ZFIN

ZFIN ID: ZDB-GENE-020604-1

ZFIN ID: ZDB-GENE-020604-1

CITATIONS (86 total)

Gene Name:	myosin, heavy polypeptide 2, fast muscle specific
Gene Symbol:	myhz2

Ikeda, D., Fujita, S., Toda, K., Yaginuma, Y., Kan-No, N., Watabe, S. (2023) Cold-induced muscle atrophy in zebrafish: Insights from swimming activity and gene expression analysis. Biochemistry and biophysics reports. 36:101570101570

Seda, M., Crespo, B., Corcelli, M., Osborn, D.P., Jenkins, D. (2023) A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis. Scientific Reports. 13:67836783

Liu, G., Ito, T., Kijima, Y., Yoshitake, K., Asakawa, S., Watabe, S., Kinoshita, S. (2022) Zebrafish Danio rerio myotomal muscle structure and growth from a spatial transcriptomics perspective. Genomics. 114(5):110477

Lukowicz-Bedford, R.M., Farnsworth, D.R., Miller, A.C. (2022) Connexinplexity: The spatial and temporal expression of connexin genes during vertebrate organogenesis. G3 (Bethesda). 12(5):

Ghilardi, A., Diana, A., Bacchetta, R., Santo, N., Ascagni, M., Prosperi, L., Del Giacco, L. (2021) Inner Ear and Muscle Developmental Defects in Smpx-Deficient Zebrafish Embryos. International Journal of Molecular Sciences. 22(12):

Hsu, P.J., Wang, H.D., Tseng, Y.C., Pan, S.W., Sampurna, B.P., Jong, Y.J., Yuh, C.H. (2021) L-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish. Journal of Biomedical Science. 28:8

Li, S., Wen, H., Du, S. (2020) Defective sarcomere organization and reduced larval locomotion and fish survival in slow muscle heavy chain 1 (smyhc1) mutants. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:1378-1397

Cai, M., Han, L., Liu, L., He, F., Chu, W., Zhang, J., Tian, Z., Du, S. (2019) Defective sarcomere assembly in smyd1a and smyd1b zebrafish mutants. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(5):6209-6225

Gao, T., Li, J., Li, N., Gao, Y., Yu, L., Zhuang, S., Zhao, Y., Dong, X. (2019) lncrps25 play an essential role in motor neuron development through controlling the expression of olig2 in zebrafish. Journal of Cellular Physiology. 235(4):3485-3496

Healy, T.M., Schulte, P.M. (2019) Patterns of alternative splicing in response to cold acclimation in fish. The Journal of experimental biology. 222(Pt 5):

Garcia de la Serrana, D., Wreggelsworth, K., Johnston, I.A. (2018) Duplication of a Single myhz1.1 Gene Facilitated the Ability of Goldfish (Carassius auratus) to Alter Fast Muscle Contractile Properties With Seasonal Temperature Change. Frontiers in Physiology. 9:1724

Kendall, G.C., Watson, S., Xu, L., LaVigne, C.A., Murchison, W., Rakheja, D., Skapek, S.X., Tirode, F., Delattre, O., Amatruda, J.F. (2018) PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis.. eLIFE. 7

Kwon, O.K., Kim, S.J., Lee, S. (2018) First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos. Scientific Reports. 8:3652

Shi, J., Cai, M., Si, Y., Zhang, J., Du, S. (2018) Knockout of myomaker results in defective myoblast fusion, reduced muscle growth and increased adipocyte infiltration in zebrafish skeletal muscle. Human molecular genetics. 27(20):3542-3554

Si, Y., Wen, H., Du, S. (2018) Genetic Mutations in jamb, jamc, and myomaker Revealed Different Roles on Myoblast Fusion and Muscle Growth. Marine biotechnology (New York, N.Y.). 21(1):111-123

Xu, Q.H., Guan, P., Zhang, T., Lu, C., Li, G., Liu, J.X. (2018) Silver nanoparticles impair zebrafish skeletal and cardiac myofibrillogenesis and sarcomere formation. Aquatic toxicology (Amsterdam, Netherlands). 200:102-113

