a-202
(1)
|
Ensembl | 1,457 nt | ||
| ncRNA |
p2rx4a-003
(1)
|
Ensembl | 648 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-87D8 | ZFIN Curated Data | |
| Encodes | EST | fi03f02 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55286 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77525 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191892 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_153653 (1) | 1330 nt | ||
| Genomic | GenBank:BX530059 (1) | 179045 nt | ||
| Polypeptide | UniProtKB:F8W463 (1) | 389 aa |
- Chen, P.F., Ma, X.F., Sun, L.F., Tian, Y., Fan, Y.Z., Li, P., Xiao, Z., Zhu, M.X., Guo, C.R., Li, C., Yu, Y., Wang, J. (2021) A conserved residue in the P2X4 receptor has a nonconserved function in ATP recognition. The Journal of biological chemistry. 296:100655
- Fukui, H., Chow, R.W., Xie, J., Foo, Y.Y., Yap, C.H., Minc, N., Mochizuki, N., Vermot, J. (2021) Bioelectric signaling and the control of cardiac cell identity in response to mechanical forces. Science (New York, N.Y.). 374:351-354
- Racigh, V., Pierdominici-Sottile, G., Palma, J. (2021) Ion Selectivity in P2X Receptors: A Comparison between hP2X3 and zfP2X4. The journal of physical chemistry. B. 125(49):13385-13393
- Zhang, Z., Wang, Y., Ding, Y., Hattori, M. (2020) Structure-based engineering of anti-GFP nanobody tandems as ultra-high-affinity reagents for purification. Scientific Reports. 10:6239
- Ase, A.R., Therrien, É., Séguéla, P. (2019) An Allosteric Inhibitory Site Conserved in the Ectodomain of P2X Receptor Channels. Frontiers in Cellular Neuroscience. 13:121
- Kasuya, G., Fujiwara, Y., Tsukamoto, H., Morinaga, S., Ryu, S., Touhara, K., Ishitani, R., Furutani, Y., Hattori, M., Nureki, O. (2017) Structural insights into the nucleotide base specificity of P2X receptors. Scientific Reports. 7:45208
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Minato, Y., Suzuki, S., Hara, T., Kofuku, Y., Kasuya, G., Fujiwara, Y., Igarashi, S., Suzuki, E.I., Nureki, O., Hattori, M., Ueda, T., Shimada, I. (2016) Conductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane region. Proceedings of the National Academy of Sciences of the United States of America. 113(17):4741-6
- Smith, L.C., Clark, J.C., Bisesi, J.H., Ferguson, P.L., Sabo-Attwood, T. (2016) Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 19:159-73
- Ase, A.R., Honson, N.S., Zaghdane, H., Pfeifer, T.A., Seguela, P. (2015) Identification and Characterization of a Selective Allosteric Antagonist of Human P2X4 Receptor Channels. Molecular pharmacology. 87(4):606-16
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