Zhang, L., Yang, Y., Li, B., Scott, I.C., Lou, X. (2018) The DEAD box RNA helicase Ddx39ab is essential for myocyte and lens development in zebrafish. Development (Cambridge, England). 145(8)

Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613

Cortelazzo, A., Pietri, T., De Felice, C., Leoncini, S., Guerranti, R., Signorini, C., Timperio, A.M., Zolla, L., Ciccoli, L., Hayek, J. (2017) Proteomic analysis of the Rett syndrome experimental model mecp2^Q63X mutant zebrafish.. Journal of proteomics. 154:128-133

Henke, K., Daane, J.M., Hawkins, M.B., Dooley, C.M., Busch-Nentwich, E.M., Stemple, D.L., Harris, M.P. (2017) Genetic Screen for Postembryonic Development in the Zebrafish (Danio rerio): Dominant Mutations Affecting Adult Form.. Genetics. 207(2):609-623

Lu, C., Wu, J., Xiong, S., Zhang, X., Zhang, J., Mei, J. (2017) MicroRNA-203a regulates fast muscle differentiation by targeting dmrt2a in zebrafish embryos. Gene. 625:49-54

Shi, J., Bi, P., Pei, J., Li, H., Grishin, N.V., Bassel-Duby, R., Chen, E.H., Olson, E.N. (2017) Requirement of the fusogenic micropeptide myomixer for muscle formation in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(45):11950-11955

Wang, L., Wang, X., Wang, L., Yousaf, M., Li, J., Zuo, M., Yang, Z., Gou, D., Bao, B., Li, L., Xiang, N., Jia, H., Xu, C., Chen, Q., Wang, Q.K. (2017) Identification of a new adtrp1-tfpi regulatory axis for the specification of primitive myelopoiesis and definitive hematopoiesis.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(1):183-194

Asaduzzaman, M., Shakur Ahammad, A.K., Asakawa, S., Kinoshita, S., Watabe, S. (2016) 5′-flanking sequences of zebrafish fast myosin heavy chain genes regulate unique expression in the anterior, medial subsection and posterior tail somites of the skeletal muscle. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 191:1-12

Burghardt, T.P., Ajtai, K., Sun, X., Takubo, N., Wang, Y. (2016) In vivo myosin step-size from zebrafish skeletal muscle. Open Biology. 6(5)

Qiu, J., Fan, X., Wang, Y., Jin, H., Song, Y., Han, Y., Huang, S., Meng, Y., Tang, F., Meng, A. (2016) Embryonic hematopoiesis in vertebrate somites gives rise to definitive hematopoietic stem cells. Journal of molecular cell biology. 8(4):288-301

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Fiaz, A. W., Léon-Kloosterziel, K. M., van Leeuwen, J. L., Kranenbarg, S. (2014) Exploring the effect of exercise on the transcriptome of zebrafish larvae (Danio rerio). Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 30(4):728-739

Gao, J., Li, J., Li, B.J., Yagil, E., Zhang, J., and Du, S.J. (2014) Expression and functional characterization of Smyd1a in myofibril organization of skeletal muscles. PLoS One. 9(1):e86808

Nord, H., Burguiere, A.C., Muck, J., Nord, C., Ahlgren, U., and von Hofsten, J. (2014) Differential regulation of myosin heavy chains defines new muscle domains in zebrafish. Molecular biology of the cell. 25(8):1384-95

Zhang, P., Yao, Q., Lu, L., Li, Y., Chen, P.J., Duan, C. (2014) Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Reports. 6:1110-21

Bohnsack, B.L., and Kahana, A. (2013) Thyroid hormone and retinoic acid interact to regulate zebrafish craniofacial neural crest development. Developmental Biology. 373(2):300-309

Chen, K., Cole, R.B., and Rees, B.B. (2013) Hypoxia-induced changes in the zebrafish (Danio rerio) skeletal muscle proteome. Journal of proteomics. 78:477-485

Devakanmalai, G.S., Zumrut, H.E., and Ozbudak, E.M. (2013) Cited3 activates Mef2c to control muscle cell differentiation and survival. Biology Open. 2(5):505-514

Doganli, C., Beck, H.C., Ribera, A.B., Oxvig, C., and Lykke-Hartmann, K. (2013) α3Na+/K+-ATPase Deficiency Causes Brain Ventricle Dilation and Abrupt Embryonic Motility in Zebrafish. The Journal of biological chemistry. 288(13):8862-8874

Ikeda, D., Ono, Y., Hirano, S., Kan-No, N., and Watabe, S. (2013) Lampreys have a single gene cluster for the fast skeletal Myosin heavy chain gene family. PLoS One. 8(12):e85500

Li, H., Zhong, Y., Wang, Z., Gao, J., Xu, J., Chu, W., Zhang, J., Fang, S., and Du, S.J. (2013) Smyd1b is required for skeletal and cardiac muscle function in zebrafish. Molecular biology of the cell. 24(22):3511-21

Li, Y.H., Chen, H.Y., Li, Y.W., Wu, S.Y., Wangta, L., Lin, G.H., Hu, S.Y., Chang, Z.K., Gong, H.Y., Liao, C.H., Chiang, K.Y., Huang, C.W., and Wu, J.L. (2013) Progranulin regulates zebrafish muscle growth and regeneration through maintaining the pool of myogenic progenitor cells. Scientific Reports. 3:1176

Little, A.G., and Seebacher, F. (2013) Thyroid hormone regulates muscle function during cold acclimation in zebrafish (Danio rerio). The Journal of experimental biology. 216(18):3514-3521

Doganli, C., Kjaer-Sorensen, K., Knoeckel, C., Beck, H.C., Nyengaard, J.R., Honoré, B., Nissen, P., Ribera, A., Oxvig, C., and Lykke-Hartmann, K. (2012) The alpha2Na+/K+-ATPase is critical for skeletal and heart muscle function in zebrafish. Journal of Cell Science. 125(24):6166-6175

English, M.A., Lei, L., Blake, T., Wincovitch, S.M., Sood, R., Azuma, M., Hickstein, D., and Paul Liu, P. (2012) Incomplete splicing, cell division defects, and hematopoietic blockage in dhx8 mutant zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 241(5):879-889

Gündel, U., Kalkhof, S., Zitzkat, D., von Bergen, M., Altenburger, R., and Küster, E. (2012) Concentration-response concept in ecotoxicoproteomics: Effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome. Ecotoxicology and environmental safety. 76(2):11-22

Nesan, D., Kamkar, M., Burrows, J., Scott, I.C., Marsden, M., Vijayan, M.M. (2012) Glucocorticoid Receptor Signaling Is Essential for Mesoderm Formation and Muscle Development in Zebrafish. Endocrinology. 153(3):1288-1300

Bohnsack, B.L., Gallina, D., Thompson, H., Kasprick, D.S., Lucarelli, M.J., Dootz, G., Nelson, C., McGonnell, I.M., and Kahana, A. (2011) Development of Extraocular Muscles Require Early Signals From Periocular Neural Crest and the Developing Eye. Archives of ophthalmology (Chicago, Ill. : 1960). 129(8):1030-1041

Cambier, S., Gonzalez, P., Durrieu, G., Maury-Brachet, R., Boudou, A., and Bourdineaud, J.P. (2010) Serial analysis of gene expression in the skeletal muscles of zebrafish fed with a methylmercury-contaminated diet. Environmental science & technology. 44(1):469-475

Palstra, A.P., Tudorache, C., Rovira, M., Brittijn, S.A., Burgerhout, E., van den Thillart, G.E., Spaink, H.P., and Planas, J.V. (2010) Establishing zebrafish as a novel exercise model: swimming economy, swimming-enhanced growth and muscle growth marker gene expression. PLoS One. 5(12):e14483

Holterhoff, C.K., Saunders, R.H., Brito, E.E., and Wagner, D.S. (2009) Sequence and expression of the zebrafish alpha-actinin gene family reveals conservation and diversification among vertebrates. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(11):2936-2947

Johnston, I.A., Lee, H.T., Macqueen, D.J., Paranthaman, K., Kawashima, C., Anwar, A., Kinghorn, J.R., and Dalmay, T. (2009) Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes. The Journal of experimental biology. 212(Pt 12):1781-1793

Li, H., Randall, W.R., and Du, S.J. (2009) skNAC (skeletal Naca), a muscle-specific isoform of Naca (nascent polypeptide-associated complex alpha), is required for myofibril organization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(6):1988-2000

Ochi, H., and Westerfield, M. (2009) Lbx2 regulates formation of myofibrils. BMC Developmental Biology. 9:13

Tee, J.M., van Rooijen, C., Boonen, R., and Zivkovic, D. (2009) Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. PLoS One. 4(6):e5880

Du, S.J., Li, H., Bian, Y., and Zhong, Y. (2008) Heat-shock protein 90alpha1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos. Proceedings of the National Academy of Sciences of the United States of America. 105(2):554-559

Sittaramane, V., and Chandrasekhar, A. (2008) Expression of unconventional myosin genes during neuronal development in zebrafish. Gene expression patterns : GEP. 8(3):161-170

Deniziak, M., Thisse, C., Rederstorff, M., Hindelang, C., Thisse, B., and Lescure, A. (2007) Loss of selenoprotein N function causes disruption of muscle architecture in the zebrafish embryo. Experimental cell research. 313(1):156-167

Ikeda, D., Ono, Y., Snell, P., Edwards, Y.J., Elgar, G., and Watabe, S. (2007) Divergent evolution of the myosin heavy chain gene family in fish and tetrapods: evidence from comparative genomic analysis. Physiological Genomics. 32(1):1-15

McClelland, G.B., Craig, P.M., Dhekney, K., and Dipardo, S. (2006) Temperature- and exercise-induced gene expression and metabolic enzyme changes in skeletal muscle of adult zebrafish (Danio rerio). The Journal of physiology. 577(2):739-751

van der Meulen, T., Schipper, H., van den Boogaart, J.G., Huising, M.O., Kranenbarg, S., and van Leeuwen, J.L. (2006) Endurance exercise differentially stimulates heart and axial muscle development in zebrafish (Danio rerio). American journal of physiology. Regulatory, integrative and comparative physiology. 291(4):1040-1048

Xu, J., Srinivas, B.P., Tay, S.Y., Mak, A., Yu, X., Lee, S.G., Yang, H., Govindarajan, K.R., Leong, B., Bourque, G., Mathavan, S., and Roy, S. (2006) Genome-wide Expression Profiling in the Zebrafish Embryo Identifies Target Genes Regulated by Hedgehog Signaling During Vertebrate Development. Genetics. 174(2):735-752

Bryson-Richardson, R.J., Daggett, D.F., Cortes, F., Neyt, C., Keenan, D.G., and Currie, P.D. (2005) Myosin heavy chain expression in zebrafish and slow muscle composition. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(3):1018-1022

Groves, J.A., Hammond, C.L., and Hughes, S.M. (2005) Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish. Development (Cambridge, England). 132(19):4211-4222

Leung, Y.F., and Dowling, J.E. (2005) Gene Expression Profiling of Zebrafish Embryonic Retina. Zebrafish. 2(4):269-283

van der Meulen, T., Schipper, H., van Leeuwen, J.L., and Kranenbarg, S. (2005) Effects of decreased muscle activity on developing axial musculature in nicb107 mutant zebrafish (Danio rerio). The Journal of experimental biology. 208(19):3675-3687

Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314

Peng, M.-Y., Wen, H.-J., Shih, L.-J., Kuo, C.-M., and Hwang, S.-P.L. (2002) Myosin heavy chain expression in cranial, pectoral fin, and tail muscle regions of zebrafish embryos. Molecular reproduction and development. 63(4):422-429

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (21):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of EMBL records. Automated Data Submission.

Thisse, B., Pflumio, S., Fürthauer, M., Loppin, B., Heyer, V., Degrave, A., Woehl, R., Lux, A., Steffan, T., Charbonnier, X.Q. and Thisse, C. (2001) Expression of the zebrafish genome during embryogenesis (NIH R01 RR15402). ZFIN Direct Data Submission.